Jeff and Rob both love performing drama AND comedy! Jeff Daniels joins Rob Lowe to discuss how working with Jim Carrey on “Dumb and Dumber” taught him fearlessness, committing to his thick accent in Netflix’s “A Man in Full,” his memories of the brilliant James Gandolfini, their experiences performing Aaron Sorkin dialogue, watching Shirley MacLaine and Debra Winger's process on "Terms of Endearment,” and why Jeff settled down in Michigan.

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Rob is entering his 60s and committing to a better diet…with the help of the esteemed Dr. Mark Hyman! Dr. Mark Hyman (renowned physician, medical advisor to the Clintons, and the host of “The Doctor's Farmacy” podcast) joins Rob Lowe to discuss the Ozempic revolution, the real key to longevity, the obesity statistic that shocked Rob, what foods to avoid, and the easy-to-find snacks that just might help you live longer.

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Comedian, actor, and podcaster Paul Scheer joins Rob Lowe to discuss celebrity-owned restaurants, the “M*A*S*H” theme song, why the team behind “The League” decided to end the show while they were still on top, Rob’s traumatic childhood talent show memory, the greatest audition story ever, and Paul’s new memoir, “Joyful Recollections of Trauma.” Pre-order “Joyful Recollections of Trauma” now - out May 21st!

Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

Kelly Ripa joins Rob Lowe to discuss getting “knighted” by Disney, the joys of working with her husband, why Rob was one of Kelly’s favorite guest co-hosts, trying out the Oculus headset, Rob’s 60th birthday party, her podcast “Let's Talk Off Camera with Kelly Ripa,” and her big goal to get out of hair and makeup!

Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

Katey and Rob looooove talking to other sober people! Actress and musician Katey Sagal joins Rob Lowe to discuss her new podcast with husband Kurt Sutter, the joys of sobriety, the passing of her godfather Norman Lear, being a Keith Richards girl, working with the amazing John Ritter, why “Sons of Anarchy” convinced Rob to go buy a biker jacket, being of service, and much more.

Listen to Katey’s new podcast, “PIE with Kurt Sutter and Katey Sagal!” Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

Tig and Rob are silent laughers. Comedian Tig Notaro joins Rob Lowe to discuss their shared obsession with the song “Do They Know It’s Christmas?” by Band Aid, her foolproof method for testing potential TV show titles, her love for drama and despair, her podcast “Handsome,” and her new comedy special, “Hello Again.” Plus, Rob reveals a bit of White House trivia he learned shooting “The West Wing.”

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Rob is a huge admirer of the incredible activist and R&B musician Daryl Davis. He is the first Black author to write a book on the Ku Klux Klan (KKK) based on in-person interviews, and he has convinced dozens of Klansmen to leave and denounce the hate group. Today, Daryl joins Rob to discuss his incredible activism work, the power of conversation, his experiences meeting with the KKK as a Black man, and playing with legends like Chuck Berry and B.B. King.

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Rob Lowe and Ted Sarandos love to quote their favorite movies together! Co-CEO of Netflix (and film fanatic) Ted Sarandos joins Rob Lowe to discuss his early days as a video store manager in Arizona, the little-seen Netflix comedy series that he is obsessed with, how the Netflix algorithm and his own fandom led to the company’s deal with Adam Sandler, what AI could mean for the entertainment industry, and much more. Plus, Rob shares one of his favorite golf memories!

Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!