Episodios

  • Mosquitoes Fall for FUNGI!

    Mosquitoes Fall for FUNGI!
    Nov 5 2025
    What the if mosquitoes were helpless against the sweet smell of their own doom? Scientists genetically engineered Metarhizium fungus to smell so irresistibly delicious that mosquitoes can't help but fly straight into deadly traps with a 90-100% success rate. Discover why these bloodsuckers are actually tiny recycling agents in nature (who knew?), learn why we can't just eliminate them without the whole ecosystem throwing a tantrum, and find out why one will inevitably end up on a future space station driving the crew absolutely bonkers. From glowing green fungus-covered mosquitoes that look like tiny Marvel villains to biological pest control that beats slathering industrial chemicals on everything, explore humanity's eternal quest to outsmart bugs that have been annoying us since the dawn of time. Based on "This Genetically Engineered Fungus Could Help Fix Your Mosquito Problem" by Jason Dinh, published in The New York Times on November 1st, 2025. Read the full article here: https://www.nytimes.com/2025/11/01/science/fungus-mosquitoes-genetic-engineering.html?unlocked_article_code=1.y08.x0jx.9OuE2HKzYyez&smid=url-share --- Find out more about Gaby's science fiction short story! Here are the links for the anthology. The physical copy can be ordered here : https://www.neonhemlock.com/books/luminescent-machinations-queer-tales-of-monumental-invention The ebook can be ordered here: https://www.neonhemlock.com/ebooks/luminescent-machinations-queer-tales-of-monumental-invention
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    41 m
  • FRANKENSTEIN

    FRANKENSTEIN
    Oct 31 2025
    What the if Frankenstein was real and doctors actually tried stitching corpses together to create new people? Forget dramatic lightning strikes and brooding in Gothic towers - the real adventure is managing the world's most complicated pharmacy order when seventeen different immune systems meet for the first time and immediately start fighting. Join us as we explore why creating a functional monster requires less "It's alive!" moments and more "Does this insurance plan cover interdimensional tissue rejection?", discover the eternal question of whose blood type gets to be in charge, and meet today's synthetic biology scientists who figured out you can just build new life from genes like tiny biological LEGO blocks. Turns out whether you're using body parts or DNA, humanity's been enthusiastically playing god for centuries - we've just gotten way better at the paperwork.
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    46 m
  • The BURPING Lake!

    The BURPING Lake!
    Oct 22 2025
    What the if all bodies of water on Earth were fizzy like soda? In the real world, Seneca Lake in New York produces mysterious underwater booms called "Seneca guns" that scientists think come from occasional gas pockets, but nobody knows for sure. But in our imaginary world where every lake constantly fizzes like champagne, Chicago would relocate to the mountains as Lake Michigan burps methane clouds all day long. New York and London would move to higher ground, while only brave "soda dwellers" would live at water level like Mad Max characters in vans by the river. Niagara Falls would transform into a methane-harvesting factory with enormous vacuum cleaners shipping gas to Texas for barbecue. Cities would rebuild on mountainsides and clifftops, everyone would construct homes on stilts near shores, and Mentos would become weapons of mass destruction capable of triggering lake explosions. Based on "Why is this lake burping?" published in The New York Times on Oct. 8, 2025: https://www.nytimes.com/2025/10/08/nyregion/seneca-lake-guns-drums.html?unlocked_article_code=1.vU8.hjhV.kfNyB5WcMwSr&smid=url-share --- Find out more about Gaby's science fiction short story! Here are the links for the anthology. The physical copy can be ordered here : https://www.neonhemlock.com/books/luminescent-machinations-queer-tales-of-monumental-invention The ebook can be ordered here: https://www.neonhemlock.com/ebooks/luminescent-machinations-queer-tales-of-monumental-invention
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    45 m
  • Animals Train YOU!

