Pushing The Limits

De: Lisa Tamati
  • Resumen

  • "Pushing the Limits" - hosted by ex-professional ultra endurance athlete, author, integrative health practitioner and longevity expert, Lisa Tamati, is all about human optimization, longevity, high performance and being the very best that you can be. Lisa Interviews world leading doctors, scientists, researchers, elite athletes and high performers at the cutting edge of the longevity, anti-aging world. www.lisatamati.com
    © 2024
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Episodios
  • The Future Of Aging And Immunity With Dr. David Furman
    Oct 3 2024
    In this weeks episode of "Pushing the Limits" , Dr. David Furman, Director of the 1000 immunomes project, the world's largest longitudinal population-based study of immunology and aging at Stanford University and Associate Professor at the Buck Institute for Aging, Founder of Edifice Health and Cosmica Biosciences, discusses his extensive research in immunology, particularly focusing on the 1000 Immunomes Project, which aims to understand the immune system's role in aging. He emphasizes the importance of studying human biology over traditional animal models and introduces the concept of the Inflammation Age Clock as a new biomarker for aging. The discussion also covers the implications of systemic chronic inflammation in aging, the role of nutrition, and the potential for interventions to improve health span. Additionally, Dr. Furman shares insights into his work with NASA on accelerated aging in astronauts, highlighting the broader applications of his research in combating age-related diseases. Takeaways: Dr. Furman aims to have a massive impact on human health.The immune system plays a crucial role in aging.Human studies provide better insights than animal models.The Inflammation Age Clock is a new biomarker for aging.Chronic inflammation is a key factor in age-related diseases.Nutrition significantly affects inflammation and aging.Reliable biomarkers are needed for effective aging interventions.NASA's research on astronauts reveals accelerated aging in space.The convergence of technologies is revolutionizing health research.Future research will focus on protecting astronauts and advancing aging studies. Titles: System Chronic Inflammation: The Hidden Driver of Aging Nutrition and Inflammation: Key Factors in Health span About the 1000 immunomes Project: The Stanford 1000 Immunomes Project (KIP) is a collaborative ongoing study at Stanford University that aims to define the biological basis of aging and disease using state-of-the-art 'omics' platforms and advanced artificial intelligence (AI) methods. The main focus of 1KIP is to establish biomarkers for healthy versus sub-functional immune systems. They do this by identifying the interactions between genetic and environmental factors, which contribute to the observed heterogeneity of biological responses in human beings. To this end, 1000 individuals of different age groups (9-96 years old) were recruited between 2007-2017. Their blood samples were screened using multiple state-of-the-art technologies at a single facility, the Human Immune Monitoring Center (HIMC) to measure circulating proteins, cell types, cellular functions, whole-genome blood gene expression and subjects' haplotypes using deep sequencing technologies. The 1KIP dataset has enabled us for the first time to identify reliable biomarkers of aging and disease in a longitudinal population-based study of immunology and aging. 1KIP provides reference values for thousands of immune variables and identifies clusters of individuals sharing similar health versus disease immune profiles. BIO Dr. David Furman is an academic entrepreneur deeply committed to addressing intricate challenges within human biology, systems medicine, translational immunology, preventative healthcare, aging, and precision longevity. Holding positions as the Director of the Stanford 1000 Immunomes Project at the Stanford School of Medicine and as an Associate Professor and Director of the Bioinformatics and Data Science Core at the Buck Institute for Research on Aging, Dr. Furman leads research endeavors that leverage multi-scale biology ('omics') platforms and advanced AI/ML methodologies. He identifies biomarkers and integrative biological clocks essential for monitoring individual health statuses. Groundbreaking technologies originating from the Furman lab now facilitate the application of descriptive and mechanistic biomarkers to detect and combat accelerated aging and disease progression. With over 15 years of specialization in inflammation's role in aging mechanisms, Dr. Furman's expertise includes various domains, including neuroscience, cardiovascular health, metabolic diseases, and immune system function. Notably, in 2022, NASA's Human Research Program sought Dr. Furman's collaboration, leading to partnerships with SpaceX and Cornell University. Dr. Furman's entrepreneurial initiatives include the founding of the Inflammaging Institute, aimed at democratizing biological aging diagnosis, and the establishment of Stanford spin-off Edifice Health Inc., and Buck Institute spin-off Cosmica Biosciences Inc., both focused on innovative approaches to combat aging-related ailments and precision longevity interventions. Dr. Furman has published over 50 scientific articles in top-tier journals such as Cell, Nature Medicine, PNAS, The Lancet, and others, and is the inventor of over 25 patents. Personalised Health Optimisation Consulting with Lisa Tamati Lisa offers solution focused ...
