Good Clincal

De: Charles Beasley
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  • Resumen

  • The world of emerging medical technologies is vast and continuously evolving.

    Join host Charles Beasley as he discusses the future of medicine and human health with the best and brightest in these fields.

    New episodes weekly.

    #goodclinical #goodclinicalpodcast #goodclinicalnetwork #goodclinicalexplains #goodclinicalevents
    Hendrik Clinical Research Consulting Ltd
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Episodios
  • Ep 30 - Dr Vickie Shim - Personalized Treatment Plans after Mild Traumatic Brain Injury

    Ep 30 - Dr Vickie Shim - Personalized Treatment Plans after Mild Traumatic Brain Injury
    Jul 29 2024
    Good Clinical has teamed up with Te Titoki Mataora, the MedTech Research Translator, to bring you the Te Titoki Mataora Podcast Series.

    In this epsiode, Dr. Vickie Shim, a Senior Research Fellow at the Auckland Bioengineering Institute, discusses her work in neuromechanics and its application to injury and degenerative diseases, specifically mild traumatic brain injury (TBI). She explains that neuromechanics focuses on how brain tissue responds to external mechanical stimuli, such as impacts, and the potential damage that can occur.

    Dr. Shim's research involves studying the brains of high school rugby players throughout a season to track brain changes and correlate them with head impacts. The goal is to develop an AI-based tool that can predict recovery trajectories and inform personalized treatment plans for individuals with TBI.

    Podcast Takeaways:
    1. Neuromechanics focuses on how brain tissue responds to external mechanical stimuli, such as impacts.
    2. Mild traumatic brain injury (TBI) is a common form of TBI, with about 80% of all TBIs falling into the mild range.
    3. Repetitive head impacts, such as those experienced in contact sports or by combat soldiers, can lead to long-term brain degenerative changes and increased risk of neurodegenerative diseases.
    4. Dr. Shim's research involves studying the brains of high school rugby players to track brain changes over a season and correlate them with head impacts.
    5. The goal is to develop an AI-based tool that can predict recovery trajectories and inform personalized treatment plans for individuals with TBI.

    Timestamps:
    00:00 Introduction to Neuromechanics and Dr. Vickie Shim's Research
    01:22 Understanding Brain Tissue Response to Mechanical Impact
    06:22 The Prevalence and Impact of Mild Traumatic Brain Injury
    10:06 Tracking Brain Changes in High School Rugby Players
    19:04 Developing an AI-Based Tool for Predicting Recovery Trajectories 2
    6:40 Personalized Treatment Plans for Mild Traumatic Brain Injury
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    35 m
  • Ep 29 - Dr Maddie White - The Role of Translational Scientists in Creating Real-World Impact

    Ep 29 - Dr Maddie White - The Role of Translational Scientists in Creating Real-World Impact
    Jul 15 2024
    Today’s guest is Dr Maddie White, Translational Scientist and Strategic Partnerships Manager at the Gillies McIndoe Research Institute in Wellington, New Zealand.

    This episode is brought to you by SAPRO Consulting.

    Dr. Maddie White, a translational scientist and strategic partnerships manager at Gillies-McIndoe Institute, discusses the role of translational scientists in moving research from the lab to real-world impact. She emphasizes the importance of translating academic ideas into commercially viable products or services.

    Dr. White shares her personal journey into translational science and highlights the need for more awareness and education about career opportunities in this field. She also discusses a specific project she is involved in, developing a topical cream for the treatment of vascular birthmarks in infants.

    Dr. White emphasizes the need for talent, infrastructure, and funding to drive the success of translational science in New Zealand.

    You can find out more about Dr White and The Gillies McIndoe Research Institute here:
    LinkedIn - Maddie White
    Website - Gillies McIndoe Research Institute

    Podcast Takeaways:
    1. Academic ideas need to be translated into commercially viable products or services to have a meaningful impact.
    2. A "translational scientist" is someone who takes scientific ideas from the lab and translates them into real-world products or services.
    3. Translational scientists play a crucial role in moving research from the lab to real-world impact.
    4. There is a need for more awareness and education about career opportunities in translational science.
    5. Talent, infrastructure, and funding are essential for the success of translational science.
    6. Partnerships between academia and industry are key in driving the translation of research into practical applications.

