Featuring perspectives from Dr Matthew D Galsky, Dr Shilpa Gupta, Dr Terence Friedlander and Prof Andrea Necchi, moderated by Dr Friedlander, including the following topics:

• Introduction (0:00)
• Optimal Use of Anti-PD-1/PD-L1 Antibodies in Non-Muscle-Invasive Bladder Cancer — Dr Friedlander (2:27)
• Evolving Management of Muscle-Invasive Bladder Cancer — Dr Gupta (33:30)
• Current and Future Role of Novel Intravesical Therapies in Nonmetastatic Urothelial Bladder Cancer (UBC) — Prof Necchi (1:01:56)
• Emerging Utility of Circulating Tumor DNA Evaluation in Nonmetastatic UBC — Dr Galsky (1:32:47)

CME information and select publications

Featuring perspectives from Dr Jaffer A Ajani, Dr Samuel J Klempner, Dr Rutika Mehta and Dr John Strickler, moderated by Dr Klempner, including the following topics:

• Younger patient with metastatic HER2-positive, PD-L1-positive gastric cancer (0:00)
• Older patient with metastatic HER2-positive gastroesophageal (GE) cancer (8:13)
• Clinical applications for zanidatamab in GE cancer (13:58)

CME information and select publications

Featuring perspectives from Dr Paul G Richardson, including the following topics:

• Mechanism of action and pharmacology of cereblon E3 ligase modulators (0:00)
• Available efficacy data (4:54)
• Extramedullary disease (10:51)
• Side effects and toxicity (16:58)

CME information and select publications

Featuring an interview with Dr Hanny Al-Samkari, including the following topics:

• Case: A woman in her early 70s incidentally diagnosed with immune thrombocytopenia (ITP) experiences a suboptimal response to prednisone and IVIG — Bhavana (Tina) Bhatnagar, DO (0:00)
• Case: A man in his early 50s with a long history of ITP undergoes splenectomy — Neil Morganstein, MD (5:06)
• Case: A woman in her mid 50s with symptomatic iron-deficiency anemia who was found to have ITP has received corticosteroids, rituximab and IVIG — Jennifer Yannucci, MD (12:25)
• Case: A woman in her early 30s who previously received ABVD (doxorubicin/bleomycin/vinblastine/dacarbazine) and autologous stem cell transplant for Hodgkin lymphoma is diagnosed with ITP 5 years later that is refractory to high-dose prednisone, IVIG and rituximab, then romiplostim — Priya Rudolph, MD, PhD (18:19)

CME information and select publications

Featuring perspectives from Dr Haley Ellis, Prof Eric Van Cutsem and Dr Zev Wainberg, moderated by Dr Lionel A Kankeu Fonkoua, including the following topics:

• Novel immune checkpoint inhibitors (0:00)
• Gastroesophageal junction cancer (7:36)
• Gastric cancer (14:52)

CME information and select publications

Featuring an interview with Dr Lajos Pusztai, including the following topics:

• Circulating tumor DNA monitoring for patients with ER-positive, HER2-negative high-risk breast cancer during adjuvant endocrine therapy (0:00)
• Clinical performance of a whole-genome assay for predicting disease recurrence (5:52)
• Using circulating tumor DNA status to personalize CDK4/6 inhibitor therapy (12:46)
• Neoadjuvant and adjuvant therapy stratified by circulating tumor DNA status (21:11)
• Utility of circulating tumor DNA status in the management of metastatic breast cancer (24:55)

CME information and select publications

Featuring an interview with Dr Ravin Ratan, including the following topics:

• Efficacy and safety of long-term continuous nirogacestat treatment in adults with desmoid tumors: Results from the Phase III DeFi trial (0:00)
• Onset and resolution of ovarian toxicity with nirogacestat treatment for desmoid tumors: Updated safety analyses from the DeFi trial (4:37)
• Subgroup analysis of the Phase II part of the RINGSIDE Phase II/III trial of varegacestat for desmoid tumors (7:39)
• Surgical management of desmoid tumors; cryotherapy in the treatment of extra-abdominal desmoid tumors (10:30)

CME information and select publications

Featuring perspectives from Dr Haley Ellis, Prof Eric Van Cutsem and Dr Zev Wainberg, moderated by Dr Lionel A Kankeu Fonkoua, including the following topics:

• Biliary tract cancer progressing on first-line therapy (0:00)
• Gallbladder cancer (5:01)
• Biliary tract cancer with multiple biomarker targets (8:52)

CME information and select publications