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    1 h y 3 m
  • Precision Psychiatry & Holistic Mental Health With Dr. Mizyl Damayo
    Sep 26 2024
    In this insightful episode, we are joined by Dr. Mizyl Damayo, a holistic psychiatrist and founder of **Paradise Behavioral Health. Dr. Damayo specializes in precision psychiatry, an approach that goes beyond traditional psychiatric treatments to address the underlying causes of mental health disorders. She combines modern science with integrative, holistic therapies to deliver customized care tailored to each patient's unique needs. Key Topics Covered: * Precision Psychiatry: - What it is and why it's revolutionizing mental health treatment. *Nutrient Deficiencies and Toxicities: - How imbalances in essential vitamins, minerals, and other nutrients can contribute to mental health issues, and how correcting these imbalances leads to improved brain function. *Hormone Replacement Therapy (HRT): The critical role hormones play in mood regulation, anxiety, and depression, and why balancing hormones is essential for mental wellness. *Hyperbaric Oxygen Therapy (HBOT): - A deep dive into how HBOT supports brain function, helps repair neural damage, and promotes overall mental clarity and emotional balance. *Transcranial Magnetic Stimulation (TMS): - How TMS is offering new hope for treatment-resistant depression by using magnetic pulses to stimulate brain regions involved in mood regulation. *The Limitations of Traditional Drug Therapy: - Why relying solely on medications to treat psychiatric conditions often fails to address the root causes of mental health issues, leading to incomplete or temporary relief. Ailments Dr. Damayo Treats: Dr. Damayo works with a wide range of psychiatric and neurological conditions, including: Depression** (including treatment-resistant depression)Anxiety disordersBipolar disorderPost-Traumatic Stress Disorder (PTSD)Obsessive-Compulsive Disorder (OCD)Attention Deficit Hyperactivity Disorder (ADHD)Chronic fatigue and brain fogCognitive decline and memory issues Her precision psychiatry approach focuses on identifying the root causes of these disorders rather than just managing symptoms with medications. By uncovering nutrient deficiencies, toxicities (such as heavy metals), hormonal imbalances, and even neural damage, Dr. Damayo's approach offers a **whole-person** treatment plan that leads to more sustained mental and physical health. Why the Traditional Drug Approach Isn't Enough: For decades, the standard treatment for mental health disorders has been primarily **pharmaceutical drugs**. While these medications can provide symptom relief, they often fail to address the underlying causes of mental health conditions. Patients may experience side effects, dependence, or only partial relief. Dr. Damayo believes that while drugs can be part of the treatment, they should not be the only approach. By focusing on the root causes—such as nutrient imbalances, toxic buildup, and hormonal fluctuations—Dr. Damayo is able to offer a more comprehensive and effective solution. Her practice also emphasizes natural healing methods, such as hyperbaric oxygen therapy and ranscranial magnetic stimulation, which can significantly enhance brain health and recovery. Advanced Therapies Explained: *Hyperbaric Oxygen Therapy (HBOT): - By delivering oxygen under high pressure, HBOT increases oxygen levels in the brain, which helps heal damaged tissues, reduce inflammation, and promote neurogenesis (the growth of new brain cells). This therapy has been particularly beneficial for patients with cognitive issues, brain fog, and trauma-related conditions. * Transcranial Magnetic Stimulation (TMS): - TMS is a non-invasive, FDA-approved treatment that stimulates specific areas of the brain using magnetic pulses. It has shown remarkable success in treating depression, especially in cases where antidepressants have failed. TMS is also being explored for conditions like anxiety, PTSD, and OCD. Dr. Damayo's Unique Approach: Dr. Damayo's **precision psychiatry** integrates lab testing to identify deficiencies, environmental toxins, and other imbalances that could be contributing to mental health issues. Her personalized treatment plans may include **nutrient supplementation**, **detoxification protocols**, **hormone replacement**, and advanced therapies like HBOT and TMS. This **holistic model** looks at both the **mental and physical** aspects of health, understanding that the two are deeply interconnected. Mental health is complex, and there's no one-size-fits-all solution. Dr. Mizyl Damayo's innovative approach offers hope to those who have struggled with traditional treatments by focusing on the root causes of psychiatric conditions. Her **holistic and personalized** methods are helping patients achieve not just symptom relief, but true healing and long-term wellness. For more information about Dr. Damayo's practice and her unique precision psychiatry approach, visit her website at [Paradise Behavioral Health](https://www.paradisebehavioral.com/drdamayo/). BIO Dr. Damayo is ...
