Comedy legend Cathy Ladman (@cathyladman1) joins Jesse, Andy and Matt to talk about creepy Foundation for a Better Life billboards, cancer battles, 1970s acid, the CrowdStrike software crash, how propofol tips your brain into chaos, the merits of comedy classes, Brazilian cocaine sharks and Cathy's September 7th Vegas show.

Producer David Brown joins Jesse, Matt and Andy to talk about creating entertaining science programming, the new Peacock show The Hungry Games: Alaska's Big Bear Challenge that David produced, Rhys Darby narrated and Matt and Andy worked on, the Emmy-winning pop-science show Could You Survive The Movies?, Andy's Top Gun cameo, Fat Bear Week, Goro's pecs, a south-of-the-border Orson Welles experience, using AI to figure out the sperm whale phonetic alphabet, Larry the cat and Boris Johnson and The Higgins Boys & Gruber.

Comedian Todd Barry (@toddbarry) joins Matt, Andy and Jesse to talk about his new special Domestic Shorthair, an FDA ban of a citrus soda ingredient, ginger ale vs. ginger beer, the quackery of Dr. Idz, new images of an asteroid that just whizzed by Earth, Jesse's air force base food poisoning story, whether toxoplasmosis causes crazy cat lady syndrome and Jackson Galaxy's Cat Camp.