Our topic in this episode is progress with ending aging. Our guest is the person who literally wrote the book on that subject, namely the book, “Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime”. He is Aubrey de Grey, who describes himself in his Twitter biography as “spearheading the global crusade to defeat aging”.

In pursuit of that objective, Aubrey co-founded the Methuselah Foundation in 2003, the SENS Research Foundation in 2009, and the LEV Foundation, that is the Longevity Escape Velocity Foundation, in 2022, where he serves as President and Chief Science Officer.

Full disclosure: David also has a role on the executive management team of LEV Foundation, but for this recording he was wearing his hat as co-host of the London Futurists Podcast.

The conversation opens with this question: "When people are asked about ending aging, they often say the idea sounds nice, but they see no evidence for any actual progress toward ending aging in humans. They say that they’ve heard talk about that subject for years, or even decades, but wonder when all that talk is going to result in people actually living significantly longer. How do you respond?"

Selected follow-ups:

• Aubrey de Grey on X (Twitter)
• The book Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime
• The Longevity Escape Velocity (LEV) Foundation
• The SENS paradigm for ending aging , contrasted with the "Hallmarks of Aging" - a 2023 article in Rejuvenation Research
• Progress reports from the current RMR project
• The plan for RMR 2
• The RAID (Rodent Aging Interventions Database) analysis that guided the design of RMR 1 and 2
• Longevity Summit Dublin (LSD): 13-16 June 2024
• Unblocking the Brain’s Drains to Fight Alzheimer’s - Doug Ethell of Leucadia Therapeutics at LSD 2023 (explains the possible role of the cribriform plate)
• Targeting Telomeres to Clear Cancer – Vlad Vitoc of MAIA Biotechnology at LSD 2023
• How to Run a Lifespan Study of 1,000 Mice - Danique Wortel of Ichor Life Sciences at LSD 2023
• XPrize Healthspan
• The Dublin Longevity Declaration ("DLD")

Music: Spike Protein, by Koi Discovery, available under CC0 1.0 Public Domain Declaration