Much of what we read online about horse health is misleading. So, for those of you following a more natural and holistic path by focusing on the diet, lifestyle, and environment of your horses before turning to drugs or surgery, having the correct understanding is essential. I hope that each episode helps you view conditions like insulin resistance, equine metabolic syndrome, and laminitis with clearer eyes and more confidence.

Today, we are exploring insulin, what happens when it stays high for too long, why it becomes toxic in the body, and how this links to metabolic dysfunction, chronic inflammation, and the early stages of laminitis.

Insulin Can Become Toxic

When insulin remains elevated for too long, it starts to act like a toxin. It constricts blood vessels, increases inflammation, damages cells, and impairs nutrient delivery, especially to their highly sensitive hooves.

Inflammation and Insulin Feed Each Other

High insulin drives inflammation. Inflammation drives insulin levels even higher, damaging tissues, reducing circulation, and increasing the likelihood of laminitis. Breaking this cycle requires addressing both inflammation and insulin simultaneously.

The Role of Nutrition and Detox

Supporting your horse with proper nutrition and removing toxins is essential. Antioxidants, clean feed, and reducing chemical exposures will help the body repair damaged cells, restore balance, and bring insulin levels back into a healthy range.

Hoof Health Depends on Circulation

Hoof care and internal health must go hand in hand. Restricted blood flow in the hooves worsens laminitis and founder. Proper trimming, padding, booting, and movement are all critical, along with dietary and metabolic support.

The Whole Body Matters

If symptoms are visible in the feet, the rest of the body will be affected as well. Supporting liver function, reducing stressors, and regenerating cells throughout the body improves overall health and helps prevent further complications.

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Last week, we explored the early signs of toxicity in horses. Today, we revisit a previous episode to clarify what toxicity is and how it affects your horse.

Toxicity is one of the leading causes of equine disease. When the toxic load of horses exceeds what they can process, it becomes hard for their tissues to remain healthy, their organs to function as they should, and their body systems to work together to sustain good health.

Today, I scratch the surface of the vast and complex topic of toxicity, giving you a little food for thought. Since this is a massive subject, I will likely revisit it and dive deeper into some of the points we cover today in future episodes.

Understanding Toxicity in Horses

Toxicity refers to the degree to which a substance can harm cells, tissues, organs, or entire systems. For horses, toxicity often accumulates gradually, influencing their health over time. Genetic makeup, nutrition, and environmental exposure are all factors that determine how well a horse can handle toxins. Well-nourished horses with good constitutions and minimal exposure to harmful substances are generally more resilient. Yet they can also struggle as they age, particularly between 14 and 16 years, when signs of imbalance often emerge.

Early Signs of Toxicity

The initial effects of toxicity can be subtle and easy to overlook. A horse may develop a dull coat, cracked hooves, or irregular shedding patterns. Some subtler changes, such as stiffness, swelling, joint discomfort, a weakened immune system, or slow recovery from illness, could also indicate that the body struggles to handle its toxic load.

Key Sources of Toxicity

• Environmental chemicals in feed, hay, and water
• Fertilizers, preservatives, and additives
• Pathogens, like bacteria, viruses, and parasites

Dietary imbalances

Dietary imbalances are another major factor contributing to poor equine health. Excess sugar or protein can stress the body and lead to inflammation, metabolic issues, and poor gut health, and a diet heavy in oils can disrupt the gut microbiome.

Acidity

Acidity in the body often results from an imbalanced diet, leading to conditions like leaky gut, systemic inflammation, and joint issues. Hormonal imbalances, such as prolonged high cortisol or insulin levels, also cause significant damage over time, contributing to tissue breakdown, laminitis, and immune dysfunction.

Antioxidants

Antioxidants are crucial for combating free radicals, the unstable molecules that damage cells and DNA. Free radicals naturally occur during metabolic processes, but increase with high toxic loads. Without sufficient antioxidants to neutralize them, free radicals can accelerate aging, weaken the immune system, and cause long-term damage.

