Byrne discusses Dova's recent Late Breaker at the United European Gastroenterology (UEG) Week 2025, where AI re-analysis uncovered treatment effects missed by human readers. He explains how AI may soon become integral to clinical trial design, regulatory review, and drug approval, while predicting how AI-human partnerships will define the future of gastroenterology.

Timestamps:
01:05 – AI in the TITRATE trial
03:18 – Validating clinical endpoints
04:16 – AI and human readers
16:53 – The next frontier in gastrointestinal AI

Bias, privacy, and ethics take centre stage as Byrne discusses how to build trustworthy AI systems. From data transparency to global access, he shares practical steps to ensure equitable innovation and reflects on the fears clinicians express about integrating AI in their daily workflow.

Timestamps:
01:09 – Addressing bias and inequity
03:10 – Data privacy and regulation
04:40 – Trust and clinical accountability
06:52 – Educating clinicians on AI use

In this first deep dive, Byrne explores how AI is revolutionising inflammatory bowel disease care. He discusses the DovaVision™ UC (Dova Health Intelligence, Vancouver, Canada) Mayo Endoscopic Score developed with the Mayo Clinic; the power of multimodal AI in combining colonoscopy, ultrasound, and lab data; and how AI reduces interobserver variability in disease scoring.

Timestamps:
01:04 – The landscape of AI in inflammatory bowel disease
02:54 – DovaVision™ UC (Dova Health Intelligence, Vancouver, Canada) Mayo collaboration
04:26 – Colonoscopy and AI
08:30 – The future of multimodal AI

Michael Byrne joins the EMJ Podcast to tackle rapid-fire questions on AI's role in gastroenterology. From clinical misconceptions to the biggest breakthroughs in endoscopy, discover how intelligent tools are redefining precision medicine in inflammatory bowel disease.

In this special countdown episode, the EMJ Podcast team looks back at the 10 highest-performing episodes of 2025. Spanning neurology, cardiology, gastroenterology, women's health, respiratory medicine, and digital innovation, these conversations captured the topics that mattered most to clinicians worldwide. From chronic pain and anxiety to glucagon-like peptide-1 therapies, antimicrobial stewardship, and extended reality in medicine, this episode revisits the expert insights, emerging ideas, and clinical debates that shaped healthcare discussions throughout the year.

Timestamps:

00:00 – Introduction: the year in review
01:52 – Gravity and human health
06:28 – Antimicrobial stewardship in children
10:15 – Healthcare communication and leadership
13:04 – Rare lung diseases and early diagnosis
16:56 – Colonoscopy and cancer prevention
21:17 – Extended reality in clinical care
25:25 – Advances in heart failure research
34:07 – Obesity management in the GLP-1 era
20:35 – Women's health across borders
39:40 – The pain–anxiety connection

In this third and final deep-dive episode, Nicholas Simmonds highlights the importance of collaborative networks, such as the European Cystic Fibrosis Society (ECFS) Clinical Trials Network, in enabling global clinical trials. He also emphasises the central role of the patient voice in developing new therapies, using CFTR modulators as a key example.

Timestamps:

00:00 – Introduction

00:55 – ECFS Network

03:29 – Trial design

04:54 – Therapy frontiers

07:48 – Curative approaches

13:07 – Clinician message

How is cystic fibrosis diagnosis evolving? In this second deep dive, Nicholas Simmonds explores advances in diagnostic tools and shares his experience with the CF registry, highlighting its value as a powerful resource for tracking long-term treatment effectiveness. A must-listen for clinicians and anyone interested in how cystic fibrosis is diagnosed, and how progress is monitored over time.

Timestamps:

00:00 – Introduction

00:52 – Adulthood diagnosis

06:00 – Advanced diagnostics

10:37 – Survival variability

15:05 – CF Registry

Nicholas Simmonds joins host Saranya Ravindran for a deep dive into how adult cystic fibrosis (CF) care is evolving. Drawing on decades of experience, he discusses the major shifts in adult CF management, the vulnerable transition from paediatric to adult services, and strategies that ensure a smooth handover. Explore how longer survival brings new challenges, from fertility to mental health and emerging comorbidities, and why continuity of multidisciplinary care is more crucial than ever.

Timestamps:

00:00 – Introduction

01:15 – Adult care

04:12 – Smooth handover

10:10 – Evolving needs