• You’ve probably often heard that “Clinical trials show..” or “ evidence support that..”
• Unfortunately, a research paper being published in a peer-reviewed medical journal is NOT a guarantee that it is clinically relevant  - even if it is a high ranking journal
• As it is often the case the devil is in the details, so it is necessary to both read and evaluate the paper’s details and to put it into the context where you need the information
• In this episode, we will talk about the details you need to look for

GET THE ABSTRACT SCREENING TOOL

It can be a challenge to screen papers for clinical relevance. As we go beyond the abstract in this podcast, we have created a screening tool you can use when reading an abstract from a clinical research paper.

Using that tool enables you to quickly screen an abstract from a medical journal for clinical relevance selecting only those you want to read. At the same time, you will know why you skipped the rest. Get it at our website https://www.precision-evidence.com 

LINKS:

Evaluating clinical relevance in 2 x 2 matrix https://www.precision-evidence.com/matrix

96% of published studies mention a p-value at 0.05 or lower: “What Have We (Not) Learned from Millions of Scientific Papers with P Values?” https://www.tandfonline.com/doi/full/10.1080/00031305.2018.1447512 

Overview of clinical trials registers like clinicaltrials.gov: https://sites.google.com/a/york.ac.uk/yhectrialsregisters/home/clinicaltrials 

PRECISION EVIDENCE ON TOP LIST

Precision Evidence has been selected by Feedspot to the list of  

Top 35 Clinical Trials Podcasts You Must Follow in 2021

https://blog.feedspot.com/clinical_trials_podcasts/ 

NOTES:

• The conclusion in a clinical research paper is based on an analysis of data collected from a specific group of people: the study population
• We have developed helpful tools to guide and help you with the process of screening afnf evaluate a paper from a clinical trial
• • The Abstract Screening Tool
  • The Precision Evidence Matrix for Clinical Relevance
  • Links to both above
• The clinical usefulness depends on inclusion and exclusion criteria as well as the study design and method
• The relevance of inclusion and exclusion 
•  Can results be extrapolated to persons not included in a specific clinical trial?
• What are the relevant outcomes?
• Clinicaltrials.gov Why it is good and what is missing
• Clinical relevance
• P-values vs. clinical relevance
• Precision of evidence
• Using surrogate measurements as a stand-in for what we really want to know
• How do you interpret the results from clinical trials?
• Can researchers adjust the design and study population after data collection to improve outcomes?
•  How to save time reading and evaluating clinical research papers

  Contact us at email: podcast@precision-evidence.com,

Twitter @PrecisionEBM,

website: www.precision-evidence.com

Hosts:

Dr. Kim Kristiansen, M.D: @KKristiansenMD

JG Staal: @HealthyEvidence

 Music thanks to mixkit.co