Dr. Coleen Murphy is a prominent aging researcher and author of the upcoming book “How We Age: The Science of Longevity” from Princeton University Press. In this wide-ranging discussion, Coleen provides insights into her motivation for writing this book, key topics covered, and her unique perspective on the field.

Key ideas:

• Addressing ethical concerns about studying aging and longevity
• Defining aging conceptually and how metrics like lifespan vs. healthspan are measured
• Using genetics, transcriptomics and other tools to understand molecular changes in aging
• The prominent role of reproduction and sex differences in aging
• Theories on tradeoffs between reproduction and longevity
• Genetics of aging pathways including insulin/IGF-1, mTOR, and sirtuins
• Cellular processes involved in aging such as mitochondrial dysfunction, epigenetic changes, senescence
• The importance of models like C. elegans and Drosophila in aging research
• Ongoing research and future potential for interventions to increase healthspan
• The challenge of complex science without excessive jargon
• Highlighting critical contributions by women scientists in the field
• Omitting personal lifestyle advice and focusing on evidence-based science
• The rapid pace of advancement in biotech applications of longevity science

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