For the first time, investor Guy Spier steps outside the world of finance to share a deeply personal conversation—with the doctors who treated him.

Recorded at the University Hospital Münster, this discussion with neurosurgeon Dr. Michael Müther and radiation oncologist Dr. Niklas Pepper explores the frontiers of brain cancer treatment, focusing on glioblastoma and a groundbreaking clinical trial combining 5-ALA (Gliolan®) with radiotherapy.

Topics covered:

What glioblastoma is and why it’s so difficult to treat

The Stupp protocol and why recurrence is common

How 5-ALA fluorescence surgery helps surgeons “see” tumors

The role and evolution of radiotherapy and re-irradiation

A new approach: radiodynamic therapy (5-ALA + radiation)

How clinical trials work (Phase I, dose escalation, safety focus)

Why patient participation is critical to medical progress

The conversation also explores the human side of medicine:

Should patients deeply engage with their disease—or not?

The role of mindset, movement, and psycho-oncology

How doctors balance research, clinical care, and uncertainty

This is a rare, candid look at how modern medicine advances—from lab to patient—and the people behind it.

Chapters:

00:00 Introduction

03:10 What is glioblastoma?

06:00 5-ALA and fluorescence-guided surgery

12:37 Radiotherapy explained

17:39 Re-irradiation and treatment evolution

23:50 The new clinical trial (radiodynamic therapy)

35:48 How clinical trials work (Phase I, dose escalation)

45:39 Collaboration in cancer research

53:32 Why Germany leads in this field

59:03 Patient involvement in research

01:01:41 The psychology of disease

01:06:32 Final thoughts

Transcript to the whole episode is available here: https://aqfd.docsend.com/view/5gbyupsrddq9ieda

Disclaimer:

Nothing contained herein constitutes or should be construed as medical advice. No representations or warranties are made regarding the accuracy or completeness of the information, and it should not be used as a substitute for consultation with a licensed healthcare provider.

In this episode, Guy Spier speaks with Ritavan and Paaras about how businesses can unlock real value through data—not by chasing trends like AI or cloud, but by leveraging data purposefully. Ritavan shares insights from his book Data Impact, discussing how legacy companies often fall into the trap of tech commoditization.

Learn how to:

• Use data leverage for outsized returns
• Prioritize high-impact “leverage tasks” like dynamic pricing
• Avoid wasteful tech adoption and focus on differentiation
• Apply real-world examples from Walmart, Octopus Energy, Bajaj Finance & more

Full transcript available here: https://aqfd.docsend.com/view/sqgp7wsixsgvevsk

Contents:

(00:00:00) Introductions and First Impressions

(00:05:25) Ritavan’s Journey and Cultural Insights

(00:17:52) Writing “Data Impact” and Global Examples

(00:29:18) Data Strategy for Legacy Businesses

(00:41:32) Big Bets and Data as Leverage

(00:50:30) Content Strategy and Power Laws

What happens when a thoughtful investor sits down with a contrarian academic for a free-flowing, two-hour conversation? In this wide-ranging episode, Guy Spier reconnects with his former professor, Amar Bhidé, who’s the Professor of Health Policy at Columbia University Medical Center, for a dialogue that blurs the lines between economics, storytelling, philosophy, and life itself.

They begin by reflecting on paths taken—and those deliberately left behind. Professor Bhidé shares how a winding career through finance, policy, and academia has shaped his unconventional views on business education and the role of theory.

At the heart of the conversation is a simple but profound distinction: risk versus uncertainty. But this is no dry academic discussion. Instead, it opens into a deeper exploration of how we make decisions, how we explain the world, and why models often fail to capture what matters most.

Stories play a starring role—stories in business, in investing, in life. The two explore why narratives move us, how they can deceive, and what they reveal about human nature. From entrepreneurs to generals, from investors to doctors, Professor Bhidé argues that judgment and imagination remain our most vital tools.

There are digressions, of course—beautiful ones. Into mythology and scripture, literature and logic. Into why certain minds captivate us, and why what we choose to read says something about how we choose to live.

This isn’t a podcast about one big idea—it’s about many. And the spaces between them. It’s about learning to see and finding meaning—quietly, sometimes stubbornly—just beyond the known.

Full transcript available here: https://aqfd.docsend.com/view/g2vwrtr7yiq9cwnp

(00:00:00) Setting the Stage: Uncertainty, Progress, and a Life’s Work

(00:06:21) A Distinction That Matters

(00:14:46) The Power of Plausibility: How Investors Use Stories to Decide

(00:22:20) Data Can’t Dream: Why Judgment and Imagination Still Rule

(00:28:34) First Principles, Human Realities: Rethinking How We Know

(00:47:55) More Than Facts: How Stories Shape Action and Identity

(00:55:49) Duty Without Reward: Eastern Philosophy Meets the Business Mind

(01:03:27) Happy with Small Takes: Reflections on Power, History, and the Self

(01:10:36) Books, Minds, and Conversations That Stay With You