1:05 -  Nathan’s love for physics & his background in nuclear

12:37 - What is the purpose of science and technology?  

19:36 - Nathans mental models for longevity 

34:49 - What’s missing in longevity? 

48:43 - Who is bearing the cost of humans growing old and getting sick?

51:57 - A touching story with Nathan’s grandparents 

56:09 - Publics’s distaste for aging - people don’t wanna think about getting old

1:00:06 - Can we extent life today, or do we need more data?

1:09:57 - Optimism for the future of longevity technology   

0:29 -  Almost getting a Ph.D., getting sucked into capitalism

6:12 - Research at Harvard & MIT Broad Institute

10:46 - Finding ones identity within Science

21:37 - Josh’s 1st startup, EdTech, Inkling

33:32 - Getting a $7M term sheet from Sequoia in grad school

38:05 - Is Silicon Valley just a hype machine?

42:24 - How science is supposed to work

48:09 - James rants on what he loves about science and startups

52:40 - A lack of diversity in silicon valley

58:35 - Unique Dynamism of America

1:07:01 - Web3 & new money for science

1:18:06 - Where are the nerds focused on right now? Climate, deep tech, ai

1:23:02 - Understanding crypto walkthrough - the a ha moment - high level

1:38:29 - What can you do with Web3 - Josh’s new startup - Pharma

1:50:59 - How to connect with Josh and keep up with VibeBio

(0:38) -  Intro to Mike, SiPhox, chips, and biosensing. 

(14:04) - Theranos

(16:36) - First-principles of how SiPhox detects biology using silicon photonics. 

(26:51) - How does the world look in 5 years if SiPhox continues to innovate at its current pace?

(36:62) - Measuring aging and detecting inflammation

(43:33) - The “holy grail” measurement for biosensing 

(55:50) - History of Silicon Chips and the Photonics industry - “chip playground” 

(59:51) - Why it’s still early and Mike’s outlook for the future

(1:08:08) - Mike’s 1st startup in Undergrad

(1:12:38) - Quantum and Photonic Bitcoin (PoWx) & Libertarianism 

(1:33:28) - Building a COVID biosensor mid pandemic in YCombinator

(1:57:02) - Mike’s advice for startup founders

(2:12:22) - Software vs Hardware startup tradeoffs

(2:16:25) - Building his lab from scratch+