Today on TWiM, a charcuterie invasion, and how that acid in your stomach may protect from the invading hordes of microbes.

Hosts: Michael Schmidt, Petra Levin and Michele Swanson.

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• 2024 Salmonella outbreak linked to charcuterie meats
• Multitier regulation of the E. coli extreme acid stress response by CsrA
• Commentary: Peeling the onion: additional layers of regulation in the acid stress response
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TWiM reviews a case of E. faecium bacteremia treated with combination bacteriophage and antibiotic therapy, and how dopamine receptor D2 confers colonization resistance via microbial metabolites.

Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.

Guest: Mark O. Martin

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• Matters Microbial
• Distinct Fusobacterium dominates colorectal cancer (Nature)
• Bacterial subspecies that might drive colon cancer (Nature)
• A bacterial strain linked to colon cancer (Nature)
• Spatial perspective on bacteria in tumors (Nature)
• Colorectal cancer in the young (Yale Med)
• Surface colonization by Flavobacterium johnsoniae promotes its survival (mBio)
• THOR, a model microbiome (mBio)
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TWiM reviews a case of E. faecium bacteremia treated with combination bacteriophage and antibiotic therapy, and how dopamine receptor D2 confers colonization resistance via microbial metabolites.

Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.

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• Vincent’s interviews at SXSW
• Bacteriophage and antibiotic therapy for E. faecium bacteremia (mBio)
• Dopamine receptor D2 confers colonization resistance (Nature)
• CDC’s Reports of Selected E. coli Outbreak Investigations
• Brett Finlay’s narrated EPEC animation
• Colonization resistance by gut microbial metabolome (ACS Chem Biol)
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TWiM discusses the identification of natural products from reconstructed ancient bacterial genomes, and how plant mRNAs move into a fungal pathogen via extracellular vesicles to reduce infection.

Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin.

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• Natural products from ancient bacterial genomes (Science)
• Plant mRNAs move into fungal pathogens (Cell Host Microb)
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TWiM reviews the ongoing cholera outbreak in Africa, and research showing that gut complement induced by the microbiota blocks pathogens and spares commensal bacteria.

Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.

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• Cholera in Southern Africa (Africa CDC)
• Deadly cholera outbreak in Africa (NY Times)
• Pediatric cholera in sub-Saharan Africa (Curr Op Ped)
• Gut complement spares commensals (Cell)
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TWiM reveals a new population in the blue cheese-making fungus Penicillium roqueforti and identification of a quorum-sensing autoinducer and siderophore in uropathogenic Escherichia coli.

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• New blue cheese-making fungus (Evol Appl)
• Threat to Camenbert cheese (Guardian)
• French Cheese Under Threat (CNRS News)
• Fungadapt project (YouTube)
• Microbes Make the Cheese (ASM)
• Yersiniabactin in uropathogenic Escherichia coli (mBio)
• Public goods and cheating in microbes (Curr Biol)
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TWiM reveals a database of genome sequences of thousands of Mycobaterium tuberculosis, allowing association with resistance phenotypes to 13 antibiotics, and microbe-derived uremic solutes that enhance thrombosis potential in the host.

Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson.

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• M. tuberculosis genomes and antimicrobial resistance (PLoS Biol)
• The CRyPTIC consortium
• BashTheBug
• Zooniverse
• Microbial solutes enhance thrombosis (mBio)
• Can our microbiome break our heart? (mBio)
• Pathogenesis of cardiovascular disease (EJIFCC)
• How Kidneys Work Video (Mayo Clinic)
• What is a metaorganism? (Zoology)
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TWiM describes the mechanism for the S. aureus itch and scratch induced skin damage, and discovery of a novel class of antibiotics that targets the lipopolysaccharide transporter.

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Links:

• S. aureus drives itch and scratch behavior (Cell)

• Staph scratches its itch (Cell)

• A new class of antibiotics (Nature)

• A new type of antibiotic (Nature)

• Novel antibiotic targets LPS transporter (Nature)

• New antibiotic traps LPS (Nature)

• Macrocyclic peptide drugs (Science)

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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