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A Fatal Inheritance
- How a Family Misfortune Revealed a Deadly Medical Mystery
- Narrado por: Roger Wayne
- Duración: 9 h y 25 m
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Resumen del Editor
Weaving his own moving family story with a sweeping history of cancer research, Lawrence Ingrassia delivers an intimate, gripping tale that sits at the intersection of memoir and medical thriller
Ingrassia lost his mother, two sisters, brother, and nephew to cancer—different cancers developing at different points throughout their lives. And while highly unusual, his family is not the only one to wonder whether their heartbreak is the result of unbelievable bad luck, or if there might be another explanation.
Through meticulous research and riveting storytelling, Ingrassia takes us from the 1960s—when Dr. Frederick Pei Li and Dr. Joseph Fraumeni Jr. first met, not yet knowing that they would help make a groundbreaking discovery that would affect cancer patients for decades to come—to present day, as Ingrassia and countless others continue to unpack and build upon Li and Fraumeni’s initial discoveries, and to understand what this means for their families.
In the face of seemingly unbearable loss, Ingrassia holds onto hope. He urges us to “fight like Charlie,” his nephew who battled cancer his entire life starting with a rare tumor in his cheek at the age of two—and to look toward the future, as gene sequencing, screening protocols, CRISPR gene editing, and other developing technologies may continue to extend lifespans and perhaps, one day, even offer cures.
A Macmillan Audio production from Henry Holt & Company.
Reseñas de la Crítica
“A Fatal Inheritance by Lawrence Ingrassia is a compelling personal chronicle of tragedy and triumph. It captures both the ineffable pain of families riddled with cancers and the remarkable research over the past half century by scientists determined to help them.”—Siddhartha Mukherjee, author of The Emperor of All Maladies: A Biography of Cancer
"When two young doctors came across a family riddled with cancer for generations, they wondered why and began a decades long search for the answer. In A Fatal Inheritance, a riveting narrative of their quest, Lawrence Ingrassia intertwines a deeply personal and tearful story of unbearable family loss with an inspiring story of scientific discovery that revolutionized the understanding and treatment of cancer."—Walter Isaacson, author of Elon Musk, The Code Breaker and Steve Jobs
"When Lawrence Ingrassia lost his mother, sisters, brother and nephew to cancer, was it appallingly bad luck, or was there a common cause? This is the story of a family tragedy, a medical mystery, and the painstaking work of insightful scientists. By turns heartbreaking and hopeful, A Fatal Inheritance is a story of mortal loss and human resilience."—Geraldine Brooks, author of Horse and March
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Why did humans abandon hunting and gathering for sedentary communities dependent on livestock and cereal grains and governed by precursors of today's states? Most people believe that plant and animal domestication allowed humans, finally, to settle down and form agricultural villages, towns, and states, which made possible civilization, law, public order, and a presumably secure way of living. But archaeological and historical evidence challenges this narrative.
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World without Women
- De Paul Richards en 04-28-18
De: James C. Scott
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Inspired
- How to Create Tech Products Customers Love, Second Edition
- De: Marty Cagan
- Narrado por: Marty Cagan
- Duración: 7 h y 45 m
- Versión completa
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How do today's most successful tech companies - Amazon, Google, Facebook, Netflix, Tesla - design, develop, and deploy the products that have earned the love of literally billions of people around the world? Perhaps surprisingly, they do it very differently from the vast majority of tech companies. In Inspired, technology product management thought leader Marty Cagan provides listeners with a master class in how to structure and staff a vibrant and successful product organization and how to discover and deliver technology products that your customers will love.
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Great book, terrible audio wanted to ask a refund
- De Srikanth Ramanujam en 11-15-18
De: Marty Cagan
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Chemistry and Our Universe
- How It All Works
- De: Ron B. Davis, The Great Courses
- Narrado por: Ron B. Davis
- Duración: 30 h y 6 m
- Grabación Original
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Chemistry and Our Universe: How It All Works is your in-depth introduction to this vital field, taught through 60 engaging half-hour lectures that are suitable for any background or none at all. Covering a year’s worth of introductory general chemistry at the college level, plus intriguing topics that are rarely discussed in the classroom, this amazingly comprehensive course requires nothing more advanced than high-school math. Your guide is Professor Ron B. Davis, Jr., a research chemist and award-winning teacher at Georgetown University.
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Great Professor, Hard to Follow.
