Identifying reliable biomarkers for the diagnosis and prognosis of Parkinson's disease and atypical parkinsonism would have substantial impacts on clinical trials and clinical practice. A particularly active area of research is the development of novel molecular imaging biomarkers that can be used in combination with common neuroimaging approaches. Dr. Antonio Strafella discusses current practices for using molecular imaging biomarkers in research and in the clinic, the process of developing new biomarkers, as well as promising biomarkers that are in development. He also discusses limitations, implementation challenges, and the potential use of AI to enhance diagnostics in the future. Antonio is the Krembil-Rossy Chair in Molecular Imaging of Neurodegenerative Diseases and Professor in the Department of Medicine within the Division of Neurology at the Toronto Western Hospital (University Health Network, University of Toronto). He also serves as Director of Clinical Research and Translation with the Temerty Faculty of Medicine at the University Toronto, and he is a movement disorder neurologist in the Edmond J. Safra Program in Parkinson’s Disease and Morton & Gloria Shulman Movement Disorders Clinic at the Toronto Western Hospital.

This podcast is geared toward researchers and clinicians. If you live with Parkinson’s or have a friend or family member with PD, listen to The Michael J. Fox Foundation Parkinson’s Podcast. Hear from scientists, doctors and people with Parkinson's on different aspects of life with the disease as well as research toward treatment breakthroughs at https://www.michaeljfox.org/podcasts.

Prior studies have established links between poor olfaction and Parkinson's disease, and impaired sense of smell is a common prodromal symptom of Parkinson's disease. The causes and mechanisms of prodromal neurodegeneration are actively being researched. However, environmental exposure to pesticides or other chemicals may trigger or modify the course of neurodegeneration, potentially leading to the development of Parkinson's disease over time. In this episode, Dr. Honglei Chen shares his research on environmental causes of neurodegenerative diseases, focusing particularly on evidence linking olfaction, environmental exposure, and Parkinson’s disease. Better understanding how environmental factors may contribute (alone or in combination with genetic factors) to the pathogenesis of Parkinson's disease may lead to new approaches to prevent or slow the progression of neurodegeneration. Honglei is the MSU Research Foundation Professor of Epidemiology and Biostatistics at Michigan State University.

This podcast is geared toward researchers and clinicians. If you live with Parkinson’s or have a friend or family member with PD, listen to The Michael J. Fox Foundation Parkinson’s Podcast. Hear from scientists, doctors and people with Parkinson's on different aspects of life with the disease as well as research toward treatment breakthroughs at https://www.michaeljfox.org/podcasts.

Gait impairments such as slow speed, small steps, and high variability from step to step are common in people with Parkinson's disease, and these changes begin to occur early in the course of disease. Freezing of gait may develop later for some individuals, and it has been linked to falls and other adverse outcomes. When the quality of walking declines, it can lead to a reduction in the quantity of walking and overall physical activity, which is also related to poorer health outcomes. To prevent this cascade of events, Dr. Gammon Earhart is developing and evaluating interventions to improve gait and increase physical activity in People with Parkinson's disease. In this episode, she discusses how she and collaborators are conducting studies on different approaches, including a mobile health application, self-generated rhythmic cues in the form of singing, and mindfulness training, to improve aspects of walking and physical activity in people with Parkinson's disease. Gammon is Professor of Physical Therapy, Neurology, and Neuroscience, Associate Dean for Physical Therapy, and Director of the Program in Physical Therapy at Washington University School of Medicine in St. Louis.

This podcast is geared toward researchers and clinicians. If you live with Parkinson’s or have a friend or family member with PD, listen to The Michael J. Fox Foundation Parkinson’s Podcast. Hear from scientists, doctors and people with Parkinson's on different aspects of life with the disease as well as research toward treatment breakthroughs at https://www.michaeljfox.org/podcasts.