Prof Sonia Gandhi joined us to share her expertise on how Mitochondria affects PD with an excellent presentation followed by a very probing Q&A by our well informed audience.

Prof Gandhi is a leading expert in the process of protein misfolding, in which smaller proteins, monomers, join together to form larger proteins, oligomers, and how this process may drive organellar dysfunction and cell toxicity in neurodegeneration.

Sonia obtained a BA in Neuroscience at Trinity College, University of Cambridge, in 1996, and completed her degree in Medicine at New College, University of Oxford, in 1999. She trained in postgraduate medicine at the Hammersmith Hospital, Royal Brompton Hospital, National Hospital for Neurology and Neurosurgery, and Whittington Hospital.
Sonia was awarded a Wellcome Clinical Research Training Fellowship to complete a PhD in Neuroscience at UCL Institute of Neurology in 2004. In 2007, she trained as a Specialist registrar in Neurology, and took up an NIHR Lectureship in Neurology at Imperial College in 2009. In 2012 she was awarded a Wellcome Trust Intermediate Clinical Fellowship, and established her laboratory at the UCL Institute of Neurology in October 2013. She was awarded a laboratory secondment to the Francis Crick Institute in 2016

We had the pleasure of a presentation by Dr Jonathan Sackner-Bernstein, MD, on the topic of "Why I am optimistic that we might now have a Silver Bullet for Parkinson's", followed by a Q&A session of almost 50 probing questions from our audience.

Dr. Jonathan Sackner-Bernstein is transforming the treatment of Parkinson’s disease (PD). First, he discovered that the brain cells (dopaminergic neurons) in Parkinson’s patients are exposed to excess dopamine, reaching toxic levels. Next, he identified a drug that reverses disease pathology by reducing dopamine levels in 10 studies using laboratory models of PD

As an academic physician, Sackner-Bernstein leverages lessons learned at the US Food and Drug Administration (where he received 2 Commission’s Awards) and the US Defense Advanced Research Projects Agency (in a central role for the launch of the US Biological Technologies Office with its initial focus on neurotechnology).

Jonathan’s history of identifying contrarian views is remarkable for consistently being proven correct by subsequent studies and analyses. His optimism that PD will be conquered by reducing dopamine is supported by scientific data. And this drug therapy is poised to enter Phase 2 clinical trials, with data as soon as 6 months following trial launch.

More about the speaker:-

Dr Sackner-Bernstein is soon to launch a Blog to provide updates so please register here https://www.parkinsonsdisease.blog/

A new website has also been launched by Dr Sackner-Bernstein on which you will see his distinguished team including two of our previous speakers, Prof Roger Barker who spoke o Cell replacement therapy and Dr Lorraine Kalia more recently sharing her expertise on Drug replacement so take moment to watch those recordings here on our channel or listen to them on Spotify

https://www.rightbrainbio.com/

We had the pleasure of interviewing Dr Michael Okun on the topic of "Practical strategies for living a happier life with Parkinson's".

Dr Okun is a worldwide recognised leader on Parkinson’s disease, is the distinguished Professor of Neurology and Director of the Norman Fixel Institute for Neurological Diseases at the University of Florida Health. The UF institute he co-founded with Kelly D. Foote, M.D. is a one-stop patient-centred clinical-research experience for national and international patients seeking care.

Dr. Okun has served as the National Medical Director/Advisor for the Parkinson’s Foundation since 2006. His research has been wide ranging and he is best known for his exploration and innovation in neuromodulation and deep brain stimulation.

He has published over 600 peer-reviewed articles and his book, “Parkinson's Treatment: 10 Secrets to a Happier Life” was translated into over 20 languages. His most recent books are “Ending Parkinson’s Disease” and “Living with Parkinson’s Disease”.

Dr. Okun was recognized in a 2015 White House ceremony by the Obama administration as a Champion of Change for Parkinson’s Disease

We were delighted to host Dr Michelle Sexton who presented on the topic of "How can medical cannabis help people with Parkinson's" and here is the recording of the event.

About the speaker:-

Dr. Sexton is an integrative medicine specialist and respected pioneer in the field of medical cannabis. She has over thirty years of experience as a midwife, herbalist, and naturopathic doctor. She completed a postdoctoral fellowship at the University of Washington in the Departments of Pharmacology/Psychiatry and Behavioural Sciences. There, she studied the endocannabinoid system and its roles in neuro-inflammation and neuro-degeneration.

To find out more about Michelle here:-

Website :- https://www.ecsdoctor.com/
Website for scheduling a patient consultation is https://www.msextonnd.com/
Instagram :- / dr.michellesexton (@dr.michellesexton)
Facebook: / msextonnd
Michelle's latest book can be found here :- https://shop.ingramspark.com/b/084?U0...

IF YOU CAN, PLEASE DONATE TO NO SILVER BULLET 4PD.

We are self-funded, so pay for our costs ourselves, which include licenses for our secure Webinar platform, our Podcast hosting platform etc , in the hope that some of our speaker's content, may improve the symptoms of another PwP

Thank you & just follow this link:-
https://www.paypal.com/donate/?hosted....

We were delighted to host Prof Christine Klein who talked to us about "The importance of genetics in finding a cure for Parkinson's".

It was a really interesting presentation and followed by a very good Q&A with excellent questions from you our audience, so thank you.

It is now a very worthwhile Podcast and video (on our YouTube Channel https://www.youtube.com/channel/UCN2A0vGOY6j13Ed1rV64gPQ/featured ) to help understand more about this important topic.

