• E23 - Part 2: Timing of caloric restriction for longevity with Victoria Acosta-Rodriguez

  • Sep 27 2024
  • Length: 1 hr and 10 mins
  • Podcast

E23 - Part 2: Timing of caloric restriction for longevity with Victoria Acosta-Rodriguez

Listen for free

View show details

  • Summary

  • After discussing in the first part how caloric restriction can extend lifespan, Dr. Victoria Acosta-Rodriguez (Leader of the Circadian Biology of Aging Unit at the National Institute on Aging (NIA), USA) talks in the second part about her recent study showing that eating these reduced calories always at a certain time of day extends the lifespan of mice even more. Beyond longevity, her study reveals that enhanced health benefits are achieved when feeding versus fasting times are aligned with the natural active and rest phase of mice as dictated by circadian clocks. In the end, we discuss the feasibility of long-term caloric restriction for humans and if similar health benefits could be expected in humans. Chapters: (00:00:45) Recap Part 1 (00:01:28) Part 2 topics (00:02:09) Interview start (00:03:28) Explaining the study design (00:10:01) What kind of food did mice eat and why? (00:13:56) Body weight changes over the lifespan (00:15:58) Relevance of fasting duration (00:19:45) A calorie is a calorie? (00:22:47) The longest-lived mice (00:25:49) Cause of death for 300 mice (00:29:46) Physical activity as a survival predictor (00:31:56) Body composition & metabolic health (00:35:55) 48-hour liver samples (00:47:18) Study limitations (00:51:59) Monkey studies (00:55:16) Feasibility of caloric restriction for humans (00:59:21) Personal perspective (01:09:00) Outro Main study that we will discuss in depth: Acosta-Rodriguez, V., Rijo-Ferreira, F., Izumo, M., Xu, P., Wight-Carter, M., Green, C.B., and Takahashi, J.S. (2022). Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice. Science 376, 1192-1202. 10.1126/science.abk0297. Additional papers that Victoria refers to: Rhesus Monkeys - Caloric restriction & Lifespan Mattison, J. A. et al. Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 489, 318–321 (2012). Colman, R. J. et al. Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nat. Commun. 5, 3557 (2014). Mattison, J. A. et al. Caloric restriction improves health and survival of rhesus monkeys. Nat. Commun. 8, 14063 (2017). Humans -TRF Sutton, E.F., Beyl, R., Early, K.S., Cefalu, W.T., Ravussin, E., and Peterson, C.M. (2018). Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. Cell Metab 27, 1212-1221 e1213. 10.1016/j.cmet.2018.04.010. Humans - CALERIE study Martin, C. K. et al. Effect of calorie restriction on mood, quality of life, sleep, and sexual function in healthy nonobese adults: the CALERIE 2 randomized clinical trial. JAMA Intern. Med. 176, 743–752 (2016). Das, S. K. et al. Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-year randomized controlled trial of calorie restriction in nonobese humans. Am. J. Clin. Nutr. 105, 913–927 (2017). Mice – NIA Intervention Testing Program https://www.nia.nih.gov/research/dab/interventions-testing-program-itp Francesca Macchiarini, Richard A. Miller, Randy Strong, Nadia Rosenthal, David E. Harrison, Chapter 10 - NIA Interventions Testing Program: A collaborative approach for investigating interventions to promote healthy aging, In Handbooks of Aging, Handbook of the Biology of Aging (Ninth Edition), Academic Press, 2021, Pages 219-235, ISBN 9780128159620, https://doi.org/10.1016/B978-0-12-815962-0.00010-X Contact: Dr. Victoria Acosta-Rodriguez Email: victoria.acosta-rodriguez@nih.gov Twitter/X: @VickyAcostaR
    Show more Show less
Show more Show less

What listeners say about E23 - Part 2: Timing of caloric restriction for longevity with Victoria Acosta-Rodriguez

Average customer ratings

Reviews - Please select the tabs below to change the source of reviews.

Audible.com reviews

Amazon reviews
No Reviews are Available