    Chapters
    00:00 Introduction to Translational Science
    01:00 Translating Academic Ideas into Real-World Impact
    08:04 Overcoming Stigma and Misconceptions
    13:18 The Importance of Money in Translational Science
    19:49 Creating Collaborative Networks for Impactful Research
    23:58 Developing a Topical Cream for Vascular Birthmarks
    26:21 Partnerships for Bringing Research to Market

    Keywords:
    Translational science, research, lab, real-world impact, commercialization, academic, funding, talent, infrastructure, money, partnerships, topical cream, vascular birthmarks


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    40 m
  • Ep 28 - Dr Victor Dieriks - Early Detection of Parkinson's Diseases

    Ep 28 - Dr Victor Dieriks - Early Detection of Parkinson's Diseases
    Jul 7 2024
    Good Clinical has teamed up with Te Titoki Mataora, the MedTech Research Translator, to bring you the Te Titoki Mataora Podcast Series.

    Today’s guest is Dr Victor Dieriks, the Head of the Apha Synuclein Lab at the Centre for Brain Research at the University of Auckland. Dr Dieriks studies the role of alpha synuclein in the development of Parkinson's Disease and Multiple System Atrophy (MSA).

    Parkinson’s disease (PD) is currently the fastest-growing chronic neurological disorder globally. An estimated 12 million people are living with PD, with around 12,000 of those residing in New Zealand.

    Unfortunately, no treatments presently target the underlying mechanisms of PD, and clinical studies aimed at discovering disease-modifying medications are limited. This means that a truly effective, curative treatment remains years away. However, numerous interventions are available today that can significantly improve the quality of life for those with PD.

    Dr Victor Dieriks has two active projects with Te Titoki Matora, MedTech Research Translator
    1. Project #1: Developing a more New Zealand-centric approach to the management and treatment of Parkinson's disease. Dr Dieriks emphasizes the importance of actively involving patients and understanding their priorities, rather than solely relying on the perspectives of healthcare professionals and researchers.Patients1 with PD often express their desire for improved dignity and quality of life, rather than just a focus on a cure or restoring mobility.
    2. Project #2: involves the use of tears (eye fluid) as a potential biofluid source for detecting Parkinson's disease biomarkes. Tears are a relatively pure and stable biological fluid, making them a promising target for developing a non-invasive diagnostic test that can be easily obtained. A core aspect of this project is reducing the burden on the healthcare system, particularly the long wait times to see a neurologist for diagnosis. By developing a simple, tear-based test, patients can potentially bypass the need for more invasive procedures and receive earlier prognosis and treatment.
    Podcast Takeaways:
    1. Parkinson's disease is not a single disease, but rather a collection of diseases with multiple causes
    2. The normal function of alpha-synuclein is not fully understood, but it is known to play a role in neuronal communication and potentially in the gut and microbiome
    3. Current treatments for Parkinson's, like levodopa and deep brain stimulation, only address the symptoms and cannot stop the underlying disease progression
    4. A major challenge is that current therapies are tested too late, only after 70% of the relevant neurons have already died.
    5. Early detection is key, and recent breakthroughs have shown that alpha-synuclein clumps can be detected in spinal fluid or even potentially in less invasive samples like skin or nasal swabs, years before symptom onset
    6. While genetic risk factors can be screened for, they only account for a small percentage of Parkinson's cases. Other risk factors include environmental exposures like metals, pesticides, and viral/bacterial infections that cause inflammation
    7. In the absence of a cure, lifestyle interventions like exercise, healthy eating, and moderate coffee consumption can help delay the onset and progression of Parkinson's. Exercise, in particular, has been shown to have neuroprotective effects mediated by the hormone irisin.
    8. The gut-brain axis is also implicated in Parkinson's, with constipation and other gut symptoms often preceding the motor symptoms.
    Chapters
    0:00 Introduction
    01:10 "Parkinson's Disease" is a misnomer
    02:50 Dieriks Lab Focus
    06:00 Peculiarities of Neurodegenerative Diseases
    09:00 Role of alpha synuclein
    14:00 Treatment's available for Parkinson's Disease
    19:00 Risk factors for Parkinson's Disease
    24:00 Alternative sampling methods for determining risk of
    PD 27:20 Interventions for slowing development
    31:00 Coffee
    32:12 Gut-brain Axis
    35:25 New Zealand-centric approach to management and treatment of PD 39:00 Importance of having all stakeholders engaged
    44:30 Tears can predict risk of Parkinson's Disease?

    Keywords: Parkinson's Disease, TTM, Te Titoki Mataora, biomedical science, research, research translation, medtech, medical technologies, university research, intellectual property, commercialization.

    Early Detection of Parkinson's Diseases | Dr Victor Dieriks | TTM Ep02
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    49 m
Enfermedades Físicas Hygiene & Healthy Living Política y Gobierno Ciencias Biológicas
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