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The Breakthrough
- Immunotherapy and the Race to Cure Cancer
- Narrado por: Will Collyer, Charles Graeber
- Duración: 7 h y 7 m
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Resumen del Editor
Follow along as this New York Times best-selling author details the astonishing scientific discovery of the code to unleashing the human immune system to fight in this "captivating and heartbreaking" book (The Wall Street Journal).
For decades, scientists have puzzled over one of medicine's most confounding mysteries: Why doesn't our immune system recognize and fight cancer the way it does other diseases, like the common cold?
As it turns out, the answer to that question can be traced to a series of tricks that cancer has developed to turn off normal immune responses - tricks that scientists have only recently discovered and learned to defeat. The result is what many are calling cancer's "penicillin moment", a revolutionary discovery in our understanding of cancer and how to beat it.
In The Breakthrough, New York Times best-selling author of The Good Nurse Charles Graeber guides listeners through the revolutionary scientific research bringing immunotherapy out of the realm of the miraculous and into the forefront of 21st-century medical science. As advances in the fields of cancer research and the human immune system continue to fuel a therapeutic arms race among biotech and pharmaceutical research centers around the world, the next step - harnessing the wealth of new information to create modern and more effective patient therapies - is unfolding at an unprecedented pace, rapidly redefining our relationship with this all-too-human disease.
Groundbreaking, riveting, and expertly told, The Breakthrough is the story of the game-changing scientific discoveries that unleash our natural ability to recognize and defeat cancer, as told through the experiences of the patients, physicians, and cancer immunotherapy researchers who are on the front lines. This is the incredible true story of the race to find a cure, a dispatch from the life-changing world of modern oncological science, and a brave new chapter in medical history.
PLEASE NOTE: When you purchase this title, the accompanying PDF will be available in your Audible Library along with the audio.
Reseñas de la Crítica
"Graeber concisely reviews the science of cancer...The risks of tinkering with an intricate immune system are obviously high, even perilous. But the potential reward is a cure. Exciting reading." (Booklist)
"There is no villain more ruthless than cancer, which has robbed us all of loved ones who had to endure untold suffering before they succumbed. But after decades of frustration and toil, scientists finally understand how to vanquish the disease by activating the human body's natural defenses. The intimate stories behind this triumph lie at the heart of Charles Graeber's The Breakthrough, an expertly crafted and exhilarating account of life-saving ingenuity at its most dazzling. You will never encounter another book so incisive about the art of medical sleuthing, or so poetic about our innate drive to hold on to all that's beautiful in this world for as long as we can." (Brendan I. Koerner, Wired contributing editor and author of The Skies Belong to Us)
"[A] deft, detailed study of cancer immunotherapy.... From the once-discredited pioneer William Coley to immunologist and Nobel laureate James P. Allison, they form a brilliant, driven, admirably stubborn group that Graeber brings vividly to life." (Nature)
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Historia
From the author of The Emperor of All Maladies, winner of the Pulitzer Prize, and The Gene, a #1 New York Times bestseller, comes his most spectacular book yet, an exploration of medicine and our radical new ability to manipulate cells. Rich with Mukherjee’s revelatory and exhilarating stories of scientists, doctors, and the patients whose lives may be saved by their work, The Song of the Cell is the third book in this extraordinary writer’s exploration of what it means to be human.
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Beyond Words Wonderful
- De Lynn en 11-27-22
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Anticancer
- A New Way of Life
- De: David Servan-Schreiber
- Narrado por: Robert Fass
- Duración: 8 h y 54 m
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Historia
The revolutionary New York Times best seller about powerful lifestyle changes that can fight and prevent cancer - an integrative approach based on the latest research.
