Do you ever wonder why we think that LDL plays such a big role in atherosclerosis, and why we try to lower it? Well in this episode we dive deep into the landmark studies that paved the way for the LDL hypothesis.

00:00 - Start

00:23 - Introduction

01:02 - Importance

02:02 - LDL review

04:09 - Atherosclerosis Review

06:14 - History of LDL/lipid Research

09:14 - 3 types of supporting data

12:14 - Framingham Studies

13:31 - 4S Trial

14:34 - West of Scotland Study

15:24 - CARE Trial

16:37 - Heart Protection Study

17:03 - PROSPER Study

17:53 - PROVE IT - TIMI 22 Trial

19:03 - IDEAL Trial

20:12 - REVERSAL Trial

21:15 - ASTEROID Trial

22:18 - IMPROVE-IT

23:52 - DESCARTES Study

25:17 - OSLER 1/2 Trials

26:12 - ODYSSEY LONG-TERM Study

27:03 - GLAGOV Study

27:43 - LDL lowering and risk reduction meta analysis

28:41 - FOURIER Trial

29:12 - ODYSSEY OUTCOMES

29:52 - Further lowering LDL meta analysis

31:11 - CLEAR HARMONY Trial

32:23 - What is optimal LDL study

33:58 - Mendelian Randomization

36:22 - Putting it all together

38:43 - Summary

See www.jrennickemd.com for list of references

*Disclaimer* This video is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.