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    1 h y 10 m
  • Healing Brains: How Omega-3s Can Prevent And Repair The Brain Dr. Michael Lewis
    Sep 19 2024
    In this episode, we have the privilege of speaking with Dr. Michael Lewis, renowned expert in brain health and traumatic brain injury (TBI), and author of the groundbreaking book, When Brains Collide. Dr. Lewis is the founder of the Brain Health Education and Research Institute and BrainCARE. With a military background and extensive experience in traumatic brain injuries, Dr. Lewis has dedicated his career to exploring how omega-3 fish oils can play a vital role in preventing and recovering from concussions, TBI, stroke, and neurodegenerative diseases. Key Discussion Points 1. The Role of Omega-3 Fish Oils in Brain Health Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA), the primary omega-3 fatty acids found in fish oil, are crucial for maintaining brain structure and function. Omega-3s are anti-inflammatory and neuroprotective, making them vital in protecting the brain from injury and supporting recovery. 2. High-Dose Omega-3 Fish Oil for Concussions and Traumatic Brain Injury (TBI) Dr. Lewis emphasizes how high-dose fish oil can help mitigate damage following a concussion or TBI. Dosing Protocols: In acute brain injury cases, Dr. Lewis recommends significantly higher doses of fish oil (e.g., up to 3-9 grams of combined DHA and EPA per day) to reduce inflammation, promote healing, and restore brain cell membrane integrity. Case studies demonstrate remarkable improvements in TBI patients, including quicker recovery times, reduced brain fog, and restored cognitive function. 3. Fish Oils for Neurodegeneration and Stroke Prevention Regular intake of omega-3s is shown to be effective in reducing the risk of neurodegenerative diseases like Alzheimer's and Parkinson's. Omega-3s help prevent stroke by reducing blood clot formation, improving vascular health, and lowering inflammation in brain tissues. Dr. Lewis advocates for omega-3s as part of a preventive strategy, particularly for aging individuals at higher risk of neurodegenerative conditions. 4. Using Omega-3s as Preventive Medicine Consistent omega-3 supplementation is not just for recovery—it's crucial for maintaining optimal brain health. Athletes, military personnel, and individuals at risk for head trauma should use omega-3s proactively to strengthen their brain's resilience to injury. Preventative Dosing: Dr. Lewis suggests a daily intake of at least 2-3 grams of DHA and EPA combined for ongoing brain health and injury prevention. 5. How to Choose a High-Quality Fish Oil Dr. Lewis explains the criteria for identifying a high-quality fish oil supplement: Purity: Free from contaminants like heavy metals and toxins. Potency: Look for a high concentration of DHA and EPA. Stability: Avoid fish oils that oxidize easily, as rancid oils can be harmful. Sourcing: Prefer fish oils sourced from wild-caught, sustainably harvested fish. Importance of third-party testing to ensure the product is safe and effective. 6. Personal Stories and Case Studies Dr. Lewis shares inspiring stories of patients and athletes who have successfully used omega-3 therapy to recover from brain injuries. Examples include a football player who recovered from multiple concussions and a stroke survivor who regained cognitive function with high-dose omega-3 supplementation. 7. How to Use Omega-3s After Brain Injury Immediate supplementation following a brain injury can make a significant difference in recovery outcomes. The sooner omega-3s are introduced post-injury, the better. Dr. Lewis provides insight into the timing and administration of omega-3 supplements during the acute phase of brain injury treatment. Recommended Resources: Dr. Michael Lewis's Website: Brain Health Education and Research Institute: http://www.brainhealtheducation.org/ BrainCARE: BrainCARE Center When Brains Collide Book Join us for this enlightening discussion on the powerful benefits of omega-3 fish oils for brain protection, recovery, and overall health. Dr. Michael Lewis's pioneering work is transforming how we approach brain injuries and neurodegeneration, highlighting the critical role that nutrition and supplementation play in maintaining cognitive vitality. Tune in to learn how you can harness the power of omega-3s for your brain health and optimize your recovery from injury or disease. BIO Michael Lewis, MD, MPH, MBA, FACPM, FACN, is a proven leader and expert in the treatment and management of concussions and brain injuries. He also applies his holistic approach to Men's Health and outpatient orthopedics. Upon retiring as a Colonel in the U.S. Army, he founded the nonprofit Brain Health Education and Research Institute and entered private practice focusing on helping patients with chronic concussion issues. His pioneering work in the military and since has helped thousands of people around the world and he is regularly featured in the media, radio, podcasts, webinars, scientific conferences, and television. A lifelong athlete, Dr. Lewis serves on the Pop Warner Youth...
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    1 h y 35 m

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