Dr. Rochelle Hines, an NIH-funded principal investigator at UNLV, discusses her journey into neuroscience, focusing on neurotransmitter systems and their roles in brain disorders. She highlights the importance of GABA, the major inhibitory neurotransmitter, in brain development and its role in disorders like schizophrenia. Hines also explores the interplay between serotonin and GABA, particularly in the context of psychedelics and their therapeutic potential. She emphasizes the need for modulatory therapies over binary on/off approaches, citing her work with synthetic cannabidiol enantiomers and the founding of Tesla Therapeutics. Hines stresses the importance of personalized medicine and the need for better biomarkers in mental health treatments.

The Chemical Collective discusses Ibogaine, a psychoactive and therapeutic substance derived from the Tabernanthe Iboga plant, primarily used in Central Africa for spiritual and healing purposes. Ibogaine's effects include reducing addiction cravings and withdrawal symptoms, potentially due to its interaction with serotonin, NMDA, dopamine, and opioid receptors. It's typically administered in a controlled clinical setting, often as Ibogaine hydrochloride, to ensure safety. Traditional Bwiti rituals involve consuming the root bark, which can lead to profound spiritual experiences. Despite its potential benefits, Ibogaine's use is associated with cardiovascular risks and requires careful monitoring.

The Chemical Collective Episode 14: New Insights: Spring 2023 Recap and Future Directions of Neuroscience

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In this episode The Chemical Collective have an open discussion about some of the most interesting topics discussed over the semester and highlight the importance of ongoing research into the effects of drugs on the brain and society.

The Chemical Collective Episode 13: Alcohol Part 2 (Tequila)

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The origin of tequila, an alcoholic beverage made from the blue agave plant, can be traced all the way back to pre-Columbian times. In this episode The Chemical Collective expand on the impact that tequila has on the brain and body as well as its role in society.

The Chemical Collective Episode 12: Khat

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Khat is a flowering plant native to East Africa and the Arabian Peninsula used for centuries for its stimulating and euphoric effects. In this episode The Chemical Collective explore the world of Khat and discuss its active compound's effects on the brain and its role throughout history.

The Chemical Collective Episode 11: San Pedro

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San Pedro is a fast-growing cactus species with a rich history of use by indigenous peoples of the Andean region in their medicinal, spiritual, and religious practices. In this episode The Chemical Collective discuss the San Pedro cactus, its active compound’s effects on the brain, and its use in the past and present.