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Summary of Jennifer A. Doudna & Samuel H. Sternberg’s A Crack in Creation
- Narrado por: Chad Louwerse
- Duración: 26 m
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Resumen del Editor
No time to read? Get the main key insights from this summary of Jennifer A. Doudna and Samuel H. Sternberg’s A Crack in Creation in just a short listen.
A few key insights from Chapter 1:
1. In 1983, biologist Jack Szostak discovered a repair mechanism for breaks in the double strand of DNA.
2. The famous structure of DNA is the double helix, which consists of two strands. In the repair procedure, it is broken by enzymes before a corrected copy of DNA is inserted, which facilitates the healthy copy’s incorporation.
3. By inducing a local double-strand break in the DNA, the genome can be corrected. When the break is introduced, the cell attempts to repair the damage, finding the synthetic gene ready at hand to replace the defective one that was broken.
4. With this discovery, a new challenge arose. Scientists had to find the right enzyme that would break the genome at the right site, singling out the right DNA sequence out of billions of similar sequences.
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Historia
p53: The Gene That Cracked the Cancer Code reveals the tale of the search for this gene, as well as the excitement of the hunt for new cures - the hype, the lost opportunities, the blind alleys, and the thrilling breakthroughs. As the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms starts to take off at last, p53 is still at the forefront of the game. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.
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Excellent story! Unfortunate narration at start
- De Adriana en 12-25-14
De: Sue Armstrong
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The Gene
- An Intimate History
- De: Siddhartha Mukherjee
- Narrado por: Dennis Boutsikaris
- Duración: 19 h y 22 m
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The extraordinary Siddhartha Mukherjee has written a biography of the gene as deft, brilliant, and illuminating as his extraordinarily successful biography of cancer. Weaving science, social history, and personal narrative to tell us the story of one of the most important conceptual breakthroughs of modern times, Mukherjee animates the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.
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It's a Wonderful Book
- De JKC en 06-02-16
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The Language of Life
- DNA and the Revolution in Personalized Medicine
- De: Francis S. Collins
- Narrado por: Greg Itzin
- Duración: 10 h y 45 m
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A scientific and medical revolution has crept up on us, based on study after study, from hundreds of laboratories around the world. It is no longer just a theoretical shift: every one of us will be touched by it, and many of us already have been. The meaning of disease, our understanding of the human body, and crucial decisions about what we all need to know and what choices we make about our health are at stake. Welcome to the new world of personalized medicine.
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The future of medicine
- De Ronald E en 04-12-10
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Life Unfolding
- How the Human Body Creates Itself
- De: Jamie A. Davies
- Narrado por: Napoleon Ryan
- Duración: 9 h y 56 m
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Where did I come from? Why do I have two arms but just one head? How is my left leg the same size as my right one? Why are the fingerprints of identical twins not identical? How did my brain learn to learn? Why must I die? Questions like these remain biology's deepest and most ancient challenges. They force us to confront a fundamental biological problem: How can something as large and complex as a human body organize itself from the simplicity of a fertilized egg?
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Fascinating Biology ; Distracting Narration
- De Tim en 03-01-15
De: Jamie A. Davies
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Editing Humanity
- The CRISPR Revolution and the New Era of Genome Editing
- De: Kevin Davies
- Narrado por: Kevin Davies
- Duración: 16 h y 17 m
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Engrossing and captivating, Editing Humanity takes listeners inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to edit the DNA of any organism down to the individual building blocks of the genetic code. Davies introduces listeners to arguably the most profound scientific breakthrough of our time. He tracks the scientists on the front lines of its research to the patients whose powerful stories bring the narrative movingly to human scale.
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Excellent content, solid execution
- De Samuel Finlayson en 01-25-21
De: Kevin Davies
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Rigor Mortis
- How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions
- De: Richard Harris
- Narrado por: Joe Delafield
- Duración: 5 h y 56 m
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American taxpayers spend $30 billion annually funding biomedical research, but over half of these studies can't be replicated due to poor experimental design, improper methods, and sloppy statistics. Bad science doesn't just hold back medical progress, it can sign the equivalent of a death sentence for terminal patients. In Rigor Mortis, Richard Harris explores these urgent issues with vivid anecdotes, personal stories, and interviews with the top biomedical researchers. We need to fix our dysfunctional biomedical system - before it's too late.