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Great Book - No PDF :(
- De Rob Strauser en 05-07-20
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For Blood and Money
- Billionaires, Biotech, and the Quest for a Blockbuster Drug
- De: Nathan Vardi
- Narrado por: Rob Shapiro
- Duración: 8 h y 33 m
- Versión completa
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Historia
For Blood and Money tells the little-known story of how an upstart biotechnology company created a one-in-a-million cancer drug and how the core team—denied their share of the profits—went and did it again. In this epic saga of money and science, veteran financial journalist Nathan Vardi explains how the invention of two of the biggest cancer drugs in history became (for their backers) two of the greatest Wall Street bets of all time.
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Must-read for biotech enthusiasts and scientists
- De Anonymous User en 03-16-23
De: Nathan Vardi
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An Elegant Defense
- The Extraordinary New Science of the Immune System: A Tale in Four Lives
- De: Matt Richtel
- Narrado por: Fred Sanders
- Duración: 12 h y 33 m
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Historia
A magnificently reported and soulfully crafted exploration of the human immune system - the key to health and wellness, life and death. An epic, first-of-its-kind audiobook, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize-winning New York Times journalist.
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Weak foundation, good conclusion
- De David en 03-24-19
De: Matt Richtel
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The Emperor of All Maladies
- A Biography of Cancer
- De: Siddhartha Mukherjee
- Narrado por: Fred Sanders
- Duración: 22 h y 18 m
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The Emperor of All Maladies reveals the many faces of an iconic, shape-shifting disease that is the defining plague of our generation. The story of cancer is a story of human ingenuity, resilience, and perseverance but also of hubris, arrogance, paternalism, and misperception, all leveraged against a disease that, just three decades ago, was thought to be easily vanquished in an all-out "war against cancer".
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Incredible
- De S.R.E. en 03-02-16
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Immune
- A Journey into the Mysterious System That Keeps You Alive
- De: Philipp Dettmer
- Narrado por: Steve Taylor
- Duración: 10 h y 28 m
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You wake up and feel a tickle in your throat. Your head hurts. You’re mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door. So what, exactly, is your immune system? In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes listeners on a journey through the fortress of the human body and its defenses.
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Steve Taylor for the win
- De Bay Area Engineer en 11-02-21
De: Philipp Dettmer
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The Song of the Cell
- An Exploration of Medicine and the New Human
- De: Siddhartha Mukherjee
- Narrado por: Dennis Boutsikaris
- Duración: 16 h y 3 m
- Versión completa
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Historia
From the author of The Emperor of All Maladies, winner of the Pulitzer Prize, and The Gene, a #1 New York Times bestseller, comes his most spectacular book yet, an exploration of medicine and our radical new ability to manipulate cells. Rich with Mukherjee’s revelatory and exhilarating stories of scientists, doctors, and the patients whose lives may be saved by their work, The Song of the Cell is the third book in this extraordinary writer’s exploration of what it means to be human.
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Beyond Words Wonderful
- De Lynn en 11-27-22
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Anticancer
- A New Way of Life
- De: David Servan-Schreiber
- Narrado por: Robert Fass
- Duración: 8 h y 54 m
- Versión completa
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General
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Narración:
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Historia
The revolutionary New York Times best seller about powerful lifestyle changes that can fight and prevent cancer - an integrative approach based on the latest research.
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Great Book - No PDF :(
- De Rob Strauser en 05-07-20
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For Blood and Money
- Billionaires, Biotech, and the Quest for a Blockbuster Drug
- De: Nathan Vardi
- Narrado por: Rob Shapiro
- Duración: 8 h y 33 m
- Versión completa
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General
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Narración:
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Historia
For Blood and Money tells the little-known story of how an upstart biotechnology company created a one-in-a-million cancer drug and how the core team—denied their share of the profits—went and did it again. In this epic saga of money and science, veteran financial journalist Nathan Vardi explains how the invention of two of the biggest cancer drugs in history became (for their backers) two of the greatest Wall Street bets of all time.
