A new study reveals how the frequency of your bowel movements could be an important indicator of your long-term health. Infrequent poopers showed signs of decreased kidney function, while those who went more often than average exhibited signs of impaired liver function. Listen in this week as Dee explains why the type and frequency of your bowel movements can affect your health well beyond the gut.

References:

Johnson-Martínez, J. P., Diener, C., Levine, A. E., Wilmanski, T., Suskind, D. L., Ralevski, A., Hadlock, J., Magis, A. T., Hood, L., Rappaport, N., & Gibbons, S. M. (2024). Aberrant bowel movement frequencies coincide with increased microbe-derived blood metabolites associated with reduced organ function. Cell Reports Medicine, 5(7), 101646. https://doi.org/10.1016/j.xcrm.2024.101646

Saccharomyces boulardii is a strain of probiotic yeast that was first isolated from the superfoods mangosteen and lychee fruit in 1923 by the French scientist Henri Boulard (hence the name). Today it is considered a "super probiotic" due to its unique properties and wide range of health benefits that set it apart from many other probiotic strains. Listen in this week as Dee discusses the key reasons why S. boulardii holds this distinction.

Link to Saccharomyces boulardii supplement: https://amzn.to/4cVqkVu

References:

Kaźmierczak-Siedlecka, K., Ruszkowski, J., Fic, M., Folwarski, M., & Makarewicz, W. (2020). Saccharomyces boulardii CNCM I-745: A non-bacterial microorganism used as probiotic agent in supporting treatment of selected diseases. Current Microbiology, 77(9), 1987–1996. https://link.springer.com/article/10.1007/s00284-020-02053-9

Studies show that obese individuals have more Firmicutes and fewer Bacteroidetes in their gut bacteria compared to those who are not overweight. Research suggests that consuming apple cider vinegar (ACV) can help improve this ratio. Listen in this week as Dee explains ACV's impact on the gut microbiome and its role in weight loss.

Link to Dee's Apple Cider Vinaigrette recipe: https://processedfreeamerica.org/dees-olive-oil-apple-cider-vinaigrette/

References:

Bouderbala, H., Dib, W., Kheroua, O., Saidi, D., & Kaddouri, H. (2019). Modulation of the intestinal microbiota by apple cider vinegar in rats subjected to cafeteria diet. Archives of Cardiovascular Diseases Supplements,11(3), e373-e374.https://doi.org/10.1016/j.acvdsp.2019.05.102

Davis C. D. (2016). The gut microbiome and its role in obesity. Nutrition Today, 51(4), 167-174.

https://doi.org/10.1097/NT.0000000000000167

Trimethylamine-N-oxide (TMAO) is a harmful compound produced by gut bacteria. Elevated TMAO levels can significantly influence the development of heart disease, type 2 diabetes, chronic kidney disease, cancer, and fatty liver disease. Listen in this week as Dee explains which foods increase the production of TMAO in the gut, and how you can optimize the health of your gut.

References:

Li, X. S., Obeid, S., Klingenberg, R., Gencer, B., Mach, F., Räber, L., Windecker, S., Rodondi, N., Nanchen, D., Muller, O., Miranda, M. X., Matter, C. M., Wu, Y., Li, L., Wang, Z., Alamri, H. S., Gogonea, V., Chung, Y. M., Tang, W. H., Hazen, S. L., … Lüscher, T. F. (2017). Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors. European Heart Journal, 38(11), 814–824. https://doi.org/10.1093/eurheartj/ehw582

Shan, Z., Sun, T., Huang, H., Chen, S., Chen, L., Luo, C., Yang, W., Yang, X., Yao, P., Cheng, J., Hu, F. B., & Liu, L. (2017). Association between microbiota-dependent metabolite trimethylamine-N-oxide and type 2 diabetes. The American Journal of Clinical Nutrition, 106(3), 888–894. https://doi.org/10.3945/ajcn.117.157107

The term "planetary health" refers to the natural systems that are essential for the health and survival of the human population. A commission of leading scientists from 16 countries have developed a "flexitarian" type diet designed to optimize human health and environmental sustainability on Earth. Listen in this week as Dee explains the parameters of the Planetary Health Diet and how it can improve your health.

Reference:

Healthy diets from sustainable food systems: Summary report of the EAT-Lancet Commission. (n.d.). https://eatforum.org/content/uploads/2019/07/EAT-Lancet_Commission_Summary_Report.pdf

A study examining ancient mummies from various countries revealed that one-third of them had atherosclerosis (plaques in the arteries), a precursor to heart disease, regardless of following Paleo-type or Mediterranean-type diets. This ratio mirrors what we see in modern populations. Listen in this week as Dee uncovers how we can harness the power of diet to overcome our genetic predispositions and lead healthier, heart-friendly lives.

Reference:

Thompson, R. C., Allam, A. H., Lombardi, G. P., Wann, L. S., Sutherland, M. L., Sutherland, J. D., Soliman, M. A.-T., Frohlich, B., Mininberg, D. T., Monge, J. M., Vallodolid, C. M., Cox, S. L., Abd el-Maksoud, G., Badr, I., Miyamoto, M. I., el-Halim Nur el-din, A., Narula, J., Finch, C. E., & Thomas, G. S. (2013). Atherosclerosis across 4000 years of human history: The horus study of four ancient populations. The Lancet, 381(9873), 1211–1222. https://doi.org/10.1016/s0140-6736(13)60598-x

A new study shows that a high-fat diet suppresses the expression of a protein called Jak3, which causes a cascade of inflammation that starts in the intestine, moves through the liver and on to the brain, ultimately causing Alzheimer's-like symptoms. Listen in this week as Dee discusses the results of this study and what it means for your health.

References:

Kumar, N., Mishra, J., Morales, R., & Kumar, P. (2024). Kinases in Gut-Liver-brain communication and neuroinflammation. Journal of Biological Chemistry, 300(3), 106750. https://www.jbc.org/article/S0021-9258(24)01223-7/fulltext

Glucagon-like peptide-1 (GLP-1) is a hormone naturally produced in the intestines during meals. It helps regulate blood sugar and weight by increasing insulin, slowing stomach emptying, and promoting fullness. Medications like Ozempic® and Wegovy® mimic the effects of GLP-1 but can be expensive and have unpleasant side effects. Listen in this week as Dee explores research on foods and probiotics that naturally boost GLP-1, offering similar benefits without the high costs and side effects.

References:

De Silva, A., & Bloom, S. R. (2012). Gut hormones and appetite control: A focus on PYY and GLP-1 as therapeutic targets in obesity. Gut and Liver, 6(1), 10–20. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286726/

Hira, T., Trakooncharoenvit, A., Taguchi, H.;,Hara, H. (2021). Improvement of glucose tolerance by food factors having glucagon-like peptide-1 releasing activity. International Journal of Molecular Sciences, 22(12), 6623. https://www.mdpi.com/1422-0067/22/12/6623

Perraudeau, F., McMurdie, P., Bullard, J., Cheng, A., Cutcliffe, C., Deo, A., Eid, J., Gines, J., Iyer, M., Justice, N., Loo, W. T., Nemchek, M., Schicklberger, M., Souza, M., Stoneburner, B., Tyagi, S., & Kolterman, O. (2020). Improvements to postprandial glucose control in subjects with type 2 diabetes: A multicenter, double blind, randomized placebo-controlled trial of a novel probiotic formulation. BMJ Open Diabetes Research and Care, 8(1), e001319. https://drc.bmj.com/content/8/1/e001319

Link to purchase GLP-1 Probiotic: https://pendulumlife.com/products/glp-1-probiotic