Can real-time EHR–generated recommendations safely reduce antibiotic use in hospitalized patients with pneumonia or UTI? Shruti K. Gohil, MD, MPH, of the University of California-Irvine, joins JAMA Deputy Editor Preeti Malani, MD, MSJ, to discuss the INSPIRE randomized clinical trial.

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• Stewardship Prompts to Improve Antibiotic Selection for Pneumonia
• Stewardship Prompts to Improve Antibiotic Selection for Urinary Tract Infection
• Harnessing the Electronic Health Record to Improve Empiric Antibiotic Prescribing

Climate action is an urgent public health imperative. Climate change is causing excess morbidity and mortality and posing an increasing threat to mental health and well-being. The US health care sector is a significant contributor to this problem. A. Eugene Washington, MD, of Duke University, discusses accelerating climate action with JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS.

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• Accelerating Climate Action Through Academic Health Systems

The utility of prostate-specific antigen (PSA) screening for prostate cancer detection is impacted by detection of cancers with low risk of mortality. Editorialist Jeffrey J. Tosoian, MD, MPH, discusses a pragmatic approach to prostate cancer screening with JAMA Deputy Editor Mary L. (Nora) Disis, MD.

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• A Pragmatic Approach to Prostate Cancer Screening
• Prostate Cancer Screening With PSA, Kallikrein Panel, and MRI
• Prostate-Specific Antigen Screening and 15-Year Prostate Cancer Mortality