Every few days, your gut rebuilds itself completely - cell by cell, guided by signals we still don’t fully understand. For years, scientists have known that diet can influence this process, but the exact messenger between what we eat and how the gut heals has remained a mystery.

In this episode, we look at new research from MIT that uncovers a surprising link between diet, the immune system, and regeneration in the intestine. It’s a story about how a single nutrient can activate immune cells to release molecules that tell the gut when it’s time to repair.

It challenges the way we think about food, not just as fuel, but as information. Because the gut isn’t just digesting what we eat… it’s listening.

00:00 Introduction to Gut Regeneration

00:56 The Role of Amino Acids in Gut Health

02:07 ???: A Key Player in Gut Regeneration

02:35 MIT's Groundbreaking Research

03:49 The Immune System's Role in Gut Regeneration

05:51 Dietary Sources and Implications

07:07 Conclusion: The Gut's Adaptive Nature

PMID: 41034585

Creatine’s story has been far too small for its biology. Most people still see it as a supplement for strength or cognitive performance, but its most important work happens inside the mitochondria.

In this episode, we explore a side of creatine few people talk about: how it may function as mitochondrial medicine. We’ll break down 3 distinct ways creatine acts in and supports the mitochondria; roles that could reshape how we think about energy, resilience, and cellular health. And beyond that, how creatine may be one of the few molecules that can both diagnose and treat mitochondrial dysfunction.

00:00 Understanding Mitochondrial Dysfunction

00:43 Introduction to Creatine's Role

01:16 Mitochondrial Dysfunction Explained

01:56 Creatine as a Theranostic Agent

02:57 Mechanisms of Creatine in Mitochondria

04:09 Therapeutic Roles of Creatine

05:22 Redox Control and Antioxidant Properties

06:27 Conclusion: The Unique Power of Creatine

PMID: 40948982

In this episode of The Daily Value, we look at new research suggesting that polyphenols might be doing something we never expected — not just acting as antioxidants, but organizing themselves into microscopic structures that can stabilize the very proteins that keep our cells alive. It’s a discovery that could reshape how we think about plant compounds and resilience at the molecular level. We explore how this structural behavior gives new meaning to the idea that diversity matters in our diet — and why the age-old advice to “eat the color spectrum” may be more scientifically accurate than anyone realized.

00:00 – The Flavonoid Paradox: Quantity vs. Diversity
01:12 – What Are Polyphenols Really Doing in the Body?
02:16 – Diversity as a Predictor of Longevity and Disease Risk
03:17 – Beyond Antioxidants: A New Molecular Hypothesis
03:58 – Self-Assembling Flavonoids and Protein Stabilization
05:45 – Mechanistic Insight: How Molecular Networks Support Cellular Resilience
09:45 –The Science Behind “Eat the Color Spectrum”