Linda Schatz, Director of AKASA, explains the role of Clinical Documentation Integrity (CDI) specialists in ensuring accurate coding and bridging the gap between clinical documentation and specific, accurate codes to ensure proper reimbursement. The complexity of medical coding often leads to errors, which can be nearly eliminated by using AI to review 100% of patient encounters to identify inconsistencies and help CDI and coding professionals process more accurate claims quickly. Accurate documentation is important for hospital revenue, patient care quality, and perception of the hospital's performance.

Linda explains, "Well, the old adage, if it isn't documented, it wasn't done. If the doctor uses incorrect or perfectly acceptable medical terminology, it doesn't translate into an appropriate code. You've heard the term UIs, this is years ago, right? Grandma had UTIs and died. In the coding world, that used to code for a simple UTI. So the hospitals are getting paid for a patient that took care of a UTI, when in reality that patient was septic. To the outside world, it looks like Grandma came to the hospital, something that could have been treated outpatient, and she died. So the public perception of quality is less. So not only is it revenue, it's quality, but ultimately it's delivering patient care."

"I'm an old nurse. I've been in this field for over 40 years. I've worked across the NICU, PICU, and adult ICU. I've worked in access hospitals to large academics and all the way through hospice. That's pretty unique as a nurse to have that big of a background. Then I became a CDS, or clinical documentation specialist, or integrity specialist, and learned the documentation and coding aspect."

"Then I moved into the consulting role and worked with organizations and physicians all across this nation, helping them learn how to do this. And so you've got the clinical background, the coding background, and now I understand how generative AI works. And so while you're a new nurse, you're a horse, right? When we hear a heartbeat, we think of a horse, and after years, you earn your stripes and you become a zebra, and then you add all of these multiple areas of expertise, you become uniquely valuable as a pink zebra."

#AKASA #GenAI #CDI #RevenueCycleManagement

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Tina Liedtky, President of Transplant Diagnostics at Thermo Fisher Scientific, identifies the significant challenges in the US organ transplant system that must be addressed to meet the demand for organs. Patient access to transplant care is hindered by geography, the need to match donors and recipients, and the threat of organ rejection. Living donations, particularly of kidneys and livers, are a solution to address the organ shortage, as organs from living donors often lead to better outcomes and can be scheduled to avoid damage caused by organ transportation.

Tina explains, "So first of all, I would say that organ transplantation saves thousands of lives a year and gives patients with end-stage organ disease the ability to extend their lives meaningfully for many years. However, the organ transplant system in the US is not perfect, and it faces several real challenges. The most pressing challenge is a persistent imbalance between organ supply and demand, in that far more patients are in need of a lifesaving transplant than there are available organs, which leaves many patients waiting too long for a compatible organ or perhaps will never receive a compatible match. And unfortunately, for those patients left waiting, many get sicker, and often patients die while waiting on the wait list. So this gap in supply and demand is real, and it underscores the importance of living donation, which can help expand the pool of available organs and give patients a chance at the timely care that they need."

"Another significant challenge is patient access to organ transplant care. For instance, in the weeks leading up to the transplant procedure and after the procedure, patients are often required to be living or situated near the hospital or the transplant center where the surgery is performed. This can pose a challenge to those who simply don't reside in areas where there are major transplant centers or who can't afford temporary housing. And that creates a socioeconomic inequity when it comes to access."

#ThermoFisherScientific #Transplantation #OrganDonors #LivingDonation #HeartTransplant #OrganTransplants

thermofisher.com

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Dr. Sev MacLaughlin, the CEO of DeLorean AI, has developed an AI platform to identify at-risk patients, including those with renal disease, cardiovascular disease, and mental health conditions. Serving smaller and mid-sized provider clinics, this approach supports the shift to value-based care by predicting adverse events, recommending preventive measures, and reducing hospitalizations and healthcare costs. By analyzing entire populations instead of samples, the platform avoids biases and overlooked subgroups inherent in traditional analytical methods.

Sev explains, "So I think there's an opportunity to not only give better care at the point of care, but also aid in the discovery or assist in the diagnosis of unknown diseases that people may have in the chronic format. That may be identifying chronic kidney disease patients five years earlier, so they can have a different treatment modality and directionality in their lives, or hypertension or cardiovascular disease."

"We're very strong in renal. So both chronic kidney disease and end-stage renal failure, or patients on dialysis. And then the two comorbidities that most that are huge influences for that are cardiovascular disease, cardiovascular system, and diabetes. In addition to that, we do CD and pulmonary. And then we were asked by one of our largest clients, United Healthcare, to look at mental health. And I have to say another surprise to me is how important mental health is to the other disease states, so that mental health needs to be taken care of to ensure that those individuals are medically adherent, they're going to their appointments, they're taking their medications, they're taking their health seriously. And that is something that I learned was most important and needed to be treated in parallel with the primary care diagnosis."

