Weight loss peptides are gaining popularity due to their pharmacological strength and safety. The main category of weight loss peptides is appetite suppressants, with GLP-1 medications like semaglutide and tirzepatide being the most popular. Another appetite suppressant called tesofensine is also effective. Fat mobilizing peptides, such as growth hormone secretagogues and AOD 9604, help protect muscle mass during weight loss. It is important to combine peptide therapy with resistance training and adequate protein intake to prevent muscle loss. Peptides like MOTC and tesofensine also have additional benefits for mitochondrial health and cognitive function. The most effective lifestyle strategies to complement peptide therapy are a healthy diet with less processed foods and intermittent fasting. The conversation covers the topics of nutrition, fasting, and maintaining weight loss. Dr. J emphasizes the importance of reducing processed foods and increasing whole, unprocessed foods in the diet. He also discusses the benefits of fasting, particularly longer fasting periods of 24-48 hours. Dr. J recommends a combination of nutrition, fasting, resistance training, supplements, stress management, and sleep optimization for lasting weight loss. He shares his own experience of maintaining a lean physique and highlights the importance of fixing hormonal imbalances and adopting a sustainable lifestyle.