In this first deep dive, Glenda Gray unpacks what antimicrobial resistance means for clinicians beyond infectious diseases, and why it is already a leading cause of death globally. She explores the disproportionate burden in low- and middle-income countries, the devastating impact on neonates and infants, and the critical role of diagnostics, vaccines, and infection prevention.

Timestamps:
00:00 – Introduction

00:45 – What is AMR?

01:32 – Burden on LMICs

02:57 – Impact on infants

04:05 – Diagnostic gaps

05:10 – Comprehensive strategies

Glenda Gray joins the EMJ Podcast for a quickfire discussion on antimicrobial resistance and child health. From antibiotic misconceptions to equitable access and stewardship, she shares sharp insights into why AMR is a defining global health challenge for children today.

Description: The final deep dive episode looks ahead: stem cells, tissue transplantation, fertility preservation in cancer care, and the policy challenges limiting access to advanced male infertility treatment. A future-facing discussion on cures and equity.

Timestamps:
00:00 – Introduction

01:02 – Stem cells

04:08 – Fertility preservation

05:04 – Access and cost

07:04 – Pricing variability

08:20 – What's next?

Description: In this second deep dive, Schlegel explains how microTESE transformed sperm retrieval. Learn how microsurgical precision improves outcomes, preserves testicular tissue, reduces pain, and why multidisciplinary collaboration drives high pregnancy rates.

Timestamps:
00:00 – Introduction

01:06 – Why the microscope?

03:09 – MicroTESE advantages

04:11 – Success rates

06:29 – Postoperative care

08:04 – Multidisciplinary approaches

Description: In this first deep dive, Peter N. Schlegel joins host Catherine Glass to unpack non-obstructive azoospermia. Explore genetic discoveries, hormonal optimisation, age-related factors, and practical strategies that maximise sperm retrieval and conception potential.

Timestamps:
00:00 – Introduction

01:13 – Non-obstructive azoospermia

02:01 – Genetics of infertility

04:01 – Aromatase inhibitors

06:05 – Sperm quality

07:27 – Multiple semen samples

10:27 – Infertility globally

In this rapid-fire episode, Peter N. Schlegel answers key questions about male infertility, from what drives success in microTESE to the role of genetics, hormones, and surgical skill. A concise introduction to the science shaping modern men's reproductive care.

Bairey Merz discusses the latest directions in microvascular and endothelial research, including links to heart failure with preserved ejection fraction, integration of adverse pregnancy outcomes and autoimmune disease into models, and promising technological advances.

Timestamps:

00:53 – Directions of the WISE programme

01:47 – Preserved ejection fraction

04:51 – Adverse outcomes of microvascular disease

08:42 – Technology improving outcomes