Today's episode is the first in a series of three that focus on inotropic and vasopressor medications used within anaesthetic practice. During this episode, we discuss metaraminol, ephedrine, phenylephrine, noradrenaline and adrenaline.

There's one section of our episode where we thought it important to clarify what we're saying, as to out ears it sounds a little confusing. During our discussion about adrenaline, we state that both noradrenaline and adrenaline have the same affinity for beta-1 adrenoceptors. We then advise that the reason for the inotropic and chronotropic effects of adrenaline - not seen with noradrenaline - are because adrenaline has much greater affinity for beta-2 adrenaceptors than noradrenaline.

Resources for today's episode:

StatPearls:
Inotropes and vasopressors by D. VanValkinburgh et al.
Adrenergic Drugs by K. Farzam et al.

LITFL:
Inotropes, vasopressors and other vasoactive agents by C. Nickson
Metaraminol by R. Buttner
Phenylephrine by C. Nickson
Noradrenaline by C. Nickson
Adrenaline by C. Nickson

Deranged Physiology:
Classification of inotropes and vasopressors
Metaraminol
Noradrenaline
Adrenaline

DRUGBANK Online:
Metaraminol
Ephedrine
Phenylephrine
Noradrenaline
Adrenaline

Feel free to email us at deepbreathspod@gmail.com if you have any questions, comments or suggestions. We love hearing from you!

And don't forget to claim CPD for listening if you are a consultant or fellow. Log us as a learning session which you can find within the knowledge and skills division, and as evidence upload a screenshot of the podcast episode.

Thanks for listening, and happy studying!

Today, we discuss a 2023 BJA Education article titled 'Perioperative care for transgender and gender diverse adults'. We start with a discussion of words and terms that are useful to understand, before diving in to discussions about a trauma-informed care approach to minimise and hopefully eradicate negative preoperative experiences, physical, chemical and surgical options for gender affirmation, and lastly how this can inform the provision of safe anaesthesia for transgender patients.

Resources for this episode:

BJA Education: Perioperative considerations for transgender and gender diverse adults by Harding, D. et al.

Feel free to email us at deepbreathspod@gmail.com if you have any questions, comments or suggestions. We love hearing from you!

And don't forget to claim CPD for listening if you are a consultant or fellow. Log us as a learning session which you can find within the knowledge and skills division, and as evidence upload a screenshot of the podcast episode.

Thanks for listening, and happy studying!

Today, in part 2 of our 2 part series on anaesthesia for previous heart transplant recipients, we discuss the care of these patients for non-cardiac surgery with special guest, Dr Ivan Rapchuk.

We begin by covering the electrophysiology of a transplanted heart and what you may see on the ECG, and then proceed to the management of our theoretical patient for general anaesthesia for non-cardiac surgery.

Resources for this episode:

Oxford Handbook of Transplant Anaesthesia and Critical Care

BJAED: Anaesthesia for a patient with a cardiac transplant (2002) by Morgan-Hughes, N. & Hood, G.

Circulation (2004): Drug therapy in the heart transplant recipient by Lindenfeld, J. et al.

Indian Journal of Anaesthesia: Post cardiac transplant recipient: Implications for anaesthesia by M. Choudhury

RCEM India Learning - The ECG after cardiac transplantation

Feel free to email us at deepbreathspod@gmail.com if you have any questions, comments or suggestions. We love hearing from you!

And don't forget to claim CPD for listening if you are a consultant or fellow. Log us as a learning session which you can find within the knowledge and skills division, and as evidence upload a screenshot of the podcast episode.

Thanks for listening, and happy studying!