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About the guest: Maxime Aubert, PhD is a geochemist & archeologist at Griffiths University in Australia. He specializes in the application of advanced analytical techniques to date the age of ancient rock art and hominin fossils.

Episode summary: Nick and Dr. Aubert discuss: the oldest known cave art and what it depicts; human evolution & interbreeding with different human sub-species; the origins of anatomically modern humans & advanced cognition; and more.

Related episodes:

• M&M #126: Evolution of Human Behavior, Anatomy & Diet, Homo naledi & the Cave of Bones | John Hawks
• M&M #38: Human Evolution, Homo Naledi, Ancient Drug Use, Ritual Burials, Origins of the Human Mind | Lee Berger

*This content is never meant to serve as medical advice.

Support the show

All episodes (audio & video), show notes, transcripts, and more at the M&M Substack

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• MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils, artificial ingredients, etc. Use code MIND for 20% off.
• SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.
• Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off.
• Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.

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About the guest: Nick Jikomes, PhD is the creator and host of the podcast. You can read more about him here.

Episode summary: Nick answers questions from listeners are topics such as: his scientific background & interests; staying up-to-date on research & selecting guests; thoughts on psychedelic science & drug use; questions related to diet, metabolic health & fat loss; controversial ideas worth considering; and more.

*This content is never meant to serve as medical advice.

Support the show

All episodes (audio & video), show notes, transcripts, and more at the M&M Substack

Affiliates:

• MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils, artificial ingredients, etc. Use code MIND for 20% off.
• SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.
• Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off.
• Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.

Learn all the ways you can support my efforts

Send us a text

About the guest: June Round, PhD is a microbiologist whose lab at the University of Utah studies microbiome-host interactions, gut microbiota, immunity, metabolism, obesity, and other disorders.

Episode summary: Nick and Dr. Round discuss: how the immune system and gut microbiome interact; dietary fiber & short-chain fatty acid production by gut microbes; nutrient absorption; obesity & metabolic syndrome; type I diabetes; cleanliness, development & the “hygiene hypothesis”; and more.

Related episodes:

• M&M #133: Infant Microbiome & Breast Milk, Oral Microbiome & Cavities, Gut Health, Fiber, Probiotics, Diet, Sex Hormones, Soy Foods & Estrogens | Carolina Tropini
• M&M #103: Connections Between Microbiome, Exercise, Diet, Metabolism, Circadian Rhythms, Endocannabinoids & Health | Christoph Thaiss

*This content is never meant to serve as medical advice.

Support the show

All episodes (audio & video), show notes, transcripts, and more at the M&M Substack

Affiliates:

• MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils, artificial ingredients, etc. Use code MIND for 20% off.
• SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.
• Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off.
• Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.

Learn all the ways you can support my efforts

Send us a text

About the guest: Gregory Scherrer, PharmD, PhD is a neuroscientist whose lab at the University of North Carolina studies the neural basis of pain, including its sensory, emotional, and cognitive components.

Episode summary: Nick and Dr. Scherrer discuss: the neural basis of pain sensation & pain perception; opioids & the opioid system; cognitive modulation of painful experiences; neural basis of placebo effects; endogenous opioid system; and more.

Related episodes:

• M&M #52: Pain Drugs, NSAIDs, Opioids, Oxycodone, Heroin, Fentanyl & the Neuroscience of Pain | David Roberson
• M&M #159: Neuroscience of Social Behavior, Pain, Empathy, Emotion, Brain Mechanisms of MDMA | Monique Smith

*This content is never meant to serve as medical advice.

Support the show

All episodes (audio & video), show notes, transcripts, and more at the M&M Substack

Affiliates:

• MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils, artificial ingredients, etc. Use code MIND for 20% off.
• SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.
• Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off.
• Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.

Learn all the ways you can support my efforts

Send us a text

Special episode: Episodes in the Independent Scholars (IS) series are available in full to paid subscribers on the M&M Substack. This is a free, partial version.

About the guest: Steven Rofrano became interested in human health & food, including ancestral vs. modern diets, from personal experiences in diet & allergies during college. He is co-founder and CEO at Ancient Crunch, Inc., which provides alternatives to widely consumed ultra-processed snack foods. Before becoming an entrepreneur Steven studied mathematics at Yale University and worked as a software engineer.

