Sam Harris speaks with Dr. Jennifer Mitchell and Dr. Sarah Abedi about recent developments in research on psychedelics. They discuss the history of this research and the war on drugs, recent setbacks in the FDA approval process, MDMA as a treatment for post-traumatic stress disorder (PTSD), the challenges of conducting this research, allegations of therapist misconduct, new therapeutic models for mental health treatment, psychoneuroimmunology, "non-psychedelic" psychedelics, good and bad trips, the FDA's coming decision on MDMA-assisted therapy, "right-to-try" policies for pharmaceuticals, the role of psychedelic therapists, the problem of having all this therapeutic work being done underground, and other topics.

Petition to approve MDMA-assisted therapy for PTSD: https://www.approvemdmatherapy.com/

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Learning how to train your mind is the single greatest investment you can make in life. That’s why Sam Harris created the Waking Up app. From rational mindfulness practice to lessons on some of life’s most important topics, join Sam as he demystifies the practice of meditation and explores the theory behind it.

Sam Harris and Anne Applebaum discuss the nature of modern autocracies and how democracies fail. They discuss the power of ideas, why autocracies seek to undermine democracies, cooperation among dictators, how Western financial experts and investors have enabled autocracies, how Putin came to power, the failure of engagement and investment to create political change, what’s at stake in the war in Ukraine, Trump’s charisma, the current symptoms of American democratic decline, the ideologues around Trump, the hollowing out of institutions, how things might unravel in America, anti-liberal tendencies in American politics, the role of social media, the different pathologies on the Left and Right, analogies to Vichy France, the weakness of the Democrats, the political effects of the assassination attempt on former President Trump, and other topics.

If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.

If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.