Can the Arizona Cardinals seize the moment against the San Francisco 49ers, who are grappling with significant injuries? With Christian McCaffrey out, the Cardinals have a prime opportunity to make their mark.

Kyler Murray's mobility is crucial in this matchup, as his ability to extend plays could open up the field for Marvin Harrison Jr. The spotlight is on rookie Paris Johnson Jr. as he faces off against Nick Bosa, one of the NFL's elite pass rushers. The Cardinals' strategy centers on controlling the clock, aiming to keep the 49ers' potent offense off the field. Even with McCaffrey sidelined, the 49ers have found success in the run game with Jordan Mason stepping up.

Brock Purdy's impressive performances have been a talking point, but questions linger about whether he can maintain this level of play. The NFC West is known for its unpredictable and tightly contested games, adding an extra layer of intrigue to this matchup. The betting line favors the 49ers by 7 points, but the Cardinals are poised to challenge that spread if they execute their game plan effectively.

The bottom line is: can Kyler Murray be special and can the Arizona Cardinals defense hold up against the powerhouse San Francisco 49ers offense? Brian Peacock of Locked On 49ers joins the show for a Week 5 Crossover Thursday. Let's discuss.

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