Lifespan with Dr. David Sinclair By cover art

Lifespan with Dr. David Sinclair

By: Lifespan Communications LLC
Listen for free

  • Summary

  • Join Dr. David Sinclair, Ph.D. in Lifespan, a popular health podcast that brings the cutting edge of aging and longevity science straight to you. Hear about the latest developments in aging research, lifestyle practices for longevity, exercise and nutrition science, and more. This podcast is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice.
    Lifespan Communications LLC
    Show more Show less
Episodes
  • Biotracking, Age Reversal & Other Advanced Health Technologies | Episode 8

    Biotracking, Age Reversal & Other Advanced Health Technologies | Episode 8
    Feb 23 2022

    In the final episode of this season, Dr. David Sinclair and Matthew LaPlante focus on current and near-future technologies relevant to health and aging. In addition to discussing the utility of wearable sensors and biological age measurements, they highlight innovative research aimed at reversing biological age. The societal effects of therapies that successfully extend healthspan and/or lifespan are also considered.

    Thank you to our sponsors:

    • Levels - https://levels.link/sinclair
    • Athletic Greens - https://athleticgreens.com/sinclair
    • InsideTracker - https://insidetracker.com/sinclair

    Our Patreon page: https://www.patreon.com/davidsinclair 

    Lifespan book: https://amzn.to/3sUqurT

    Dr. David Sinclair Social:

    • Instagram
    • Twitter
    • Facebook

    Matthew LaPlante's Social:

    • Twitter

    To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.

    Timestamps:

    (00:00:00) Introducing Episode Eight: The Future of Anti-aging Medicine

    (00:03:49) Thanking the Sponsors

    (00:06:48) Modern Healthcare, Disease Detection, and Circulating DNA

    (00:11:30) Wearable Monitors: A Dashboard for your Body

    (00:20:31) Types of Health Sensors

    (00:24:20) Big Data, Privacy, and Criminal Investigation

    (00:30:16) Cutting-edge Testing and Biological Age

    (00:36:40) Using Personalized Data to Inform your Diet

    (00:41:48) Optimizing Exercise and Activity-mimetics

    (00:45:02) Resetting the Aging Clock

    (00:53:45) Repeatable Age Reversal and Safety

    (00:56:11) Longer Life, Population Size, and Economics

    (01:00:18) Skillbatical

    (01:03:06) Putting in the Work for Longevity

    (01:04:56) Thanking the Podcast Team and Wrapping Up Season One

    (01:08:27) Options for Subscription and Support

    For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.

    Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

    Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.
    Show more Show less
    1 hr and 9 mins
  • The Science of Keeping the Brain Healthy | Episode 7

    The Science of Keeping the Brain Healthy | Episode 7
    Feb 16 2022

    In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep.

    Thank you to our sponsors:

    • Athletic Greens - https://athleticgreens.com/sinclair
    • Levels - https://levels.link/sinclair
    • InsideTracker - https://insidetracker.com/sinclair

    Our Patreon page: https://www.patreon.com/davidsinclair 

    Lifespan book: https://amzn.to/3sUqurT

    Dr. David Sinclair Social:

    • Instagram
    • Twitter
    • Facebook

    Matthew LaPlante's Social:

    • Twitter

    To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.

    Timestamps:

    (00:00:00) Introducing Episode Seven: Aging of the Brain

    (00:04:39) Thanking the Sponsors

    (00:07:38) Ex-differentiation as a Driver of Aging

    (00:09:22) The Brain Ages Slowly

    (00:14:17) Cognitive Function and Plasticity

    (00:17:44) Three Longevity Pathways: mTOR, AMPK, and Sirtuins

    (00:23:26) Plant-based Diets and B-vitamins

    (00:28:32) Homocysteine, Plaque, and Vasculature

    (00:32:35) Fatty Acids

    (00:35:48) Physical Activity

    (00:39:14) Metformin

    (00:46:02) NAD Boosters

    (00:50:33) Increasing Blood Flor

    (00:53:20) Sleep

    (00:58:02) Overall Message: Keep your Brain Healthy

    (00:58:50) Next Week’s Episode and the Future of Medicine

    (01:01:21) Options for Subscription for Support

    For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.

    Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

    Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.
    Show more Show less
    1 hr and 2 mins
  • The Science of Looking Younger, Longer | Episode 6

    The Science of Looking Younger, Longer | Episode 6
    Feb 9 2022

    In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. The latest science behind various beautifying therapies is highlighted, including newer interventions like low-level laser therapy and platelet-rich plasma injections.

    Thank you to our sponsors:

    • Athletic Greens - https://athleticgreens.com/sinclair
    • Levels - https://levels.link/sinclair
    • InsideTracker - https://insidetracker.com/sinclair

    Our Patreon page: https://www.patreon.com/davidsinclair 

    Lifespan book: https://amzn.to/3sUqurT

    Dr. David Sinclair Social:

    • Instagram
    • Twitter
    • Facebook

    Matthew LaPlante's Social:

    • Twitter

    To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.

    Timestamps:

    (00:00:00) Launching Episode Six: Combating Cosmetic Aging & Improving Skin, Nails & Hair

    (00:02:54) Estrogen, Progesterone, and Menopause

    (00:09:51) Thanking the Sponsors

    (00:12:57) The Pinch Test, Epidermal Thinning, and Foot Ulcers

    (00:18:29) Skin and Biological Aging

    (00:23:19) Cellular Senescence, Ultraviolet Light, and Skin Aging

    (00:28:15) Collagen, Keratin, and Skin Health

    (00:33:38) A Quick Aside about Nails

    (00:34:45) Autophagy and Retinoids

    (00:36:57) Resveratrol, NAD Boosters, and Hyaluronic Acid

    (00:41:44) Botox, Skin Peels, and Microneedling

    (00:43:28) No Duh Stuff: Sun Damage, Smoking, Alcohol, and Bad Food

    (00:45:42) Hair Loss and Hair Graying

    (00:49:45) Topical Treatments, Pills, and Dihydrotestosterone

    (00:55:19) Frickin Laser Beams: Low-level Laser Therapy

    (00:57:59) Platelet-rich Plasma (PRP) Injections

    (01:00:11) Hair Aging, Stress, and Gray Hair Reversal

    (01:06:11) Targeting Aging Upstream

    (01:07:37) Today’s Takeaways

    (01:09:25) Subscription and Support Options

    For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.

    Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

    Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.
    Show more Show less
    1 hr and 10 mins
Hygiene & Healthy Living
Show more Show less

What listeners say about Lifespan with Dr. David Sinclair

Average customer ratings
Overall
  • 5 out of 5 stars
  • 5 Stars
    55
  • 4 Stars
    1
  • 3 Stars
    1
  • 2 Stars
    1
  • 1 Stars
    0
Performance
  • 5 out of 5 stars
  • 5 Stars
    54
  • 4 Stars
    0
  • 3 Stars
    0
  • 2 Stars
    1
  • 1 Stars
    1
Story
  • 5 out of 5 stars
  • 5 Stars
    51
  • 4 Stars
    2
  • 3 Stars
    0
  • 2 Stars
    2
  • 1 Stars
    0

Reviews - Please select the tabs below to change the source of reviews.

Audible.com reviews

Amazon reviews
Sort by:
Filter by:
  • Overall
    5 out of 5 stars
  • Performance
    5 out of 5 stars
  • Story
    5 out of 5 stars
Profile Image for Grant Shipman

Latest Info Straight From the Source

I cannot say enough how much I appreciate this podcast. The two cohosts have great chemistry and compliment each other in a way that gives me, the listener, more comprehensive content. Learning about cutting edge longevity science from Dr Sinclair, who is at the cutting edge of this research, is a true gift. Thanks to both of them for this!

Report this

Something went wrong. Please try again in a few minutes.

You voted on this review!

