• How to Get to Clinically Relevant Research (10)

  • Mar 26 2021
  • Duración: 18 m
  • Podcast

How to Get to Clinically Relevant Research (10)

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  • How to Get to Clinically Relevant Research The default method to evaluate clinical research is by statistical significance  Unfortunately is statistical significance not related to the meaningfulness of the findings in the research and thereby to its meaningfulness for patients and healthcare If researchers stated ahead of starting the trial what they would consider clinically relevant,  the reader could relate to that and agree or disagree with the researcher It would come from focusing on using the provided information to help patients and improve healthcare - and not just publishing a paper We want to make it mandatory to state the researchers' clinical relevance levels ahead of the trial, mentioning what they will consider clinically relevant when they pre-register their research on the clinicaltrials.gov website or similar websites. They then need to compare their findings in both the paper and abstract when publishing data from the study.    #clinicalrelevance   LINKS: A specific page on our website about requesting clinical relevance statement and evaluation https://www.precision-evidence.com/p/clinical-relevance/  The history behind the chosen level for statistical significance with Ronald Fisher's book from 1925 "Statistical Methods for Research Workers." Precision Evidence Blog: https://www.precision-evidence.com/blog/the-p-value-and-sir-ronald-fischer/   96% of published studies mention a p-value at 0.05 or lower: "What Have We (Not) Learned from Millions of Scientific Papers with P Values?" https://www.tandfonline.com/doi/full/10.1080/00031305.2018.1447512  Overview of clinical trials registers like clinicaltrials.gov: https://sites.google.com/a/york.ac.uk/yhectrialsregisters/home/clinicaltrials  Only 15% of clinical research brings value: “Avoidable waste in the production and reporting of research evidence”  https://pubmed.ncbi.nlm.nih.gov/19525005/   Precision Evidence #8: "Critical Appraisal of the Moderna COVID19 Vaccine Trial"  https://www.precision-evidence.com/8   Precision Evidence #6: "Covid-19 Vaccines Trials: Understanding the First Published Results"  https://www.precision-evidence.com/6   Precision Evidence #5: "Covid-19 Vaccines Trials and Press Releases – Looking Beyond the Efficacy"  https://www.precision-evidence.com/5  TED talk with Sir Ken Robinson where he talks about two kinds of people  https://www.ted.com/talks/sir_ken_robinson_bring_on_the_learning_revolution    NOTES:  Statistical significance vs. clinical significance in clinical researchClinical significance, clinical relevance, clinical meaningfulnessShould clinical significance be used instead of statistical significance, or should they be used together?Problems with statistical significanceProblems with clinical significanceWhy researchers must state what they consider clinical relevant outcomes before starting a research project and refer back to that when evaluating their findings"Positive" vs. "negative" trials in terms of statistical significance and why all research mattersOverrepresentation in published research of statistically significant findings with p-values at 0.05 or lowerEfficacy measures with examples "Number Needed to Treat" (NNT) of "Number Needed to Harm" (NNH)The history behind the chosen level for statistical significance with Ronald Fisher's book from 1925 "Statistical Methods for Research Workers."  See also blog: Peer-reviewers responsibilityWe want to make it mandatory to state clinical relevance levels by the researchers ahead of the trial, mentioning what they will consider clinically relevant and essential when they pre-register their research on the clinicaltrials.gov website or similar websites. They then need to compare their findings with that both in the paper and abstract when publishing data from the researchALWAYS ASK FOR A CLINICAL RELEVANCE EVALUATION OF THE RESULTS - every time, all of us, whatever relation we have to produce, read and use information from clinical researchASK FOR A CLINICAL RELEVANCE EVALUATION OF THE RESULTS - and let's make it just as normal as the p-value #clinicalrelevance   GET THE ABSTRACT SCREENING TOOL It can be a challenge to screen papers for clinical relevance. As we go beyond the abstract in this podcast, we have created a screening tool you can use when reading an abstract from a clinical research paper. Using that tool enables you to quickly screen an abstract from a medical journal for clinical relevance selecting only those you want to read. At the same time, you will know why you skipped the rest. Get it at our website https://www.precision-evidence.com    Contact us at email: podcast@precision-evidence.com, Twitter @PrecisionEBM, You can learn more at our website, where you can also leave us a voice message Website: www.precision-evidence.com Get the Precision Evidence Newsletter https://bit.ly/3tLBx3Z   Hosts: Dr. Kim Kristiansen, M.D: @KKristiansenMD JG Staal: @HealthyEvidence   Music thanks...
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