Derek Black grew up at the epicenter of white nationalism. His father founded Stormfront, the largest racist community on the Internet. His godfather, David Duke, was a KKK Grand Wizard. By the time Derek turned 19, he had become an elected politician with his own daily radio show - already regarded as the "the leading light" of the burgeoning white nationalist movement. "We can infiltrate," Derek once told a crowd of white nationalists. "We can take the country back." Then he went to college.

When Michael Pollan set out to research how LSD and psilocybin (the active ingredient in magic mushrooms) are being used to provide relief to people suffering from difficult-to-treat conditions such as depression, addiction, and anxiety, he did not intend to write what is undoubtedly his most personal book. But upon discovering how these remarkable substances are improving the lives not only of the mentally ill but also of healthy people coming to grips with the challenges of everyday life, he decided to explore the landscape of the mind in the first person as well as the third.

In this extraordinary work, Beth Macy takes us into the epicenter of a national drama that has unfolded over two decades. From the labs and marketing departments of big pharma to local doctor's offices; wealthy suburbs to distressed small communities in Central Appalachia; from distant cities to once-idyllic farm towns; the spread of opioid addiction follows a tortuous trajectory that illustrates how this crisis has persisted for so long and become so firmly entrenched.