In this episode, we are joined by Dr. Francisco González-Lima to delve into the metabolic mechanisms that drive brain aging and cognitive decline.

He begins by outlining how reductions in cytochrome oxidase activity, disruptions in oxidative phosphorylation, and the accumulation of mitochondrial mutations progressively impair neuronal energy metabolism. These metabolic deficits, he explains, often emerge long before the structural abnormalities associated with Alzheimer's disease.

Building on this foundation, the conversation examines how reactive oxygen species, mitochondrial inefficiency, and altered cortical oxygen utilization contribute to diminished cognitive resilience over time. Dr. González-Lima highlights why these metabolic disturbances provide a more coherent explanation for geriatric dementia than traditional protein-centric models.

The discussion then shifts to emerging therapeutic strategies. Dr. González-Lima reviews evidence for low-dose methylene blue and 1064 nm transcranial photobiomodulation, both of which appear to enhance mitochondrial respiration and support prefrontal function by directly targeting cytochrome oxidase activity.

He concludes by emphasizing the need for metabolism-focused interventions, improved cerebral perfusion, and more precise energy-based frameworks to guide the future of brain-aging therapeutics.

We are joined by behavioral epidemiologist Dr. Kate Wolin to unpack why so many health interventions collapse outside the lab—and what actually drives lasting change in the real world.

From frictionless habit design and daily self-monitoring to movement, sleep, and the muscle-preserving realities of GLP-1s, she reveals the behavioral strategies that truly move the needle on long-term metabolic and overall health.

Watch the full episode to learn how evidence-based behavior science can transform your healthspan.

Learn more about Dr. Kate Wolin:

https://drkatewolin.com/

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Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0

Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com

In this episode, we are joined by Dr. Jennifer Elisseeff to discuss the evolving field of tissue engineering and its applications in regenerative medicine.

She explains the shift from using stem cells to focusing on immune cells for tissue repair, the challenges of regenerating cartilage, and the importance of vascularity in tissue health.

The discussion also covers the impact of aging on tissue repair, the role of senescent cells, and the future of personalized medicine in tissue engineering.

Dr. Elisseeff emphasizes the need for innovative approaches and the integration of immunotherapies to enhance tissue repair processes.

Learn more about Dr. Jennifer Elisseeff:

https://www.bme.jhu.edu/people/faculty/jennifer-h-elisseeff/

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Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0

Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com

Dr. Heidi Tissenbaum, a molecular geneticist at UMass Chan Medical School, joins Dr. Buck Joffrey to explore what C. elegans worms have revealed about the biology of aging.

She explains how these simple organisms helped uncover key longevity pathways—like insulin/IGF-1 signaling and sirtuins—that also exist in humans.

The conversation dives into the balance between stress and resilience, the role of IGF-1 in muscle health and lifespan, and why she believes true longevity breakthroughs will require understanding how the body's systems communicate as a whole.

Learn more about Dr. Heidi Tissenbaum:

https://profiles.umassmed.edu/display/133231

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Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0

Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com

This week, Professor Jan Vijg joins us to discuss the intricate relationship between DNA mutations, epigenetic drift, and aging.

He explains the differences between mutations and epigenetic changes, the role of environmental factors, and the potential for reversing epigenetic changes.

The conversation also touches on the implications of somatic mutations and the future of longevity research, particularly in relation to DNA repair mechanisms.

Learn more about Professor Jan Vijg:

https://einsteinmed.edu/faculty/11318/jan-vijg

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Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0

Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com

In this episode, we are joined by Dr. Keith Diaz to discuss the significant health risks associated with prolonged sitting, likening it to smoking in terms of its dangers.

He emphasizes the importance of regular movement, introducing the concept of 'movement snacks'—short bursts of activity that can mitigate the negative effects of sitting.

We also cover the physiological mechanisms behind how movement affects blood sugar levels and inflammation, as well as insights from blue zones where people naturally incorporate more movement into their daily lives.

Dr. Diaz advocates for personalized movement recommendations to help individuals improve their health outcomes.

Learn more about Dr. Keith Diaz:

https://www.columbiacardiology.org/profile/keith-diaz-phd

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Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0

Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com

In this episode, we are joined by Dr. Mitchell Roslin to discuss the complexities of obesity.

We explore the role of GLP-1 medications in weight management, the evolution of bariatric surgery, and the innovative SIPS procedure.

Dr. Roslin emphasizes that obesity is not merely a result of poor lifestyle choices but involves intricate biological and hormonal mechanisms.

He also highlights the importance of functional assessments in determining appropriate treatment for obesity, advocating for a more systematic approach to obesity management.

Learn more about Dr. Mitchell Roslin: https://faculty.medicine.hofstra.edu/4990-mitchell-roslin

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Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0

Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com

In this episode, Dr. Karl Pfleger joins us to discuss the evolving landscape of longevity research and investment.

He emphasizes the shift from disease-specific approaches to understanding aging as a multifaceted process that underpins many chronic diseases.

Dr. Pfleger outlines his investment strategies in the aging biotech sector, highlighting the importance of addressing various sub-pathologies of aging.

He also discusses the concept of longevity escape velocity, the challenges of proving longevity therapies, and the role of aging clocks in research.

Learn more about Dr. Karl Pfleger:

https://x.com/karlpfleger?lang=en

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Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0

Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com