- De Jen en 05-14-19
De: Ron B. Davis, y otros
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Ranger Confidential
- Living, Working, and Dying in the National Parks
- De: Andrea Lankford
- Narrado por: Julia Motyka
- Duración: 9 h y 28 m
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The real stories behind the scenery of America’s national parks. For 12 years, Andrea Lankford lived in the biggest, most impressive national parks in the world, working a job she loved. She chaperoned baby sea turtles on their journey to sea. She pursued bad guys on her galloping patrol horse. She jumped into rescue helicopters bound for the heart of the Grand Canyon. She won arguments with bears. She slept with a few too many rattlesnakes. Hell yeah, it was the best job in the world! Fortunately, Andrea survived it.
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Depressing from Cover to Cover
- De Drew (@drewsant) en 04-13-15
De: Andrea Lankford
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The Grid
- The Fraying Wires Between Americans and Our Energy Future
- De: Gretchen Bakke
- Narrado por: Emily Caudwell
- Duración: 11 h y 8 m
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The grid is an accident of history and of culture, in no way intrinsic to how we produce, deliver and consume electrical power. Yet this is the system the United States ended up with, a jerry-built structure now so rickety and near collapse that a strong wind or a hot day can bring it to a grinding halt. The grid is now under threat from a new source: renewable and variable energy, which puts stress on its logics as much as its components.
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A disappointment
- De Ronald en 09-24-16
De: Gretchen Bakke
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Storytelling with Data
- A Data Visualization Guide for Business Professionals
- De: Cole Nussbaumer Knaflic
- Narrado por: Cole Nussbaumer Knaflic
- Duración: 5 h y 43 m
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Storytelling with Data teaches you the fundamentals of data visualization and how to communicate effectively with data. You'll discover the power of storytelling and the way to make data a pivotal point in your story. The lessons in this illuminative text are grounded in theory but made accessible through numerous real-world examples - ready for immediate application to your next graph or presentation.
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Very insightful and actionable
- De Amazon Customer en 04-27-18
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Naked Statistics
- Stripping the Dread from the Data
- De: Charles Wheelan
- Narrado por: Jonathan Davis
- Duración: 10 h y 48 m
- Versión completa
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From batting averages and political polls to game shows and medical research, the real-world application of statistics continues to grow by leaps and bounds. How can we catch schools that cheat on standardized tests? How does Netflix know which movies you'll like? What is causing the rising incidence of autism? As best-selling author Charles Wheelan shows us in Naked Statistics, the right data and a few well-chosen statistical tools can help us answer these questions and more.
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Starts well then becomes non-Audible
- De Michael en 09-07-13
De: Charles Wheelan
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In her debut memoir, Nowhere for Very Long, Brianna Madia reflected on her life as a nomad, free to roam some of the most beautiful land in America. Now, in Never Leave the Dogs Behind, the van life adherent faces the unfathomable darkness that comes from a life blown apart, her only solace the support of her dogs.
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In 2011, three successful and highly educated women fell head over heels for the brilliant and charming Ethan Schuman. Unbeknownst to the others, each exchanged countless messages with Ethan, staying up late into the evenings to deepen their connections with this fascinating man. His detailed excuses about broken webcams and complicated international calling plans seemed believable, as did last minute trip cancellations. After all, why would he lie? Ethan wasn't after money—he never convinced his marks to shell out thousands of dollars for some imagined crisis.
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Genevieve (Gwen) Kingston was just eleven years old when her mother passed away, leaving behind a chest filled with gifts and letters to celebrate the milestones of Gwen’s life and each of her birthdays until age thirty.
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At nine, Sean Connery saved him from drowning. At thirteen, desperate to hook up with Janis Joplin, he attended his aunt Joan Didion and uncle John Gregory Dunne’s legendary LA launch party for Tom Wolfe’s The Electric Kool-Aid Acid Test. At sixteen, he got kicked out of boarding school, ending his institutional education for good.
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Not funny but still worthy
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To the rest of the world, Cass Elliot was a rock star; A charismatic, wisecracking singer from the Rock & Roll Hall of Fame inducted band, The Mamas & The Papas; A legend of Laurel Canyon, decked out in her custom-made Muumuus, glittering designer jewelry, blessed with a powerful, instantly identifiable singing voice which helped define the sound of the 1960s counterculture movement. But to Owen Elliot-Kugell, she was just Mom. In her long-awaited memoir, Owen Elliot-Kugell shares the groundbreaking story of her mom as only a daughter can tell it.
