TTP is a life-threatening rare blood disorder requiring rapid diagnosis and treatment. Dr Eng Soo Yap and patient advocate, Ms Lisa Foster, help us understand more about the two main types of TTP, immune-mediated TTP (iTTP) and congenital TTP (cTTP), and the overall impact it has on the patient.

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Despite extensive research in this area, TTP diagnosis continues to be a challenging affair for clinicians. Dr Eng Soo Yap helps us understand more about the current approach to diagnosis, the importance of ADAMTS13 testing, and the challenges associated with distinguishing between iTTP and cTTP. 

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Dr Eng Soo Yap helps us understand more about the role of therapeutic plasma exchange (TPE) in treating iTTP and cTTP, and some of the challenges associated with the current treatment paradigm. He also shares insights on promising therapeutics such as TAK-755 that are currently under investigation. 

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In the last episode of this series on TTP, Dr Eng Soo Yap shares some of his clinical experiences with the diagnosis and management of immune-mediated and congenital forms of TTP.

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Prof. Rima Nabbout and patient advocate, Ms Lisa Foster, tell us more about DS and LGS, rare epileptic disorders that are associated with high morbidity and mortality, and the significant impact they have on patients and their families.

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Prof. Rima Nabbout deep dives into the aetiology of DS, including genetic alterations such as SCN1A mutations. She also tells us about diagnosing and treating these conditions, in addition to some of the challenges she encounters in clinical practice.

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In this episode, Prof. Rima Nabbout describes the clinical presentation, and diagnosis of LGS. She also walks us through some of the available treatment modalities and the limitations associated with treating patients with this disease.

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In the last episode of this series on DS and LGS, Prof. Rima Nabbout shares details on several clinical cases involving DS and LGS and outlines her thought process when addressing some of the challenges associated with the diagnosis and management of these conditions in real-world settings.

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