    Animals Train YOU!
    Oct 15 2025
    Honey guide birds in Africa respond to culturally distinct human calls and lead hunters to beehives, where humans crack them open and birds feast on the exposed beeswax. But what the if humans could whistle for any wild animal to help with tasks? Call a deer to haul your Costco groceries home (extra cabbage as payment), summon crows to find your lost earring for peanuts, or live in a Viking village where bears help with the salmon harvest then hibernate in someone's hut all winter. From turkey truffle-hunting to dolphins demanding space station aquariums, explore a world where wild animals and humans exist in bizarre symbiotic relationships that might have prevented industrialization altogether. Based on "Honeyguide Birds Learn Culturally Distinct Calls Made By Honey Hunters" by Walter Beckwith, published in AAAS Science on December 11, 2023. Read the full article at https://www.aaas.org/news/honeyguide-birds-learn-culturally-distinct-calls-made-honey-hunters --- Find out more about Gaby's science fiction short story! Here are the links for the anthology. The physical copy can be ordered here : https://www.neonhemlock.com/books/luminescent-machinations-queer-tales-of-monumental-invention The ebook can be ordered here: https://www.neonhemlock.com/ebooks/luminescent-machinations-queer-tales-of-monumental-invention
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    41 m
  • AI Viruses

    AI Viruses
    Oct 3 2025
    Scientists just used artificial intelligence to design the world's first AI-generated viruses capable of hunting down and killing drug-resistant strains of E. coli. These bacteriophages look like tiny alien pineapples with syringes that stab bacterial cells, and they're just the beginning of AI-created life. From Matt's dream of dish-cleaning bacteria that won't eat you (hopefully) to the accidental discovery that trying to make super purple petunias actually created white flowers instead, this episode explores what the if happens when computers start writing genetic code. Discover why we're running out of antibiotics, how a virus with only 11 genes works, and why your future dish soap bottle might say "now with AI inside." Plus, learn about the scientist who tried to engineer the most purple petunias ever and accidentally won a Nobel Prize instead. Based on "World's First AI Designed Viruses: A Step Towards AI Generated Life" by Katie Kavanagh, published in Nature on September 19, 2025. https://www.nature.com/articles/d41586-025-03055-y Matt also mentions a book worth checking out during the episode: "The Genealogy of a Gene: Patents, HIV/AIDS, and Race" by Myles W. Jackson, published by MIT Press. The book explores how intellectual property law has transformed scientific research through the fascinating story of the CCR5 gene, examining everything from Big Pharma to personalized medicine. Learn more at https://mitpress.mit.edu/9780262533782/the-genealogy-of-a-gene/ --- Find out more about Gaby's science fiction short story! Here are the links for the anthology. The physical copy can be ordered here : https://www.neonhemlock.com/books/luminescent-machinations-queer-tales-of-monumental-invention The ebook can be ordered here: https://www.neonhemlock.com/ebooks/luminescent-machinations-queer-tales-of-monumental-invention
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    54 m
  • MEMORY Maxed Out - with Nikolay Kukushkin!

    MEMORY Maxed Out - with Nikolay Kukushkin!
    Sep 26 2025
    What the if your brain literally ran out of storage space like a laptop refusing to save one more file? Neuroscientist Nikolay Kukushkin explains how memory isn't a filing cabinet but more like water carving rivers down a mountain - and when you carve too many paths, everything becomes a muddy mess. Discover why Mr. S, who remembered everything perfectly, couldn't recognize faces or taste food because his brain was too full of details. Learn why sleep is your brain's nightly cleanup crew and why we're all currently running at 98% memory capacity thanks to information overload. Plus, find out why forgetting your ex might also wipe out your algebra skills, and how even your kidney cells form their own minute-by-minute memories. Our guest is Nikolay Kukushkin, neuroscientist at NYU and author of "One Hand Clapping: Unraveling the Mystery of the Human Mind." You can learn more about Nikolay's fascinating book at https://www.simonandschuster.com/books/One-Hand-Clapping/Nikolay-Kukushkin/9781493090648 --- Check out our membership rewards! Visit us at Patreon.com/Whattheif Got an IF of your own? Want to have us consider your idea for a show topic? Send YOUR IF to us! Email us at feedback@whattheif.com and let us know what's in your imagination. No idea is too small, or too big!Keep On IFFin',Philip, Matt & Gaby
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    59 m
  • Gravity Waves Go WIGGLE