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Must-read for biotech enthusiasts and scientists
- De Anonymous User en 03-16-23
De: Nathan Vardi
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Tripping Over the Truth
- The Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure
- De: Travis Christofferson
- Narrado por: Clay Lomakayu
- Duración: 9 h y 38 m
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A masterful synchronization of history and cutting-edge science shines new light on humanity's darkest diagnosis. In the wake of the Cancer Genome Atlas project's failure to provide a legible road map to a cure for cancer, science writer Travis Christofferson illuminates a promising blend of old and new perspectives on the disease.
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Non-fiction books - please include references
- De yaelb en 06-15-16
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The Good Nurse
- A True Story of Medicine, Madness, and Murder
- De: Charles Graeber
- Narrado por: Will Collyer
- Duración: 11 h y 35 m
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After his December 2003 arrest, registered nurse Charlie Cullen was quickly dubbed "The Angel of Death" by the media. But Cullen was no mercy killer, nor was he a simple monster. He was a favorite son, husband, beloved father, best friend, and celebrated caregiver. Implicated in the deaths of as many as 300 patients, he was also perhaps the most prolific serial killer in American history.
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The Good Nurse gets it right
- De jc en 05-28-13
De: Charles Graeber
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Random Acts of Medicine
- The Hidden Forces That Sway Doctors, Impact Patients, and Shape Our Health
- De: Anupam B. Jena, Christopher Worsham
- Narrado por: Anupam B. Jena, Christopher Worsham
- Duración: 9 h y 5 m
- Versión completa
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As a University of Chicago–trained economist and Harvard medical school professor and doctor, Anupam Jena is uniquely equipped to answer these questions. And as a critical care doctor at Massachusetts General who researches health care policy, Christopher Worsham confronts their impact on the hospital’s sickest patients. In this singular work of science and medicine, Jena and Worsham show us how medicine really works, and its effect on all of us.
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Podcast is much better
- De R. Weilacher en 08-22-23
De: Anupam B. Jena, y otros
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How to Starve Cancer
- ...And Then Kill It with Ferroptosis
- De: Jane McLelland
- Narrado por: Nano Nagle
- Duración: 11 h y 47 m
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After being given a terminal diagnosis with only a few weeks to live, Jane McLelland dug up research, some decades old, in her quest to survive. Rather than aiming to cure cancer, which in many cases is unachievable, Jane's approach was to stop it growing. Remarkably, her approach not only stopped it growing, it disappeared altogether. There are now clinics following her protocol, achieving remarkable successes.
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Title if NOT accurate, Audio book is of Edition1
- De scott j en 01-21-24
De: Jane McLelland
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The Laws of Medicine
- De: Siddhartha Mukherjee
- Narrado por: Santino Fontana
- Duración: 1 h y 44 m
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Historia
Brimming with fascinating historical details and modern medical wonders, this important audiobook is a fascinating glimpse into the struggles and "eureka!" moments that people outside of the medical profession rarely see. Written with Dr. Mukherjee's signature eloquence and passionate prose, The Laws of Medicine is a critical book not just for those in the medical profession but for everyone who is moved to better understand how their health and well-being are being treated.
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Insightful, sincere and succinct. Not Mukherjee's best.
- De Saurav en 12-20-15
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The Gene
- An Intimate History
- De: Siddhartha Mukherjee
- Narrado por: Dennis Boutsikaris
- Duración: 19 h y 22 m
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Historia
The extraordinary Siddhartha Mukherjee has written a biography of the gene as deft, brilliant, and illuminating as his extraordinarily successful biography of cancer. Weaving science, social history, and personal narrative to tell us the story of one of the most important conceptual breakthroughs of modern times, Mukherjee animates the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.
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It's a Wonderful Book
- De JKC en 06-02-16
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The Cancer Code
- A Revolutionary New Understanding of a Medical Mystery
- De: Dr. Jason Fung
- Narrado por: Brian Nishii
- Duración: 10 h y 48 m
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Historia
Our understanding of cancer is slowly undergoing a revolution, allowing for the development of more effective treatments. For the first time ever, the death rate from cancer is showing a steady decline...but the “War on Cancer” has hardly been won. In The Cancer Code, Dr. Jason Fung offers a revolutionary new understanding of this invasive, often fatal disease - what it is, how it manifests, and why it is so challenging to treat.
