• #3 – David Andow – Ecological perspectives on the history of genetic engineering

  • Feb 7 2024
  • Duración: 1 h
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#3 – David Andow – Ecological perspectives on the history of genetic engineering Por arte de portada

#3 – David Andow – Ecological perspectives on the history of genetic engineering

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  • Ecological and evolutionary perspectives on genetic engineering David Andow, PhD,  Professor and Department Head, Applied Ecology, NC State University | Profile | @NCStateAEC Ecological and evolutionary perspectives have greatly influenced the development of genetic engineering as exemplified by significant events from history. Download seminar poster [icon name="download" style="solid" class="" unprefixed_class=""] Abstract Ecological and evolutionary perspectives have greatly influenced the development of genetic engineering throughout its relatively recent history. I will focus my discussion on key events during the 1980s, 1990s, and 2000s, many of which reverberate today. By 1980, it was clear that commercial applications of genetic engineering would be released into the environment, but it was not clear what organisms would be released. Generic environmental safety arguments flourished, but ecological and evolutionary critiques torpedoed these, and a careful assessment of likely genetically modified organisms (GMOs) prevailed. These resulted in the case-by-case approach to the risks of GMOs that persists today. In the US, it is enshrined in the 1986 Coordinated Framework. At that time, the focus was on GM microbes, such as ice-minus bacteria and the endophytic bacterium, Clavibacter xyli. Rapid developments in plant transformation, especially maize, completely upended the industry, and in the 1990s, ecological risk assessment shifted accordingly. The exponential increase in the number of releases of GM plants stressed the case-by-case approach, and it was necessary for ecological considerations to address the question of what constitutes a novel case that would require more oversight versus a case similar to one already evaluated. This was also an important contributor to the reopening of non-target evaluations and provided an avenue to implement resistance management in a regulatory context. The 2000s opened with a bang with the Losey, Rayor and Carter 1999 and Quist and Chapela 2001 articles in Nature, which exposed the serious gaps in the ecological risks assessment methods used throughout the world. These gaps present challenges that have yet to be fully resolved today. Related links: Regal, P. J. (1986). Models of genetically engineered organisms and their ecological impact. In Ecology of biological invasions of North America and Hawaii (pp. 111-129). New York, NY: Springer New York.Environmental Management, 1986, 10(4), entire issueKrimsky, S., Andow, D.A., Doyle, J., Mellon, M., and C. Nader. 1987. Beyond the technical problems of intentional release. In J.W. Gillett (ed.), Prospects for Physical and Biological Containment of Genetically Engineered Organisms. Ecosystems Research Center, Cornell University, ERC-114, pp. 67-74.Andow, D.A., S.A. Levin, and M.A. Harwell. 1987. Evaluating environmental risks from biotechnology: Contributions of ecology. In J.R. Fowle III, (ed.), Application of Biotechnology: Environmental and Policy Issues (Westview: Boulder, CO), pp. 125-144.Alstad, D.N. and D.A. Andow. 1995. Managing the evolution of insect resistance to transgenic plants. Science 268: 1894-1896.Andow, D.A. and D.N. Alstad. 1998. The F2 screen for rare resistance alleles. Journal of Economic Entomology, 91: 572-578.Losey, J. E., Rayor, L. S., & Carter, M. E. (1999). Transgenic pollen harms monarch larvae. Nature, 399(6733), 214-214.Quist, D., & Chapela, I. H. (2001). Transgenic DNA introgressed into traditional maize landraces in Oaxaca, Mexico. Nature, 414(6863), 541-543. Andow, D.A. and A.R. Ives. 2002. Monitoring and adaptive resistance management. Ecological Applications 12: 1378–1390. Ives, A.R. and D.A. Andow. 2002. Evolution of resistance to Bt crops: Directional selection in structured environments. Ecology Letters 5:792-801. Haygood, R., A.R. Ives, and D.A. Andow. 2003. Consequences of recurrent gene flow from crops to wild relatives. Proceedings of the Royal Society of London, Series B, 270: 1879-1886. Haygood, R., A. R. Ives and D. A. Andow. 2004. Population genetics of transgene containment. Ecology Letters 7: 213-220.Hilbeck, A. and D.A. Andow (eds). 2004. Environmental Risk Assessment of Transgenic Organisms: A Case Study of Bt Maize in Kenya. CABI: Wallingford, UK. xvii + 281 pp.Andow, D. A. (ed.) 2004. A growing concern: Protecting the food supply in an era of pharmaceutical and industrial crops. Union of Concerned Scientists, Boston, Massachusetts. vi + 125 pp.Hilbeck, A., D.A. Andow and E.M.G. Fontes (eds.). 2006. Environmental Risk Assessment of Genetically Modified Organisms: Methodologies for Assessing Bt Cotton in Brazil. CAB International, Wallingford, UK, xx + 373 pp.Andow, D.A and C. Zwahlen. 2006. Assessing environmental risks of transgenic plants. Ecology Letters 9: 196-214.Andow, D.A., A. Hilbeck and Nguyễn Văn Tuất (eds). 2008. Environmental Risk Assessment of Genetically Modified Organisms: Challenges and Opportunities with Bt Cotton in Viet Nam. CABI ...
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