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Eye opening introduction to biomedical R&D
- De Amazon Customer en 09-18-18
De: Richard Harris
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Human Errors
- A Panorama of Our Glitches, from Pointless Bones to Broken Genes
- De: Nathan H. Lents
- Narrado por: L.J. Ganser
- Duración: 7 h y 54 m
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We humans like to think of ourselves as highly evolved creatures. But if we are supposedly evolution's greatest creation, why do we have such bad knees? Why do we catch head colds so often - 200 times more often than a dog does? How come our wrists have so many useless bones? And are we really supposed to swallow and breathe through the same narrow tube? Surely there's been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last.
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From Pointless Bones to Broken Genes to...Aliens?
- De Katy.LED en 12-04-18
De: Nathan H. Lents
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Know This
- Today's Most Interesting and Important Scientific Ideas, Discoveries, and Developments
- De: John Brockman
- Narrado por: Gabra Zackman, Dan John Miller
- Duración: 14 h y 39 m
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Scientific developments radically alter our understanding of the world. Whether it's technology, climate change, health research, or the latest revelations of neuroscience, physics, or psychology, science has, as Edge editor John Brockman says, "become a big story, if not the big story". In that spirit this new addition to Edge.org's fascinating series asks a powerful and provocative question: What do you consider the most interesting and important recent scientific news?
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Pete and Repeat and Re-repeat
- De Daniel L en 02-25-18
De: John Brockman
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How to Clone a Mammoth
- The Science of De-Extinction
- De: Beth Shapiro
- Narrado por: Coleen Marlo
- Duración: 7 h y 13 m
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Could extinct species, like mammoths and passenger pigeons, be brought back to life? The science says yes. In How to Clone a Mammoth, Beth Shapiro, evolutionary biologist and pioneer in "ancient DNA" research, walks listeners through the astonishing and controversial process of de-extinction.
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Very Readable Take on a Complex Subject
- De John en 04-26-15
De: Beth Shapiro
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Herding Hemingway's Cats
- Understanding How Our Genes Work
- De: Kat Arney
- Narrado por: Kat Arney
- Duración: 8 h y 39 m
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The language of genes has become common parlance. We know they make your eyes blue, your hair curly or your nose straight. The media tells us that our genes control the risk of cancer, heart disease, alcoholism or Alzheimer's. The cost of DNA sequencing has plummeted from billions of pounds to a few hundred, and gene-based advances in medicine hold huge promise. So we've all heard of genes, but how do they actually work?
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A non-scientists misguided interpretation
- De AraSevera en 05-15-16
De: Kat Arney
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Arrival of the Fittest
- Solving Evolution's Greatest Puzzle
- De: Andreas Wagner
- Narrado por: Sean Pratt
- Duración: 8 h y 29 m
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In Arrival of the Fittest, renowned evolutionary biologist Andreas Wagner draws on over 15 years of research to present the missing piece in Darwin's theory. Using experimental and computational technologies that were heretofore unimagined, he has found that adaptations are not just driven by chance, but by a set of laws that allow nature to discover new molecules and mechanisms in a fraction of the time that random variation would take.
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Robustness makes for an interesting life and book
- De Gary en 11-29-14
De: Andreas Wagner
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How to Build a Dinosaur
- Extinction Doesn't Have to Be Forever
- De: Jack Horner, James Gorman
- Narrado por: Patrick Lawlor
- Duración: 6 h y 36 m
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In movies, in novels, in comic strips, and on television, we've all seen dinosaurs - or at least somebody's educated guess of what they would look like. But what if it were possible to build, or grow, a real dinosaur without finding ancient DNA? Jack Horner, the scientist who advised Steven Spielberg on the blockbuster film Jurassic Park and a pioneer in bringing paleontology into the 21st century, teams up with the editor of the New York Times's Science Times section to reveal exactly what's in store.
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Good book but misplaced title
- De Robert en 06-19-15
De: Jack Horner, y otros