You reported this review!

  • Overall
    5 out of 5 stars
  • Performance
    5 out of 5 stars
  • Story
    5 out of 5 stars
Profile Image for Julie B.

Thank you for doing this!

So insightful! Can tell you truly care about bringing forth info to the masses! Please continue and do more seasons, you do make a difference!!
Julie B

Report this

Something went wrong. Please try again in a few minutes.

You voted on this review!

You reported this review!

  • Overall
    5 out of 5 stars
  • Performance
    5 out of 5 stars
  • Story
    5 out of 5 stars
Profile Image for JK E.

Just amazing content

It's like getting a glimpse of the future. Please do another season. I would love to hear more on what to expect as I continue to age.

Report this

Something went wrong. Please try again in a few minutes.

You voted on this review!

You reported this review!

  • Overall
    5 out of 5 stars
  • Performance
    5 out of 5 stars
  • Story
    5 out of 5 stars
Profile Image for Amazon Customer

Great listen for longevity

Very interesting and with lots of research. I liked the show for clarification and referenced.




Report this

Something went wrong. Please try again in a few minutes.

You voted on this review!

You reported this review!

  • Overall
    5 out of 5 stars
  • Performance
    5 out of 5 stars
  • Story
    5 out of 5 stars
Profile Image for Velina D.

Excellent presentation and loads of information

Highly recommend to anyone young or elderly. Very easy to understand with practical recommendations to apply in every day life.

Report this

Something went wrong. Please try again in a few minutes.

You voted on this review!

You reported this review!

  • Overall
    5 out of 5 stars
  • Performance
    5 out of 5 stars
  • Story
    5 out of 5 stars
Profile Image for Zeshaan Maan

Great resource!

Loved it - particularly the framing of the facts to help avoid confusion for the uninitiated.

Report this

Something went wrong. Please try again in a few minutes.

You voted on this review!

You reported this review!

  • Overall
    5 out of 5 stars
  • Performance
    5 out of 5 stars
  • Story
    5 out of 5 stars
Profile Image for Lauren Superstar

Life changing and extending advice

I am so glad I heard about Dr. David Sinclair’s work on the Smartless podcast. I’ve read lifespan and this podcast gives even more up to date information.

Report this

Something went wrong. Please try again in a few minutes.

You voted on this review!

You reported this review!

  • Overall
    5 out of 5 stars
  • Performance
    5 out of 5 stars
  • Story
    5 out of 5 stars
Profile Image for Diana R.

Opportunity of a lifetime

Of over 500 books I’ve read in recent years, “Lifespan” is one of the ten most informative and life-changing. Everyone can benefit from knowing about the science of health/longevity.

I’d really value another podcast series, both to update us about new developments for supporting our health/longevity, and to present additional topics. A research and discussion omission I’d like to see remedied is female health/longevity issues, including differences between women and men.

Please consider omitting Matthew LaPlante’s “humor” and tightening your discussion by replacing chit-chat with helpful information.

Many thanks for the pearl you have added to my life’s string.

Report this

Something went wrong. Please try again in a few minutes.

You voted on this review!

You reported this review!

  • Overall
    5 out of 5 stars
  • Performance
    5 out of 5 stars
  • Story
    5 out of 5 stars
Profile Image for Honest Reviews 4 you

Educational easy to follow interesting

Educational science based information that's easy to follow, very interesting and very encouraging for all ages. Pleasant narrators.

Report this

Something went wrong. Please try again in a few minutes.

You voted on this review!

You reported this review!

  • Overall
    5 out of 5 stars
  • Performance
    5 out of 5 stars
  • Story
    5 out of 5 stars
Profile Image for Marra Votta

I can’t get enough of

I can’t get enough of this information, I think genetics are amazing. I first heard of David on Smartless and I have now listened to all of lifespan. I will even re listen to all of your podcasts. Please keep going !

Report this

Something went wrong. Please try again in a few minutes.

You voted on this review!

You reported this review!