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Not helpful for a cancer patient
- De KattyG en 11-25-20
De: Dr. Jason Fung
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Venture Deals, 4th Edition
- Be Smarter than Your Lawyer and Venture Capitalist
- De: Brad Feld, Jason Mendelson
- Narrado por: Barry Abrams
- Duración: 11 h y 4 m
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The founders and driving force behind the Foundry Group - a venture capital firm focused on investing in early-stage information technology companies - Brad and Jason have been involved in hundreds of venture capital financings. Their investments range from small startups to large Series A venture financing rounds. The new edition of Venture Deals continues to show fledgling entrepreneurs the inner-workings of the VC process, from the venture capital term sheet and effective negotiating strategies to the initial seed and the later stages of development.
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Must read for entrepreneurs trying to raise fund
- De Max Lee en 07-29-20
De: Brad Feld, y otros
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Complications
- A Surgeon's Notes on an Imperfect Science
- De: Atul Gawande
- Narrado por: Robert Petkoff
- Duración: 9 h y 31 m
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Sometimes in medicine the only way to know what is truly going on in a patient is to operate, to look inside with one's own eyes. This audio is exploratory surgery on medicine itself, laying bare a science not in its idealized form, but as it actually is - complicated, perplexing, and profoundly human. Atul Gawande offers an unflinching view from the scalpel's edge, where science is ambiguous, information is limited, the stakes are high. In dramatic and revealing stories of patients and doctors, he explores how deadly mistakes occur and why good surgeons go bad.
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FALLIBILITY, MYSTERY AND UNCERTAINTY
- De AnnH en 10-04-20
De: Atul Gawande
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The Song of the Cell
- An Exploration of Medicine and the New Human
- De: Siddhartha Mukherjee
- Narrado por: Abhishek Sharma
- Duración: 18 h y 9 m
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Historia
In the late 1600s, a distinguished English polymath, Robert Hooke, and an eccentric Dutch cloth merchant, Antonie van Leeuwenhoek, look down their handmade microscopes. What they see introduces a radical concept that sweeps through biology and medicine, touching virtually every aspect of the two sciences and altering both forever. It is the fact that complex living organisms are assemblages of tiny self-contained, self-regulating units. Our organs, our physiology, our selves—hearts, blood, brains—are built from these compartments. Hooke christens them 'cells'.
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Boring, tedious, flowery endless stories
- De 964a5 en 12-13-23
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Radical Remission
- Surviving Cancer Against All Odds
- De: Kelly A. Turner
- Narrado por: Kelly A. Turner
- Duración: 9 h y 26 m
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Early in her career, Kelly Turner, PhD, a researcher, lecturer, and counselor in Integrative Oncology, was shocked to discover that no one was studying episodes of radical remission, when people recover against all odds without the help of conventional medicine, or after conventional medicine has failed. She was so fascinated by this kind of remission that she spent eight years travelling through 10 countries to learn what factors that people experiencing this phenomenon encountered.
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Caution. This book is misleading.
- De PMonaco en 04-16-20
De: Kelly A. Turner
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The Code Breaker
- Jennifer Doudna, Gene Editing, and the Future of the Human Race
- De: Walter Isaacson
- Narrado por: Kathe Mazur, Walter Isaacson
- Duración: 16 h y 4 m
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The bestselling author of Leonardo da Vinci and Steve Jobs returns with a “compelling” (The Washington Post) account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
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Except for the author, this book is good!
- De Johan en 03-14-21
De: Walter Isaacson
Lo que los oyentes dicen sobre The Breakthrough
Calificaciones medias de los clientesReseñas - Selecciona las pestañas a continuación para cambiar el origen de las reseñas.
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- George Reid
- 03-03-19
Good intro to immunotherapy
great sequel to The Emperor of All Malidies. Same format great personal stories combined with solid explanations of the underlying science.