#DeLoreanAI #PreventativeCare #RenalCare #MedAI #Diagnostics #PopulationHealth #RiskStratification

DeLoreanai.com

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Antoine Pivron, Vice President of Health Solutions in the B2B division at Withings, highlights the clinical-grade connected devices that are changing the remote patient monitoring market. The equipment and AI-enhanced tools are designed to focus on personalized patient engagement and retention, ultimately leading to improved health outcomes. The data made available identifies trends over time, allowing for intervention when necessary, and is presented in a form that emphasizes prevention rather than reaction.

Antoine explains, "We are very well known for our connected devices, especially the weight scales. So we were the first company back in 2009 to develop a connected weight scale, and now we are the leader in this field, mainly in Europe and in the US. So I think we might have the broadest ecosystem of connected devices to be honest, on the market. So we have weight scales, but we also have blood pressure monitors, activity trackers with smart watches. We also have urine analyzers that we're going to launch next week, actually. We really do have a huge range of products that can be used at home to remotely monitor patients."

"They're actually analyzing the trends over weeks, months, and they have an intervention when there is something that is not going in the right direction. So it's more about managing alerts if needed. For instance, in chronic heart failure, most remote patient monitoring programs, doctors manage alerts only. And for obesity care, it might be like coaches or nutritionists having a one-time a week or a one-time a month video call with the patient, and they're just managing the trends. So it's not about being in constant alert, it's about having more data to help them make the right decision."

#Withings #DigitalHealth #RemoteMonitoring #ConnectedDevices #MedTech

withings.com

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Dr. Jay Lalezari, CEO of CytoDyn, is focused on solid tumor immunology, particularly in triple-negative breast cancer, where their lead drug, leronlimab, is showing significant long-term survival benefits. This monoclonal antibody targets the CCR5 receptor, converting cold tumors into hot tumors and making them more susceptible to immunotherapy checkpoint inhibitors. Work with leronlimab for 20 years has demonstrated the potential for use in colorectal cancer as well as TNBC, and to vastly expand the patient population that could benefit from immunotherapy.

Jay explains, "When I became CEO back in November of 2023, my first order of business was to figure out where CytoDyn should go with this intriguing monoclonal antibody called leronlimab that targets CCR5. And we looked at a number of indications, and by far and away, the data that we found in solid tumor oncology is clearly the place CytoDyn will go to create the most benefit for patients and the most benefit for our shareholders. We recently presented some data in triple-negative breast cancer that is truly remarkable and potentially paradigm-shifting in the world of solid tumor oncology."

"Over the years, it became clear that CCR5 was not just for the virus to get inside the cell, but was playing a key role in setting up the tumor microenvironment in a variety of solid tumors that were CCR5 positive. That included typically triple-negative breast cancer, colon cancer, prostate cancer, pancreatic cancer, sarcoma, glioblastoma, and the urothelial cancers in particular. So CCR5 helps the cancer set up a tumor microenvironment that helps it both build blood vessels to provide nourishment for the cancer and attract suppressor cells that keep the host immune system at bay."

#CytoDyn #Oncology #Leronlimab #TNBC #ColorectalCancer #CCR5

cytodyn.com

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Andrew Rosen, Chief Executive Officer of the National Ataxia Foundation, has a dual mission of accelerating research for treatments and cures for Ataxia while supporting the patients affected by this rare disease. Ataxia describes both a group of hereditary genetic diseases and symptoms of lack of coordination seen in other conditions. While genetic tests exist for hereditary Ataxia, a significant challenge in drug development has been the lack of a reliable biomarker. To encourage drug development, NAF has funded translational research and the world's most extensive study for SCAs, Spinocerebellar Ataxias, providing new data on the progression of the disease and for the design of future trials.

Andrew explains, "NAF has been around for a long time. We were founded in the late 1950s by a neurologist in western Minnesota who had a disease called Ataxia in his family. And NAF's mission has really been twofold ever since that. Our formal statement is that we are trying to accelerate the development of treatments and a cure while working to improve the lives of those living with Ataxia. And so we really focus on research and support. We do a lot in the research world. We fund grants for researchers who are looking into the various types of Ataxia. You'd be hard pressed to find an Ataxia researcher in the world, I think I can say now at this point that hasn't received a grant from NAF at one time or another in their career. We also do a lot of translational-type research. We fund the largest natural history study in Ataxias."