The Cumulative Effect of Toxicity

Even though toxins seldom cause immediate harm, they accumulate over time. A horse that has consumed feed with additives, dealt with multiple infections, or been on long-term medications may eventually show signs of toxicity. The cumulative effect often leads to nutritional deficiencies, compromised immunity, and declining health.

Strategies for Reducing Toxicity

• Eliminate unnecessary supplements and observe how the horse responds to a more natural diet.
• Prioritize high-quality feeds and hay with minimal additives, and avoid excessive sugar, protein, or oils, as they can disrupt metabolic health and the gut microbiome in horses.
• Address pathogens and infections promptly.
• Support detoxification with bioavailable nutrients to restore reserves and help the body manage its toxic load effectively.

Final Thoughts

Toxicity develops slowly. Understanding

We’re talking about toxicity today.

I’ve been seeing several cases lately where toxicity plays a role, so I thought it was time to revisit the topic. In episode 53, I covered the definition of toxicity and what it means for your horse, so you can go back and listen to it after this episode for more details.

Stay tuned as I share the signs to look out for.

Understanding Toxicity in Horses

Toxicity in horses often develops slowly and subtly through accumulated exposure to feed contaminants, environmental chemicals, medications, or poor-quality diets. Unlike sudden poisoning, this buildup can take years to show outwardly. Younger horses may appear healthy despite ongoing exposure, but as they age, resilience drops and health issues surface, usually from around age 12 onward.

Early Warning Signs

Subtle behavioral and physical changes often signal toxicity. These can include fatigue, dull eyes, reduced social engagement, depression, or anxiety. Appetite changes are also key clues- horses that suddenly become picky or disinterested in food may be reacting to gut irritation or inflammation. Paying attention to these small shifts helps catch toxicity before it escalates.

Behavior and the Nervous System

Toxicity can impact the nervous system, leading to high anxiety and nervousness. While horsemanship helps build horses’ confidence, chronic anxiety can point to underlying health issues or an internal imbalance. Ulcers and overactive immunity often accompany this state, as pain and inflammation trigger more stress in a self-perpetuating cycle.

Inflammation

Inflammation is one of the most common consequences of toxicity. It often presents as laminitis or joint stiffness, even when blood work looks normal. Laminitis is particularly revealing as hoof tissues react early to systemic inflammation. Many arthritic horses may actually be struggling with toxic buildup rather than structural degeneration, and they often improve after detoxification.

The Liver

The liver detoxifies all chemicals entering the body, but chronic overload eventually leads to fatigue and dysfunction. As detoxification slows, toxins accumulate, affecting hormone balance, immune strength, and overall vitality. So, even when liver enzymes appear normal, the liver may still be under strain.

The Gut–Toxicity Connection

Gut health is often the first to suffer. Long-term exposure to irritants, sugars, or intolerant feeds leads to inflammation, leaky gut, and cecal acidosis. A damaged intestinal lining allows toxins to circulate through the body, causing hives, laminitis, or chronic infections. Gut inflammation also prevents nutrient absorption.

Nutrient Deficiency

Toxicity compounds over time. Horses with chronic gut irritation or sugar-heavy diets often experience nutrient depletion because their inflamed intestines cannot absorb key minerals and vitamins.

Common Physical Signs

Visible indicators include dull or coarse coats, cracking or separating hooves, weepy eyes (often linked to liver dysfunction), nasal discharge, and reduced energy. These may seem mild or age-related, but they could reflect systemic imbalance from long-term toxicity.

Reversing the Effects

Improvement begins with removing toxins from feed, water, and the environment. Cleaning up the diet allows the liver, kidneys, and gut to recover. Even older horses can regain their vitality after reducing their toxicity and with good nutrition.

Long-Term Prevention

Reducing toxicity is one of the most effective ways to prevent disease. By being mindful of feed quality, ingredient lists, and exposure sources, owners can dramatically improve their horses’ health spans and overall...