Ask a question of ChatGPT and other, similar chatbots and there’s a good chance you’ll be impressed at how adeptly it comes up with a good answer — unless it spits out unrealistic nonsense instead. Part of what’s mystifying about these kinds of machine learning systems is that they are fundamentally black boxes. No one knows precisely how they arrive at the answers that they do. Given that mystery, is it possible that these systems in some way truly understand the world and the questions they answer? In this episode, the computer scientist Yejin Choi of the University of Washington and host Steven Strogatz discuss the capabilities and limitations of chatbots and the large language models, or LLMs, on which they are built.

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In the tiling of wallpaper and bathroom floors, collective repeated patterns often emerge. Mathematicians have long tried to find a tiling shape that never repeats in this way. In 2023, they lauded an unexpected amateur victor. That discovery of the elusive aperiodic monotile propelled the field into new dimensions.

The study of tessellation is much more than a fun thought exercise: Peculiar, rare tiling formations can sometimes seem to tell us something about the natural world, from the structure of minerals to the organization of the cosmos. In this episode, Janna Levin speaks with mathematician Natalie Priebe Frank about these complex geometric combinations, and where they may pop up unexpectedly. Specifically, they explore her research into quasicrystals — crystals that, like aperiodic tiles, enigmatically resist structural uniformity..

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The universe seems like it should be unfathomably complex. How then is science able to crack fundamental questions about nature and life? Scientists and philosophers alike have often commented on the “unreasonable” success of mathematics at describing the universe. That success has helped science probe some profound mysteries — but as the physicist Nigel Goldenfeld points out, it also helps that the “hard” physical sciences, where this progress is most evident, are in major ways simpler than the “soft” biological sciences.

In this episode, Goldenfeld speaks with co-host Steven Strogatz about the scientific importance of asking the right questions at the right time. They also discuss the mysterious effects of “emergence,” the phenomenon that allows new properties to arise in systems at different scales, imposing unexpected order on cosmic complexity.

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During traumatic periods and their aftermath, our brains can fall into habitual ways of thinking that may be helpful in the short run but become maladaptive years later. For the brain to readjust to new situations later in life, it needs to be restored to the malleable state it was in when the habits first formed. That is exactly what Gül Dölen, a neuroscientist and psychiatric researcher at the University of California, Berkeley, is working toward in her lab. What is her surprising tool? Psychedelics.

In this episode, Dölen shares with co-host Janna Levin the surprising potential of psychedelics to change the lives of those grappling with addiction, depression and post-traumatic stress.

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For decades, the best drug therapies for treating depression, like SSRIs, have been based on the idea that depressed brains don’t have enough of the neurotransmitter serotonin. Yet for almost as long, it’s been clear that simplistic theory is wrong. Recent research into the true causes of depression is finding clues in other neurotransmitters and the realization that the brain is much more adaptable than scientists once imagined. Treatments for depression are being reinvented by drugs like ketamine that can help regrow synapses, which can in turn restore the right brain chemistry and improve whole body health.

In this episode, John Krystal, a neuropharmacologist at the Yale School of Medicine, shares the new findings in mental health research that are revolutionizing psychiatric medication.

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If superconductors — materials that conduct electricity without any resistance — worked at temperatures and pressures close to what we would consider normal, they would be world-changing. They could dramatically amplify power grids, levitate high-speed trains and enable more affordable medical technologies. For more than a century, physicists have tinkered with different compounds and environmental conditions in pursuit of this elusive property, but while success has sometimes been claimed, the reports were always debunked or withdrawn. What makes this challenge so tricky?

In this episode, Siddharth Shanker Saxena, a condensed-matter physicist at the University of Cambridge, gives co-host Janna Levin the details about why high-temperature superconductors remain so stubbornly out of reach..

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Milk is more than just a food for babies. Breast milk has evolved to deliver thousands of diverse molecules including growth factors, hormones and antibodies, as well as microbes.

Elizabeth Johnson, a molecular nutritionist at Cornell University, studies the effects of infants’ diet on the gut microbiome. These studies could hold clues to hard questions in public health for children and adults alike. In this episode of “The Joy of Why” podcast, co-host Steven Strogatz interviews Johnson about the microbial components that make breast milk one of the most wondrous biofluids found in nature.

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Nothing escapes a black hole … or does it? In the 1970s, the physicist Stephen Hawking described a subtle process by which black holes can “evaporate,” with some particles evading gravitational oblivion. That phenomenon, now dubbed Hawking radiation, seems at odds with general relativity, and it raises an even weirder question: If particles can escape, do they preserve any information about the matter that was obliterated?

Leonard Susskind, a physicist at Stanford University, found himself at odds with Hawking over the answer. In this episode, co-host Janna Levin speaks with Susskind about the “black hole war” that ensued and the powerful scientific lessons to be drawn from one of the most famous paradoxes in physics.

Listen on Apple Podcasts, Spotify, TuneIn or your favorite podcasting app, or you can stream it from Quanta.