"So, the term ataxia itself is even complex because it both describes a genetic disease, and I think of that as capital 'A' - Ataxia, but it's also a symptom of many other conditions. So small 'a', if you will. Ataxia just means a lack of coordination. It comes from a Greek word. And so what I mean by both hereditary and other things is if you, for instance, have too much to drink, you would show signs of Ataxia. You might stumble when you walk, and your speech might be slurred. Those are the two classic symptoms of hereditary Ataxia. Right. So that's really the Ataxias that we at NAF focus on. So hereditary, as in passed from parent to child, there are several hundred forms of hereditary Ataxia, and they continue to find more as more specific genetic mutations are discovered year after year now."

#NationalAtaxiaFoundation #Ataxia #PatientAdvocacy #RareDisease #SCA

ataxia.org

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Anne Meneghetti, Executive Director of epocrates, is focused on medication management and providing tools for clinicians to better handle challenges from the increasing population of patients who take multiple drugs and are treating a wide variety of conditions. The epocrates app provides access to drug information, pill identification, checks for interactions, and calculates dosing, reducing medication errors and patient confusion. Polypharmacy patients are further at risk when they are taking over-the-counter drugs and supplements, requiring regular medication reconcilation to avoid serious drug interactions.

Anne explains, "So epocrates has been around since the late 1990s, and it's the number one mobile medical app in the country in terms of physician usership. And it's both a free model and a subscription model. The main reason why clinicians use epocrates is because of the drug information. So, quickly looking up a drug dose, for example, if a drug needs to be prescribed by weight, what is the calculation for that? And there's no way that clinicians can memorize 8,000 drugs. So having it in a quick, easy-to-use app is really crucial in modern times. And sometimes it's not that the clinician doesn't know the dose of the drug, it's just that validation. When you pick up an app and look and see, yep, that's what I thought it was. And that validation, that sense of confidence, is something really precious for a busy clinician. We also use it for drug interactions."

"We find that clinicians really value drug interactions because you can't memorize 8,000 drugs interacting with 8,000 other drugs. And your EHR might tell you if you're trying to prescribe two drugs at the same time, your EHR might tell you, oh, red light, green light, yellow light. But a really good drug reference, like epocrates can tell you, if you're going to prescribe these two drugs together, you need to cut the dose of this one in half and you need to monitor the potassium levels. We find that clinicians really value drug interactions because you can't memorize 8,000 drugs interacting with 8,000 other drugs. And your EHR might tell you if you're trying to prescribe two drugs at the same time, your EHR might tell you, oh, red light, green light, yellow light. But a really good drug reference, like epocrates can tell you, if you're going to prescribe these two drugs together, you need to cut the dose of this one in half and you need to monitor the potassium levels."

#epocrates #MedicationManagement #Polypharmacy #DrugInteractions #DigitalHealth

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Dr. Adam Kilian, Director of the Rheumatology Fellowship Training Program at the St. Louis University School of Medicine, focuses on IgG4-related disease, a rare multi-organ disease that has only recently been recognized due to significant diagnostic challenges. The MITIGATE trial is a landmark study that demonstrated that the first FDA-approved treatment, UPLIZNA from Amgen, provides an effective, targeted, steroid-free therapy. The approval of this drug is driving awareness in the medical community about IgG4-RD and whether the disease should be considered after inconclusive results for other suspected conditions.

Adam explains, "IgG4-related disease is a rare disease that affects many organ systems. It's a chronic systemic, fibroinflammatory disease that can affect almost any organ system. And it will usually present with these tumor-like inflammatory masses that can cause scarring and lead to organ failure."

"Our understanding of it continues to evolve, and it's had a really interesting story over the last century because IgG4-related disease affects so many different organ systems. Over the past century, there were actually many different diagnoses that were recognized, which now all fall under the umbrella of IgG4-related disease. Different scientists and physicians around the world over the years recognized the different manifestations of the disease in the pancreas, in the lymph nodes, in the head and neck, in the kidneys, or in the blood vessels. And it's only been in the last 20 years or so that we have recognized that actually all of these different disease entities from the last century are actually all manifestations of this disease, IgG4, IgG4-related disease."

"The clinical trial is called the MITIGATE trial, and it's a very seminal clinical trial in rheumatology from the last several years. This was the first-ever phase three double-blind, placebo-controlled, randomized controlled trial in IgG4-related disease. This was a huge trial. It was global. It was conducted in 22 countries with multiple specialties coordinating this trial. It was 52 weeks long, and its purpose was to evaluate the effectiveness and the safety of UPLIZNA in patients who have IgG4-related disease."

#MITIGATETrial #IgG4RelatedDisease #IgG4RD #UPLIZNA

UPLIZNA

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