• ROS1-Alterations and Molecular Testing in Advanced NSCLC

  • Aug 28 2024
  • Length: 16 mins
  • Podcast

ROS1-Alterations and Molecular Testing in Advanced NSCLC

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  • Summary

  • In this episode, listen to Alice T. Shaw, MD, PhD, and Jessica J. Lin, MD, share their thoughts on the current understanding of ROS1 rearrangements in non-small-cell lung cancer tumor biology and its implications for molecular testing and treatment selection including:

    • ROS1-gene fusions in advanced lung cancer
    • ROS1 testing recommendations with DNA NGS, RNA NGS, FISH break apart assay, and IHC
    • Comparative specificity of ROS1 and ALK targeting tyrosine kinase inhibitors
    • Advantages of RNA- vs DNA-based next-generation sequencing

    Program faculty:

    Jessica J. Lin, MD
    Attending Physician
    Massachusetts General Hospital
    Associate Professor of Medicine
    Harvard Medical School
    Boston, Massachusetts

    Alice T. Shaw, MD, PhD
    Chief, Strategic Partnerships
    Attending Physician, Thoracic Oncology
    Dana-Farber Cancer Institute
    Harvard Medical School
    Boston, Massachusetts

    Resources:

    To download the slides associated with this podcast discussion, please visit the program page
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