• 74: Bead-Based Assays: The Power of High-Throughput Screening w/ Sebastian Giehring - Part 2
    Jul 25 2024

    Dive into the transformative world of bead-based assays with Sebastian Giehring, CEO and founder of PAIA Biotech, where high-throughput screening meets cutting-edge biotechnological advancements.

    Join us as we chat with Sebastian, a seasoned scientist and entrepreneur who has revolutionized the workflow of high-throughput screening of titer, glycosylation, and aggregation with innovative bead-based assays.

    Key Takeaways:

    1. Streamlined Workflow: Learn how a simplified sample prep can enhance efficiency and accuracy in glycosylation and aggregation screenings.
    2. Optimized Experiment Design: Discover the critical do's and don'ts in designing robust experiments that yield meaningful results.
    3. Future of Screening: Explore how AI and machine learning are set to revolutionize the biotechnological landscape, driving better drug development and process optimization.

    Tune in to uncover how these insights can transform your lab's capabilities and drive groundbreaking discoveries!

    Connect with Sebastian Giehring:

    LinkedIn: https://www.linkedin.com/in/sebastian-giehring-6ba1992

    PAIA Biotech: https://www.paiabio.com

    Next Steps:

    Book a free assessment to help you get started with the design of your next experiment at https://bruehlmann-consulting.com

    Develop biologics better, faster, at a fraction of the cost with our Fractional CTO services. Curious? DM us at hello@bruehlmann-consulting.com

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    17 m
  • 73: Bead-Based Assays: The Power of High-Throughput Screening w/ Sebastian Giehring - Part 1
    Jul 23 2024

    Ready to revolutionize your lab work? Join us as we dive deep into bead-based assays with Sebastian Giehring, CEO and founder of PAIA Biotech.

    Discover how these tiny beads are making a massive impact on biotech research and development — for titer, glycan, and aggreation screening — and how this developability screening platform can enhance your antibody discovery, antibody engineering and lead optimization.

    In this episode, you’ll learn:

    1. Speed and Simplicity: How bead-based assays offer unmatched throughput and ease of use, allowing you to analyze hundreds of samples in just a few steps.
    2. Versatile Applications: The diverse applications of bead-based assays in cell development, bioprocessing, and antibody discovery, helping streamline workflows and enhance innovation.
    3. Early Screening Advantages: The benefits of bead-based assays in early-stage process development, enabling quick decision-making with less detailed but rapid results.

    Tune in to uncover how these assays can transform your biotech research and push the boundaries of what's possible!

    Connect with Sebastian Giehring:

    LinkedIn: https://www.linkedin.com/in/sebastian-giehring-6ba1992

    PAIA Biotech: https://www.paiabio.com

    Next Steps:

    Book a free assessment to help you get started with the design of your next experiment at https://bruehlmann-consulting.com

    Develop biologics better, faster, at a fraction of the cost with our Fractional CTO services. Curious? DM us at hello@bruehlmann-consulting.com

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    19 m
  • 72: Effective Outsourcing: How Small Biotech Companies Can Thrive w/ Mark Melville - Part 2
    Jul 18 2024

    How do small biotech companies make strategic decisions with limited resources? This episode dives deep into the art of prioritization and outsourcing to achieve success.

    Join us as we speak with Mark Melville, Vice President of CMC, Biologics at Cullinan Therapeutics, a seasoned biotech scientist with years of experience in both large and small biotech companies. Mark shares his invaluable insights on navigating the complexities of bioprocess development and outsourcing.

    In this episode, we explore:

    1. Discover the secrets to prioritizing projects for maximum impact
    2. Leverage outsourcing for flexibility and expertise
    3. Learn to build strong relationships with external vendors to ensure top-notch quality and regulatory compliance.

    Connect with Mark Melville:

    LinkedIn: https://www.linkedin.com/in/mark-melville-a9a43b2

    Next Steps:

    Wondering how to develop biologics with peace of mind? Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessment

    Develop biologics better, faster, at a fraction of the cost with our Fractional CTO services. Curious? DM us at https://bruehlmann-consulting.com

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    22 m
  • 71: Effective Outsourcing: How Small Biotech Companies Can Thrive w/ Mark Melville - Part 1
    Jul 16 2024

    Are you navigating the complex world of bioprocess CMC development and manufacturing in a small biotech company?

    Our latest episode is a must-listen! Join us as we sit down with Mark Melville, Vice President of CMC, Biologics at Cullinan Therapeutics, who shares invaluable insights on overcoming the unique challenges faced by small biotech firms.

    In this episode, we explore:

    1. The critical communication strategies needed for successful outsourcing to CDMOs.
    2. How small biotechs can leverage their agility to make fast, impactful decisions.
    3. The surprising benefits of wearing multiple hats and fostering cross-functional expertise.

    Tune in to discover how mastering these areas can help your small biotech thrive and stay ahead in a competitive market.

    Don't miss this opportunity to gain practical advice and turn your challenges into advantages!

    Connect with Mark Melville:

    LinkedIn: https://www.linkedin.com/in/mark-melville-a9a43b2

    Next Steps:

    Wondering how to develop biologics with peace of mind? Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessment

    Develop biologics better, faster, at a fraction of the cost with our Fractional CTO services. Curious? DM us at https://bruehlmann-consulting.com

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    19 m
  • 70: Glycoanalytics Explained: Analysing and Designing Better Biopharmaceutical Drugs w/ Róisín O’Flaherty - Part 2
    Jul 11 2024

    In this insightful episode, we explore the cutting-edge field of glycoengineering and its transformative impact on biopharmaceutical drug design. Join us as we chat with Róisín O’Flaherty, Assistant Professor in the Department of Chemistry at Maynooth University, to uncover the nuances of chemoenzymatic glycogen engineering and its potential to revolutionize therapeutics.

