Shaping the field of cardiovascular medicine, emerging technologies have the potential to transform the treatment of vascular disease. Explore the latest advancements in cardiology with Jonathan and Nicholas Leeper, Professor of Surgery, Chief of Vascular Medicine, and Director of Vascular Research at Stanford University, California, USA.

Timestamps:

(00:00)-Introduction

(02:37)-Nicholas’s journey into cardiovascular medicine

(04:40)-Exciting advancements in cardiovascular research

(07:41)-Impact of COVID-19 on clinical practice and the fear of predatory journals

(12:13)-‘Bench-to-bedside' approach

(15:50)-Bitterroot Bio and Forty Seven Inc.

(22:53)-Initiatives Nicholas is involved in that are aiding cardiovascular care

(27:22)-The future of cardiovascular medicine

(30:45)-Biological similarity between cancer and cardiovascular disease

(34:42)-Nicholas’s three magic wishes

Discover the remarkable progress made in heart failure therapies with Jonathan and Haider Warraich, Director of the Heart Failure Program at VA Boston Healthcare System, Massachusetts, USA. They also discuss the intricacies of heart transplantation and end-of-life care.

Use the following timestamps to navigate the episode:

(00:00)-Introduction

(03:28)-Warraich’s journey into cardiology

(06:15)-Recent advances in heart failure therapies

(11:15)-What is the median survival from diagnosis of heart failure?

(14:45)-The current state of heart transplantation

(20:20)-Warraich’s experience in regulatory medicine

(24:33)-Warraich’s book: ‘Modern Death, How Medicine Changed the End of Life’

(33:45)-Warraich’s s book: ‘State of the Heart’

(40:12)-Warraich’s most recent book: ‘The Song of Our Scars: The Untold Story of Pain’

(46:13)-Warraich’s three wishes for healthcare

Jonathan and Maria Eugenia Inda, Pew Postdoctoral Fellow at MIT Synthetic Biology Center in Cambridge, Massachusetts, discuss the latest developments in microbiome research and their potential applications in personalised health, as well as the fascinating world of agar art.

Timestamps:

(00:00)-Introduction

(02:57)-Agar art

(06:03)-Art influencing the scientific mind

(07:40)-Intestinal biosensors

(12:30)-Implications for healthcare professionals

(19:35)-Next steps for this technology

(23:25)-Synthetic biology

(26:23)-The importance of developing communication skills

(30:45)-Maria’s three wishes for healthcare

Jonathan Weitzman, professor of genetics at the Université Paris Cité in France, joins Jonathan Sackier to discuss the role of epigenetic events in cellular differentiation programmes, as well as his own podcast, ‘The Lonely Pipette’.

Use the following timestamps to navigate this episode:

(00:00)-Introduction

(02:49)-Specialising in epigenetics

(05:45)-Helping young scientists navigate their careers

(11:58)-Back to basics: epigenetics

(19:21)-The emergence of ‘form’

(22:02)-Cell reprogramming

(23:26)-The Centre for Epigenetics and Cell Fate

(24:28)-Genetics in 30 seconds

(29:30)-Intracellular hijackers

(35:45)-Who am I?

(41:20)-Jonathan’s three wishes

Jonathan and Vindana Chibabhai, Associate Professor in the Department of Clinical Microbiology and Infectious Diseases at the University of the Witwatersrand, Johannesburg, South Africa, discuss novel tools for pathogen surveillance, and the future of microbiology.

Timestamps:

(00:00)-Introduction

(03:20)-Podcast host to podcast host

(04:50)-Vindana’s journey into microbiology

(06:48)-Antibiotic resistance

(10:38)-Antibiotic use and food consumption

(12:31)-What can we do about antibiotic resistance?

(14:34)-Pathogen surveillance

(16:58)-HIV in sub-Saharan Africa

(20:36)-Accepting HIV treatment

(22:22)-Vindana’s current PhD work

(24:10)-Microbe Mail podcast

(26:56)-International infectious diseases

(31:31)-Preventing the spread of diseases globally

(34:45)-Future of microbiology research

(36:58)-Three wishes for the future of healthcare

Jonathan and Peter Reynolds, Consultant Neonatologist and Paediatrician based at Ashford and St. Peter's Hospital, Chertsey, UK, discuss the importance of building relationships with the families of premature babies and emerging trends and advances in neonatal care.

Please use the following timestamps to navigate the episode:

(00:00)-Introduction

(02:45)-Peter’s journey from GP to paediatrics

(05:22)-mOm incubator trial

(09:28)-The DOLFIN study

(15:01)-Feeding premature babies

(17:05)-Surfactant delivery and guideline development

(21:30)-Nasal High Flow

(26:30)-Making the delivery room ‘parent friendly’

(31:20)-IGF-1 supplements for neonates

(34:34)-Inspiration Healthcare

(40:49)-Emerging trends in neonatal care

(48:09)-Peter’s 3 wishes for healthcare