About the speaker:-

Christine Klein is a professor of neurology and neurogenetics. She studied medicine in Hamburg, Heidelberg, Luebeck, London, and Oxford before moving to Boston from 1997 to 1999 for a fellowship in molecular neurogenetics. She completed her neurology training at Luebeck University in 2004, followed by a series of summer sabbaticals in movement disorders in Toronto, Canada in 2004 to 2015. Her research has focused on the clinical and molecular genetics of movement disorders and its functional consequences. In 2009, Dr. Klein became director of the newly founded Institute of Neurogenetics in 2013 in Luebeck, Germany.

Prof. Klein has published more than 500 scientific papers. She is deputy editor of ‘Movement Disorders’ and associate editor of ‘Annals of Neurology’ and serves as acting past president of the German Neurological Society. Ten of her former mentees have been promoted to the level of assistant, associate or full professor.

Find out more about Christine and her great work here:-

https://www.neurogenetics-luebeck.de/...

https://www.michaeljfox.org/researche...

https://www.youtube.com/watch?v=6xVPl...

https://www.youtube.com/watch?v=zDkaJ...

https://www.linkedin.com/in/christine...

We are excited to share our latest interview with you all, in which Dr Raul Martinez- Fernandez explains the therapy of Focused Ultrasound, a therapy that offers appropriate candidates with an alternative to the more intrusive DBS. It is of course not a replacement for DBS, simply an alternative offering a solution for those with differing symptoms.

More about Dr Martinez-Fernandez:-

Dr Raul Martinez-Fernandez is a neurologist and clinical researcher, Associate Professor of Medicine at the Neuro research Centre HM CINAC; HM Puerta del Sur Hospital; CEU San Pablo University, Spain.

After getting his neurology diploma in Spain in 2008, he trained at the Deep Brain Stimulation department of the National Hospital of Neurology and Neurosurgery – Queen Square (London). Subsequently, he attended a 2-year fellowship in Grenoble (France), the birthplace of modern Functional Neurosurgery, under the wings of Professors Paul Krack and Elena Moro. In Grenoble, he started his PhD in Medical Science that he obtained in 2017. Since 2015 he is coordinator of the high intensity focused ultrasound program in HM CINAC (Madrid), directed by Prof Obeso.

He has published several papers on the topic of focused ultrasound in Lancet Neurology and The New England Journal of Medicine. The experience gathered has allowed him to be invited for lecturing worldwide, to provide support to teams which are starting to use the technique, and to receive several research awards.

We are delighted to host Dr. Simon Stott again in what is becoming our regular start to the year's presentations. And what better way than to hear Dr. Stott's main PD research takeaways from 2023 and research results he will be looking for in 2024.

For those of you who are unfamiliar with Dr. Stott's work, Dr Stott is the Director of Research at Cure Parkinson's. The trust is an international supporter of both lab- and clinic-based research on Parkinson's and aims to find treatments that will slow, halt or reverse the condition.

Originally from New Zealand, Simon has more than 20 years of experience in the field of Parkinson's research - in both the academic and biotech sectors. He has been involved in lab-based research as well as clinical studies.

He also maintains the 'Science of Parkinson's' website (https://scienceofparkinsons.com/about/), which explains in plain English the research currently being conducted on Parkinson's.

IF YOU CAN, PLEASE DONATE TO NO SILVER BULLET 4PD.

We are self-funded, so pay for our costs ourselves, which include licenses for our secure Webinar platform and our Podcast hosting platform so that we can target and share these sessions with more PwP worldwide, in the hope that some of our speaker's content, may improve the symptoms of another PwP

Thank you & just follow this link:-
https://www.paypal.com/donate/?hosted...

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Light Therapy is an area of great interest and hope for PwP worldwide, as shown by the viewing numbers for our 3 previous NSB4PD sessions over the last 48 months.

Here in this interview with Dr Wayne Markman, CEO of SYMBYX, we explore how photobiomodulation devices directly address the gut, vagus nerve and brain.

SYMBYX's mission is to develop medically approved light therapies to reduce chronic Parkinson’s symptoms - early trials and clinical data show improvements across a range of symptoms and with a very high safety profile. SYMBYX are committed to increasing clinical trial evidence supporting light therapy as a complementary and effective intervention that fits into a person with Parkinson's medication, healthy diet and exercise regime.

About the speaker:-

Dr. Wayne Markman is South African-born and emigrated to the US in 1986 and then to Australia in 2000. Dr. Markman obtained a BA in Economics from Macalester College in 1991 and an MBA from Harvard University in 1996; worked as an investment banker, he decided to pursue a career in medical science at Macquarie University in Sydney, specialising in neuroscience and movement disorders.

Dr. Markman worked in a physiotherapy clinic before founding SYMBYX, a company dedicated to developing light therapy devices to alleviate the impact of chronic conditions like Parkinson's.

He has been personally affected by PD with several close family members diagnosed previously, so this research has added meaning and focus for him

With a focus on the gut-brain axis, SYMBYX is committed to providing complementary and effective interventions for Parkinson's patients worldwide.

By next year, SYMBYX will have completed 4 clinical trials with publications in leading peer reviewed journals and commenced 3 additional large scale randomised control trials investigating motor, non-motor and medication efficacy implications of infrared laser treatment to the gut.

This is SYMBYX's website :- https://symbyxbiome.com/

IF YOU CAN, PLEASE DONATE TO NO SILVER BULLET 4PD.

We are self-funded, so pay for our costs ourselves, which include licenses for our secure Webinar platform, our Podcast hosting platform so that we can share these sessions with more PwP worldwide, in the hope that some of our speaker's content, may improve the symptoms of another PwP

Thank you & just follow this link:-
hhttps://www.paypal.com/donate/?hosted...

If you want to join our mailing list for future speaker sessions then please email us at nosilverbullet4pd@gmail.com