• Principles
• Case #1
• Case #2

Key Concepts:

• Patient education about the disease and its natural history if left untreated is important

• Interprofessional, multidisciplinary care is associated with the best patient outcomes

• Team-based care
• Treatment
• • General care
  • Prevention
  • Symptomatic treatment
  • Cenegermin
  • • Safety, efficacy, role in treatment/patient selection
    • Cost
    • Storage and administration
  • Corneal neurotization
  • Investigational therapies

Key Concepts:

• Most patients should receive basic preventive and symptomatic care, as well as active treatment in certain cases

• Cenegermin promotes corneal healing and is the only medication approved for the treatment of patients with neurotrophic keratitis

• Clinical manifestations
• Screening
• Tools to test corneal sensitivity
• Diagnostic algorithm
• Disease staging
• Considerations for referral

Key Concepts:

• Patients who are candidates for screening include those with a variety of genetic, system, central nervous system, or ocular diseases, such as diabetes mellitus, multiple sclerosis, and Alzheimer’s disease, or who us contact lenses or eyedrops with preservatives

• Corneal sensitivity can be tested various ways and is critical to make the diagnosis
• Cenegermin is self-administered and requires the patient be thoroughly educated regarding storage, handling, and administration