Oral nicotine pouches are becoming more popular in the US, based on a survey performed in 2022. Hongying Daisy Dai, PhD, from Nebraska Medical Center, Omaha, discusses nicotine pouches and more with JAMA Deputy Editor Kristin L. Walter, MD, MS.

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• Prevalence of Nicotine Pouch Use Among US Adults

Availability of pediatric care is decreasing, despite the growing complexity of pediatric care needs. Match rates for pediatric residency continue to decline. The US risks a serious shortage of pediatricians. Julie Byerley, MD, MPH, executive vice president & chief academic officer, Geisinger, Pennsylvania, discusses this and more with JAMA Deputy Editor Linda Brubaker, MD, MS.

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• Where Are All the Pediatricians?

Facilitating safe and timely health care for individuals planning medication abortion is a reproductive health care priority. Lauren J. Ralph, PhD, MPH, and Daniel Grossman, MD, of University of California San Francisco join JAMA Deputy Editor Linda Brubaker, MD, MS, to discuss Comparison of Effectiveness of No-Test Telehealth and In-Person Medication Abortion.

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• Comparison of No-Test Telehealth and In-Person Medication Abortion

Can a new ECG finding identify individuals at risk for dying suddenly? Jason D. Roberts, MD, of McMaster University joins JAMA Associate Editor Gregory M. Marcus, MD, MAS, to discuss A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome (CRDS). CRDS is a recently described cause of sudden arrhythmic death. Until now, no clinical test has existed to identify those with the disease.

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• A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome
• The First Clinical Test for Calcium Release Deficiency Syndrome?

Joel M. Dulhunty, MD, PhD, Royal Brisbane and Women’s Hospital, and Jason A. Roberts, BPharm, PhD, University of Queensland Centre for Clinical Research, join JAMA Deputy Editor Preeti Malani, MD, MSJ, to discuss the BLING trial that assessed continuous vs intermittent β-lactam antibiotic infusions in patients with sepsis or septic shock.

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• Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis
• Prolonged vs Intermittent Infusions of β-Lactam Antibiotics in Adults With Sepsis or Septic Shock

Randomized clinical trials (RCTs) frequently fail to generate knowledge relevant to practice, while practice patterns are frequently unsupported by RCT evidence. Derek C. Angus, MD, MPH, of the University of Pittsburgh, joins JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss The Integration of Clinical Trials With the Practice of Medicine: Repairing a House Divided.

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• The Integration of Clinical Trials With the Practice of Medicine

Forced nitrogen inhalation was used by the state of Alabama to execute Kenneth Smith on January 25, 2024. Some politicians, attorneys general, and health care practitioners support its use for capital punishment in the US. Philip E. Bickler, MD, PhD, and Michael S. Lipnick, MD, discuss the evidence indicating that forced nitrogen inhalation is inhumane with JAMA Executive Editor Gregory Curfman, MD.

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• Evidence Against Use of Nitrogen for the Death Penalty

Guidelines call for better evidence on the health outcomes after living kidney donation. Author Amit X. Garg, MD, PhD, London Health Sciences Centre, and editorialist Elizabeth C. Lorenz, MD, Baylor College of Medicine, discuss a new study that compares the risks of hypertension and other health outcomes in living kidney donors, with JAMA Associate Editor Wolfgang Winkelmayer, MD, ScD.

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• Hypertension and Kidney Function After Living Kidney Donation
• Prospectively Examining Outcomes After Living Kidney Donation
• Kidney Transplant Outcomes From Deceased Donors Who Received Dialysis
• Expanding the Overton Window in Deceased Kidney Donor Eligibility—Enough to Make a Difference?