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- Bala
- 03-24-23
Starter Story on Immunotherapy
The Breakthrough: Immunotherapy and the Race to Cure Cancer by Charles Graeber is a well-written and informative book that tells the story of the scientific discoveries that have led to the development of immunotherapy, a new form of cancer treatment that is showing great promise. Graeber does an excellent job of explaining the science in a way that is easy to understand, and he also provides a balanced view of the potential benefits and risks of immunotherapy.
One of the strengths of the book is Graeber's ability to tell a compelling story. He profiles a number of patients who have been treated with immunotherapy, and he describes their experiences in vivid detail. This helps the reader to understand the human cost of cancer, and it also makes the science come alive.
Another strength of the book is Graeber's willingness to confront the difficult questions that immunotherapy raises. For example, he discusses the ethical implications of using the immune system to attack healthy cells, and he also raises concerns about the potential for immunotherapy to exacerbate racial disparities in healthcare.
Overall, The Breakthrough is an excellent book that provides a comprehensive overview of the science and history of immunotherapy. It is a must-read for anyone who is interested in cancer treatment or in the future of medicine.
However, there are a few areas where the book could be improved. First, Graeber could have done a better job of explaining the technical aspects of immunotherapy. Some of the concepts he discusses are quite complex, and it would have been helpful if he had provided more detail.
Second, Graeber could have been more balanced in his coverage of the potential benefits and risks of immunotherapy. He tends to focus on the potential benefits, and he does not discuss the risks as extensively. This could give the reader a false impression of the risks of immunotherapy.
Overall, The Breakthrough is an excellent book that provides a comprehensive overview of the science and history of immunotherapy. It is a must-read for anyone who is interested in cancer treatment or in the future of medicine.
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- Jenny
- 10-24-19
Inspiring + Informational Cancer Treatment Stories
I enjoyed listening to the history and science behind cancer research as well as all of the personal stories of struggle and progress. This gives me hope.
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- rafe
- 10-21-22
An excellent introduction for lay people into the world of immunotherapy for cancer treatment
If you enjoy learning about a range of subjects and have a high school level understanding of human biology, you'll find this book relatively easy to digest during the technical sections and all will find something that resonates with them in the stories of the cancer patients.
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- paul cochrane
- 04-11-24
Inspiring and informative
Will Collyer gives a top notch reading to a story, at once inspiring , and yet cautionary and hopeful.
It was also like an immunotherapy primer with a gripping tale.
After all, what is more gripping than real life.
Also my humblest thanks to those who dedicate themselves to finding solutions to this deadly disease!
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- Kari Niles
- 01-21-19
Surprisingly gripping
Take a scientific problem as vexing as cancer, come at it with an age-old yet controversial approach, and turn it over to a talented writer--one who uses simple metaphors to convey the complex, and who sprinkles in references to Jerry Garcia and Cassablanca just to keep you on your toes. The result? A fascinating medical tale that is still taking shape.
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esto le resultó útil a 15 personas
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- Bin Hu
- 12-01-19
A brief update of cancer therapy for the public
This book provides a few stories of successful and failed efforts in curing and managing cancer with immunotherapy. The narrative in the first chapter seems too emotional, almost like fiction, But later chapters turned out to be better. The book is easy to follow even for a layman and may be of interest to anyone who wants to follow the latest development of treating cancer.
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- Roy Jones
- 04-15-24
Current research on immunotherapy
chapter 1 had too many metaphors, like a dime store crime novel, and the turn to religion seems a slap in the face of the science developed to treat cancer
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- Tim S
- 08-20-19
Excellent
I read this after reading "The Emperor of all Maladies" It's an awesome add on. Well researched, written in an engaging way that keeps the listener locked in, but you will also learn a TON! I love books like this!
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- Merry Rogers
- 06-21-21
Well done
Well told story. The human side as well as the “breakthroughs.” I dislike any book on science which is dumbed down, personalized to opinion, or lacking data and source. This is not one of those.
Excellent.
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