This is the second of a two-part series of episodes about Paediatric Long Haulers. Dr Danilo Buonsenso is a is a Physician-Scientist and a specialist in Infectious Diseases in children. He talks with Dr Funmi Okunola MD about how to diagnose and manage children with Long COVID.

Dr. Buonsenso currently works at the Department of Women, Child and Public Health at the Gemelli University Hospital in Rome, Italy.

Research Articles and Links:

1. Bygdell M, Kindblom JM, Martikainen J, Li H, Nyberg F. Incidence and characteristics in children with post–COVID-19 condition in Sweden. JAMA Network Open. 2023 Jul3;6(7):e2324246-.

2.Buonsenso & the Kids

3.Long COVID Kids

4.IP4C - Brackel CL, Noij LC, Vijverberg SJ, Legghe CL, Maitland-van der Zee AH, Van Goudoever JB, Buonsenso D, Munblit D, Sigfrid L, McFarland S, Anmyr L. International Care programs for Pediatric Post-COVID Condition (Long COVID) and the way forward. Pediatric research. 2024 Jan 29:1-6.

In this episode Dr Danilo Buonsenso explains the underlying mechanisms of Long COVID in children.

Dr Danilo Buonsenso MD Phd is a Paediatric Infectious Disease Specialist and Physician Scientist who currently works at the Department of Woman, Child and Public Health at the Gemelli University Hospital in Rome. He has a PhD in Public Health and Biomolecular Sciences and is currently doing his MSc in Infectious Disease at Oxford University.

References

1. The WHO definition of Post-COVID condition in children.

2. Bygdell M, Kindblom JM, Martikainen J, Li H, Nyberg F. Incidence and characteristics in children with post–COVID-19 condition in Sweden. JAMA Network Open. 2023 Jul 3;6(7):e2324246-.

3. Thors V, Bjornsdottir KL, Love TJ, Haraldsson A. Long COVID in Icelandic Children: A Matched Cohort Study of Nonspecific Symptoms Following SARS-CoV-2 Infection. The Pediatric InfectiousDisease Journal. 2024 Mar 1;43(3):226-33. (behind a paywall)

4. Delogu AB, Aliberti C, Birritella L, De Rosa G, De Rose C, Morello R, Cambise N, Marino AG, Belmusto A, Tinti L, Di Renzo A. Autonomic cardiac function in children and adolescents with long COVID: a case-controlled study. European Journal of Pediatrics. 2

5. BaldiF, De Rose C, Mariani F, Morello R, Raffaelli F, Valentini P, Buonsenso D.

Cardiopulmonary Exercise Testing in Children With Long COVID: A Case-controlled

Study. The Pediatric Infectious Disease Journal. 2024 May 7:10-97.

6. Cocciolillo F, Chieffo DP, Giordano A, Arcangeli V, Lazzareschi I, Morello R, Zampino G,

Valentini P, Buonsenso D. Case report: Post-COVID new-onset neurocognitive decline with bilateral mesial-temporal hypometabolism in two previously healthy sisters. Fr

7. Cocciolillo F, Di Giuda D, Morello R, De Rose C, Valentini P, Buonsenso D. Orbito-frontal cortex

hypometabolism in children with post-COVID condition (long COVID): a preliminary experience. The Pediatric Infectious Disease Journal. 2022 Aug 1;41(8):663-5.

Professor Danny Altmann is a professor of Immunology at Imperial College London in the UK. In this interview, Professor Altmann defines Long COVID.

Research Articles:

1. Altmann DM, Whettlock EM, Liu S, Arachchillage DJ, Boyton RJ. The

immunology of long COVID. Nature Reviews Immunology. 2023

Oct;23(10):618-34.

2. Elneima O, McAuley HJ, Leavy OC, Chalmers JD, Horsley A, Ho LP, Marks M,

Poinasamy K, Raman B, Shikotra A, Singapuri A. Cohort profile:

post-hospitalisation COVID-19 (PHOSP-COVID) study. International Journal

of Epidemiology. 2024 Feb 1;53(1):dyad165.

3. Scheppke KA, Pepe PE, Jui J, Crowe RP, Scheppke EK, Klimas NG, Marty AM.

Remission of severe forms of long COVID following monoclonal antibody

(MCA) infusions: A report of signal index cases and call for targeted

research. The American Journal of Emergency Medicine. 2024 Jan

1;75:122-7.