    Gravity Waves Go WIGGLE
    Sep 19 2025
    What the if gravitational waves were big enough to see and feel? Instead of measuring distortions smaller than a proton, imagine watching your coffee table accordion in and out as ripples from distant black hole collisions pass through your local cafe. Every time Charlie the cat bats a toy mouse in Greenwich Village, sugar cubes scrunch in Williamsburg cafes. Brain surgeons would need to ask all of New York to sit perfectly still during operations to avoid gravitational interference. Even parking lots would seem impossibly far away one moment and right next to you the next as space itself stretches and compresses. From squirrels disrupting billion-dollar physics experiments to the strange world of noise-canceling gravity waves, discover why LIGO's incredible ability to detect universe-shaking events that distort space by one ten-thousandth the width of a proton might actually be humanity's most impressive scientific achievement. Based on "Happy Birthday, LIGO. Now Drop Dead." by Dennis Overby, published in The New York Times on September 10, 2025: https://www.nytimes.com/2025/09/10/science/gravitational-waves-ligo-black-holes.html?unlocked_article_code=1.nE8.QM2f.ag_83DD_kR8e&smid=url-share Learn More: "Gravity's Kiss: The Detection of Gravitational Waves" - https://mitpress.mit.edu/9780262535120/gravitys-kiss/ Matt mentioned sociologist Harry Collins' nearly 900-page masterpiece about gravity wave detection as the first book he ever reviewed; find this comprehensive account of one of science's most remarkable discoveries written by someone embedded in the gravitational wave community for over 40 years. Professor Tiffany Nichols - https://cssh.northeastern.edu/faculty/tiffany-nichols/ Matt recommended his friend Tiffany's dissertation (soon to be a book) about how LIGO chose their detection sites; explore her research on the epic story of selecting locations for these mile-long instruments and how surrounding environments become part of the scientific process. What are Gravitational Waves - https://www.ligo.caltech.edu/page/what-are-gw Learn about the ripples in space-time that we imagined making visible in our thought experiment, including how these waves from colliding black holes create distortions 10,000 times smaller than an atomic nucleus. What is LIGO - https://www.ligo.caltech.edu/page/what-is-ligo Discover how this unique observatory uses 4-kilometer-long laser interferometers to detect the universe's most violent events, from the instrument that Matt described as humanity's most sensitive measurement device. --- Find out more about Gaby's science fiction short story! Here are the links for the anthology. The physical copy can be ordered here : https://www.neonhemlock.com/books/luminescent-machinations-queer-tales-of-monumental-invention The ebook can be ordered here: https://www.neonhemlock.com/ebooks/luminescent-machinations-queer-tales-of-monumental-invention
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    50 m
  • Science ROCKS On MARS!

    Science ROCKS On MARS!
    Sep 12 2025
    What the if you found a rock on Mars that might - emphasis on might - show signs of ancient life? NASA's Perseverance rover discovered intriguing leopard spots in a 3.5-billion-year-old rock that contain vivianite, a mineral that could potentially indicate biological activity, though scientists remain cautiously skeptical. These dark-outlined splotches bear some resemblance to patterns that microbes can leave behind, but resemblance isn't proof. Join our trio as they explore the painstaking scientific process of investigating possible signs of life from tens of millions of miles away using lasers, spectroscopes, and instruments cleverly named Sherlock and Watson. From "poppy seed" nodules to the methodical work of ruling out every conceivable non-biological explanation, discover why scientists are being extraordinarily careful about what could potentially be intriguing evidence - if it survives rigorous scrutiny. Based on "In a Rock on Mars, NASA Sees Clearest Sign of Life (So Far)" by Kenneth Chang, published in The New York Times on September 10, 2025 Read the full article here: https://www.nytimes.com/2025/09/10/science/mars-rock-nasa-perserverance.html?unlocked_article_code=1.lE8.UiKA.kl-1r33U-Pd9&smid=url-share --- Find out more about Gaby's science fiction short story! Here are the links for the anthology. The physical copy can be ordered here : https://www.neonhemlock.com/books/luminescent-machinations-queer-tales-of-monumental-invention The ebook can be ordered here: https://www.neonhemlock.com/ebooks/luminescent-machinations-queer-tales-of-monumental-invention
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    57 m