    Key Takeaways:

    1. Understanding Glycoengineering: Discover the three main approaches—genetic, metabolomic, and chemoenzymatic—for modifying glycosylation and enhancing drug properties.
    2. Real-World Applications: Learn how industry giants are leveraging glycoengineering to innovate cancer treatments and other therapies.
    3. Future of Glycoanalytics: Explore how AI and machine learning are poised to further advance the precision and efficiency of glycoengineering.

    Don't miss this deep dive into how glycoanalytics is paving the way for more effective and personalized biopharmaceutical drugs. Tune in to understand the future of drug design and the exciting possibilities it holds.

    Connect with Róisín O’Flaherty:

    LinkedIn: https://www.linkedin.com/in/roisin-o-flaherty-a67a2b8a

    Twitter: https://x.com/irishglycogirl

    Next Steps:

    Book a free assessment to help you get started with glycoanalytics and glycoengineering at https://bruehlmann-consulting.com

    Develop biologics better, faster, at a fraction of the cost with our Fractional CTO services. Curious? DM us at hello@bruehlmann-consulting.com

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    16 m
  • 69: Glycoanalytics Explained: Analysing and Designing Better Biopharmaceutical Drugs w/ Róisín O’Flaherty - Part 1
    Jul 9 2024

    Uncover the hidden science behind creating safer, more effective biological drugs! Dive into glycoanalytics and glycoengineering, the secret weapons revolutionizing biopharma.

    Join us as we talk with Róisín O’Flaherty, Assistant Professor in the Department of Chemistry at Maynooth University, who breaks down the complexities of glycosylation and its pivotal role in drug development.

    Key Takeaways:

    1. Critical Quality Attributes: Understand how glycans influence the function and structure of biopharmaceutical products, enhancing their efficacy and safety.
    2. Analytical Techniques: Learn about the three major approaches—native glycoprotein analysis, glycopeptide analysis, and released glycan analysis—each providing unique insights into glycosylation.
    3. Future Trends: Discover how automation, AI, and advanced mass spectrometry are revolutionizing glycoanalytics, making it more accessible and precise.

    Tune in to explore how glycoanalytics is driving the next generation of safer, more effective biopharmaceuticals!

    Connect with Róisín O’Flaherty:

    LinkedIn: https://www.linkedin.com/in/roisin-o-flaherty-a67a2b8a

    Twitter: https://x.com/irishglycogirl

    Next Steps:

    Book a free assessment to help you get started with glycoanalytics and glycoengineering at https://bruehlmann-consulting.com

    Develop biologics better, faster, at a fraction of the cost with our Fractional CTO services. Curious? DM us at hello@bruehlmann-consulting.com

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    18 m
  • 68: How Process Mapping Transforms Knowledge Management in Biotech w/ Irwin Hirsh - Part 2
    Jul 4 2024

    Join us as we explore the pivotal role of process mapping in biotech knowledge management. Our guest, Irwin Hirsh, a seasoned biotech consultant concentrating on enhancing business efficiency and effectiveness, shares invaluable insights into leveraging technology to streamline operations.

    Key Insights:

    1. Identifying Critical Process Knowledge: Learn strategies to identify and manage vital process knowledge essential for optimal performance.
    2. Transitioning from Implicit to Explicit Knowledge: Discover why converting hidden, tribal wisdom into structured, accessible information is crucial for scalability and continuity.
    3. Harnessing Digital Tools: Explore effective approaches to digital transformation, ensuring seamless integration and collaboration across teams and time zones.

    Join us as Irwin uncovers actionable steps to enhance efficiency and innovation in biotech through strategic process mapping.

    Connect with Irwin Hirsh:

    LinkedIn: https://www.linkedin.com/in/ishirsh

    Q-Specialists AB: https://www.qspecialists.com

    Next Steps:

    Wondering how to develop biologics and cell & gene therapies with peace of mind? Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessment

    Develop biologics better, faster, at a fraction of the cost with our Fractional CTO services. Curious? DM us at https://bruehlmann-consulting.com

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    29 m
  • 67: How Process Mapping Transforms Knowledge Management in Biotech w/ Irwin Hirsh - Part 1
    Jul 2 2024

    Want to turn your biotech chaos into streamlined success? Learn from expert Irwin Hirsh, a seasoned biotech consultant concentrating on enhancing business efficiency and effectiveness, on how process mapping can transform your knowledge management and elevate your business performance.

    Key Takeaways:

    1. Eliminate Scope Creep: Learn how to maintain focus in projects despite shifts and changes, improving productivity and reducing frustration.
    2. Bridge Experience Gaps: Understand how process mapping creates a common language, enabling seamless knowledge transfer between seasoned experts and newcomers.
    3. Enhance Systematic Approach: Discover the power of standardization and continuous improvement to boost overall business performance.

    Tune in to uncover practical strategies that can transform your knowledge management practices and drive your biotech endeavors to new heights.

    Connect with Irwin Hirsh:

    LinkedIn: https://www.linkedin.com/in/ishirsh

    Q-Specialists AB: https://www.qspecialists.com

    Next Steps:

    Wondering how to develop biologics and cell & gene therapies with peace of mind? Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessment

    Develop biologics better, faster, at a fraction of the cost with our Fractional CTO services. Curious? DM us at https://bruehlmann-consulting.com

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    14 m