Dr. Catarina Henriques is a Wellcome Trust/Royal Society Sir Henry Dale Fellow at The University of Sheffield. Her journey into a research career was ignited by a TV documentary on telomeres she watched as a teenager, which fueled her enduring interest in the biology of aging. Transitioning from Portugal to the UK to pursue her research ambitions involved numerous daring conversations.

Not many people can claim they visited embassies to figure out where to study at university, but Catarina did. Before the internet made information readily available, exploring educational opportunities required courage and perseverance. With the support of the British Council, Catarina discovered various Genetics degrees offered across UK universities.

As an undergraduate, Catarina was on a promising path, with a degree in genetics, ample laboratory experience, and strong recommendations. However, personal circumstances required her to return to Portugal to support her family. This detour didn't deter her from her goals.

Determined to work on telomeres, Catarina reached out to anyone involved in related research, leading her to a cancer research group. She maintained connections with a Principal Investigator (PI) at The University of Glasgow, collaboratively developing a PhD project that bridged her interests and academic relationships. Although her PhD project wasn't directly on telomeres, she kept her eye on developments in that area.

After completing her PhD, Catarina stayed in Portugal, joining a new research group transitioning from yeast to zebrafish as a model organism. This period was instrumental in building her confidence to develop her own research team.

She didn't wait for her fellowship to end to explore future opportunities. Instead, she networked and visited research groups to identify potential hosts for a fellowship. Despite an initial unsuccessful fellowship application, her groundbreaking research showing that zebrafish age similarly to humans caught the attention of The University of Sheffield.

A group at The University of Sheffield was at the time looking to recruit a senior academic for zebrafish research; they contacted her PI who put her in touch with the Sheffield team. She was then recruited via some MRC funding that the department held.

The timing worked in her favour as the institution at the time was running a round of internally funded fellowship recruitments which she was encouraged to apply for and was successful in gaining. This was an exciting period, as Catarina really felt that people were interested in her work and were prepared to help her, but also she was surrounded by many other researchers with expertise in zebrafish. Her momentum in building her research niche could be fuelled by colleagues in her department.

Listening to our conversation will prompt your thinking:

• Do you know what brings you energy in your research life?
• What would be the risk in focusing on key research activities instead of scattering yourself and feeling overwhelmed?
• How do you handle conversations about research ownership?

Some reflections to ponder on the transition to being a Principal Investigator

Embracing Uncertainty and Authenticity

Even with a fellowship, there is a long journey to feeling secure in research careers. Learning to live with this level of uncertainty is a challenge.

Research fellows in their attempt to secure more permanent positions will contribute to their departments in many ways from admin roles to teaching. Excelling on all front is challenging. Knowing whether we have done enough is difficult to assess.

For Catarina, like many early career academics, there is a risk of throwing yourself all over the place in your academic activities because you may feel th