Episode summary: Nick and Steven discuss: ancestral vs. modern foods; seed oils & polyunsaturated fatty acids (PUFAs); inflammation, allergies, and immunity; PUFAs, free radicals, and oxidative stress; the corrupting influence of private industry on food science; the history of seed oils; animal vs. plant fats; Steven’s food startup; and more.

Related episodes:

• M&M #176: Bad Science, Nutrition Epidemiology, History of Obesity Research, Diet & Metabolic Health | Gary Taubes
• M&M #136: Seed Oils, Omega-6 PUFAs, Inflammation, Obesity, Diabetes, Chronic Disease & Metabolic Dysfunction | Chris Knobbe

*This content is never meant to serve as medical advice.

Support the show

All episodes (audio & video), show notes, transcripts, and more at the M&M Substack

Affiliates:

• MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils, artificial ingredients, etc. Use code MIND for 20% off.
• SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.
• Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off.
• Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.

Learn all the ways you can support my efforts

Send us a text

About the guest: Gary Taubes is a researcher, science historian, and science journalist. He has written several books, including “Rethinking Diabetes.”

Episode summary: Nick and Gary Taubes discuss: the field of nutrition epidemiology and why it’s filled with so much junk science; social factors influencing scientific research; the history of obesity & diabetes research; the energy balance vs. carbohydrate-insulin models of obesity; fats, carbs & insulin resistance; and more.

Related episodes:

• Obesogens, Oxidative Stress, Dietary Sugars & Fats, Statins, Diabetes & the True Causes of Metabolic Dysfunction & Chronic Disease | Robert Lustig | #140
• Obesity Epidemic, Diet, Metabolism, Saturated Fat vs. PUFAs, Energy Expenditure, Weight Gain & Feeding Behavior | John Speakman | #132

*This content is never meant to serve as medical advice.

Support the show

All episodes (audio & video), show notes, transcripts, and more at the M&M Substack

Affiliates:

• MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils, artificial ingredients, etc. Use code MIND for 20% off.
• SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.
• Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off.
• Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.

Learn all the ways you can support my efforts

Send us a text

About the guest: Austin Argentieri, PhD is a researcher in the Analytic & Translational Genetics Unit at the Massachusetts General Hospital with academic appointments at Harvard & the Broad Institute. His research focuses on large-scale analyses to to understand human aging.

Episode summary: Nick and Dr. Argentieri discuss: chronological vs. biological age; DNA methylation and aging clocks; proteomics and protein measurements in aging research; health, longevity, and human healthspan; and more.

Related episodes:

• Aging, mTOR, Sirtuins, Rapamycin, Metformin, the Truth of Resveratrol & Longevity Supplements, David Sinclair & Anti-Aging Myths | Matt Kaeberlein | #151
• Cellular Aging, Taurine, Nutrition, Senescence, Longevity, Mitochondria, Metabolism | Vijay Yadav | #122

*This content is never meant to serve as medical advice.

Support the show

All episodes (audio & video), show notes, transcripts, and more at the M&M Substack

Affiliates:

• MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils, artificial ingredients, etc. Use code MIND for 20% off.
• SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.
• Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off.
• Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.

Learn all the ways you can support my efforts

Send us a text

About the guest: Sean Hartig, PhD is an associate professor at the Baylor College of Medicine, where is lab studies adipose (fat) tissue, metabolic regulation, and obesity & energy balance disorders.

Episode summary: Nick and Dr. Hartig discuss: visceral vs. subcutaneous fat; white, brown, and beige adipose tissue; physiology of fat cells; obesity, insulin resistance, and leptin resistance; hormones & fertility; GLP-1 drugs for weight loss; and more.

Related episodes:

• Obesogens, Oxidative Stress, Dietary Sugars & Fats, Statins, Diabetes & the True Causes of Metabolic Dysfunction & Chronic Disease | Robert Lustig | #140
• GLP-1, Weight Loss Drugs, Ozempic, Obesity, NMDA Receptors, Metabolism & Brain Health | Christoffer Clemmensen | #161

*This content is never meant to serve as medical advice.

Support the show

All episodes (audio & video), show notes, transcripts, and more at the M&M Substack

Affiliates:

• MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils, artificial ingredients, etc. Use code MIND for 20% off.
• SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.
• Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off.
• Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.

Learn all the ways you can support my efforts