1. In this first deep dive, Bassetti discusses the changing landscape of antimicrobial resistance in hospitals and ICUs, the challenges of multidrug-resistant Gram-negative bacteria, and the vulnerability of patients who are critically ill and immunocompromised. He explores how diagnosis, empiric therapy, and therapeutic monitoring influence outcomes and resistance.

Timestamps:

01:09 – Antimicrobial resistance trends

04:06 – Tackling sepsis

06:39 – Gram-negative threat

08:15 – Vulnerable populations

10:00 – Diagnosis and empiric therapy

12:14 – Dosing and pharmacokinetics

14:32 – Antibiotic allergies

Matteo Bassetti joins the EMJ Podcast for a rapid-fire discussion on antimicrobial resistance in hospitals. From prescribing pitfalls to early versus precise antibiotic use, he shares insights on howantimicrobial resistance is impacting real-world clinical care.

Drawing on her landmark work in HIV and vaccine research, Glenda Gray shares powerful lessons for tackling AMR in this last deep dive episode. From prevention and behavioural science to protecting high-risk populations, she explains how strategies that transformed HIV outcomes can inform a more effective and equitable AMR response.

Timestamps:
00:00 – Introduction

01:02 – Lessons from HIV

02:47 – Vaccine trials

03:50 – AMR interventions

05:17 – Behavioural science

06:31 – Key takeaways

In this second deep dive, Glenda Gray examines why the global antibiotic pipeline is failing and how access gaps are fuelling resistance. She discusses GARDP's mission-driven research and development model, the neglect of paediatric antibiotics, and how shortages of first-line treatments drive reliance on last-resort drugs, worsening the antimicrobial resistance crisis.

Timestamps:
00:00 – Introduction

00:58 – Antibiotic development

03:05 – GARDP's model

04:15 – Paediatric antibiotics

04:58 – Antibiotic shortages

05:50 – Access gaps

In this first deep dive, Glenda Gray unpacks what antimicrobial resistance means for clinicians beyond infectious diseases, and why it is already a leading cause of death globally. She explores the disproportionate burden in low- and middle-income countries, the devastating impact on neonates and infants, and the critical role of diagnostics, vaccines, and infection prevention.

Timestamps:
00:00 – Introduction

00:45 – What is AMR?

01:32 – Burden on LMICs

02:57 – Impact on infants

04:05 – Diagnostic gaps

05:10 – Comprehensive strategies

Glenda Gray joins the EMJ Podcast for a quickfire discussion on antimicrobial resistance and child health. From antibiotic misconceptions to equitable access and stewardship, she shares sharp insights into why AMR is a defining global health challenge for children today.

Description: The final deep dive episode looks ahead: stem cells, tissue transplantation, fertility preservation in cancer care, and the policy challenges limiting access to advanced male infertility treatment. A future-facing discussion on cures and equity.

Timestamps:
00:00 – Introduction

01:02 – Stem cells

04:08 – Fertility preservation

05:04 – Access and cost

07:04 – Pricing variability

08:20 – What's next?