Welcome to the 20th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.

This episode features a discussion with the final author Dr Jun Li of the Brain article entitled: PAK2 is necessary for myelination in the peripheral nervous system

How are peripheral nerve cells myelinated and what proteins are invoved? Is there a difference between PAK1 and PAK2? Listen for this and more in this exciting episode.

Check out the full article on the Brain website: https://doi.org/10.1093/brain/awad413

This episode was co-hosted by Andreas Thermistocleous and David Michael, edited and produced by David and Xin You Tai, co-produced by Antonia Johnston, original music by Ammar Al-Chalabi.

Welcome to the 18th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.

This episode features a discussion with first author author Dr Stefanie Grabrucker of the Brain article entitled: Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesis

How does lifestyle and the environment affect cognition in Alzheimer's disease via the gut and what can we do about it? Listen for this and more in this exciting episode.

Check out the full article on the Brain website: https://doi.org/10.1093/brain/awad303

This episode was co-hosted by Chaitra Sathyaprakash and Adam Handel, edited and produced by Chaitra and Xin You Tai, co-produced by Antonia Johnston, original music by Ammar Al-Chalabi.

Welcome to the 17th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.

This episode features a discussion with senior author Dr Bénédicte Ballanger of the Brain article entitled: Noradrenergic alterations in Parkinson’s disease: a combined 11C-yohimbine PET/neuromelanin MRI study

Can this multi-modal study examining the role of Noradrenaline in Parkinson's disease offer insight into important neurotrasmitter pathophysiology and provide the basis for a non-dopamine therapeutic strategy?

Check out the full article on the Brain website: https://doi.org/10.1093/brain/awad338

This episode was co-hosted by Andreas Themistocleous and Michael David, edited and produced by Michael David and Xin You Tai, co-produced by Antonia Johnston, original music by Ammar Al-Chalabi.

Welcome to the 16th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. 

We are very excited to feature a January issue Brain article, where we speak with senior author Dr Lasse M Giil entitled:  Impaired glucose utilization in the brain of patients with delirium following hip fracture

Delirium is a common condition with significant impact on patient outcome. This episode discussed potential intrinsic brain mechanisms that may underly delirium. The team explores the evidence that delirium is more than just a systemic process that extends into the brain but may involve pathophysiological alterations of brain function. Listen to how this may change clinical practice. 

Check out the full article on the Brain website: https://doi.org/10.1093/brain/awad296

This episode was co-hosted by Andreas Themistocleous and Michael David,  edited and produced by Michael David and Xin You Tai, co-produced by Antonia Johnston, original music by Ammar Al-Chalabi.

Welcome to the 15th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. 

We are very excited to feature our first article from Brain Communications, where we speak with first author Dr Kiel Telesford of the article entitled: Neuron-binding antibody responses are associated with Black ethnicity in multiple sclerosis during natalizumab treatment

This episode discussed racial differences in antibody response to natalizumab treatment for individuals of black ethnicity with multiple sclerosis. Further, they consider potential mechanisms which may underly differences and the implications on treatment. 

Check out the full article on the Brain Communications website: https://doi.org/10.1093/braincomms/fcad218

This episode was co-hosted by Andreas Themistocleous and Debra Ehrlich,  edited and produced by Michael David and Xin You Tai, co-produced by Antonia Johnston, original music by Ammar Al-Chalabi.

Welcome to the 14th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. 

In this episode we speak with Fu-Chin Liu, senior author of the article entitled: Speech- and language-linked FOXP2 mutation targets protein motors in striatal neurons. 

This article explores a potential genetic basis for disordered speech by a mutation in the transcription factor FOXP2. This was discovered in KE family members with speech disturbances was a landmark example of the genetic control of vocal communication in humans. The author and colleagues examine an animal model of the KE family FOXP2R553H mutation to explore cellular pathomechanisms involving intracellular dynein-dynactin ‘protein motors’ in the striatum.

Check out the full article on the Brain website: https://doi.org/10.1093/brain/awad090

We also hear from our new podcast host, Dr Chaitra Sathyaprakash, who is a post-doctoral fellow at National Institute of Neuroscience, Kodaira, Tokyo, Japan- welcome to the team!

This episode was co-hosted by Adam Handel and Chaitra Sathyaprakash,  edited and produced by Xin You Tai, co-produced by Antonia Johnston, original music by Ammar Al-Chalabi.

Welcome to the 13th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. 

In this episode we speak with Josef Parvizi, senior author of the article entitled: Multisite thalamic recordings to characterize seizure propagation in the human brain

This article explores the role of the thalamus in seizure propagation and how multi-site intracranial electrode recordings identify new and unexpected findings regarding which thalamic nuclei may have the earliest involvement  in seizure propagation.

Check out the full article on the Brain website: https://doi.org/10.1093/brain/awad121

This episode was co-hosted by Debra Ehrlich and Andreas Thermistocleous, edited and produced by Xin You Tai and David Michael, co-produced by Antonia Johnston, original music by Ammar Al-Chalabi.

Welcome to the 12th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. 

In this episode we speak with Nico Melzer, senior author of the article entitled: A genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies

This article explores expanding entity of GAD-65 associated neurological syndromes, the exciting role of T-cells and potential therapeutic avenues that these findings may bring. 

Check out the full article on the Brain website: https://doi.org/10.1093/brain/awac119

This episode was co-hosted by Adam Handel and Darshan Pandya , edited and produced by Adam Handel and Xin You Tai; co-produced by Antonia Johnston; original music by Ammar Al-Chalabi.