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Patric Gagne realized she made others uncomfortable before she started kindergarten. Something about her caused people to react in a way she didn’t understand. She suspected it was because she didn’t feel things the way other kids did. Emotions like fear, guilt, and empathy eluded her. For the most part, she felt nothing. And she didn’t like the way that “nothing” felt.
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In her debut memoir, Nowhere for Very Long, Brianna Madia reflected on her life as a nomad, free to roam some of the most beautiful land in America. Now, in Never Leave the Dogs Behind, the van life adherent faces the unfathomable darkness that comes from a life blown apart, her only solace the support of her dogs.
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Meh
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In 2011, three successful and highly educated women fell head over heels for the brilliant and charming Ethan Schuman. Unbeknownst to the others, each exchanged countless messages with Ethan, staying up late into the evenings to deepen their connections with this fascinating man. His detailed excuses about broken webcams and complicated international calling plans seemed believable, as did last minute trip cancellations. After all, why would he lie? Ethan wasn't after money—he never convinced his marks to shell out thousands of dollars for some imagined crisis.
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Waiting in the emergency room at Temple University Hospital in North Philadelphia where his eighteen-year-old nephew, Nasir, lay unconscious after being shot nine times, MK Asante began pouring his heart and soul into a series of letters to a beautiful, dying Black boy so full of life. As Nasir fought for survival, MK realized there was so much—too much—that he had kept from his nephew, starting with the truth about his father, MK’s brother, Uzi, whom Nasir had never met. MK could no longer remain silent because in many ways, his nephew was repeating the mistakes of the past.
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They say that revenge is a dish best served cold - but how cold does it have to be? ?And should it be chopped, sliced or diced? What dish is best suited to a man who at one point had an ex-wife, a wife, a pregnant girlfriend and a new girlfriend - all at the same time? I was an independent, clever, blonde and slightly wild 31-year old Swedish girl when I in 1998 met the man of my dreams.
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In When Women Ran Fifth Avenue, journalist Julie Satow draws back the curtain on three visionaries who took great risks, forging new paths for the women who followed in their footsteps. This stylish account, rich with personal drama and trade secrets, captures the department store in all its glitz, decadence, and fun, and showcases the women who made that beautifully curated world go round.
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Read like a text book for fashion students.
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Between Two Trailers
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Dana Trent is only a preschooler the first time she uses a razor blade to cut up weed and fill dime bags for her schizophrenic father, King. While King struggles with his unmedicated psychosis, Dana’s mother, the Lady, a cold and self-absorbed woman whose personality disorders rule the home, guards large bricks of drugs from the safety of their squalid trailer. But when the Lady impulsively plucks Dana from the Midwest and moves the two of them south, their fresh start results in homelessness and bankruptcy.
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excellent book
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Committed
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When Suzanne Scanlon was a student at Barnard in the '90s, grieving the loss of her mother—feeling untethered and swimming through inarticulable pain—she made a suicide attempt that landed her in the New York State Psychiatric Institute. After nearly three years and countless experimental treatments, Suzanne left the ward on shaky legs. In the decades it took her to recover from the experience, Suzanne came to understand her suffering as part of something larger.
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Confessions of a Sociopath
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As M. E. Thomas says of her fellow sociopaths, we are your neighbors, co-workers, and quite possibly the people closest to you: lovers, family, friends. Our risk-seeking behavior and general fearlessness are thrilling, our glibness and charm alluring. Our often quick wit and outside-the-box thinking make us appear intelligent - even brilliant. We climb the corporate ladder faster than the rest, and appear to have limitless self-confidence.... Who are we? We are highly successful, non-criminal sociopaths and we comprise 4% of the American population (that's 1 in 25 people!).
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Not a sociopath!
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The Assassination of Barbara O'Neill
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How could a 66-year-old grandmother, who gave her life to helping people with their health, become the subject of a malicious smear campaign which resulted in her being classified as a serious threat to public health in Australia? This book exposes the hypocrisy of the organization Friends of Science in Medicine who act as 'friends of science', but are in reality pharmaceutical apologists and the 'Enemies of Truth in Medical Science'. Barbara became collateral damage in the war on any dissent from mainstream medical dogma.
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An award-winning and best-selling memoir, An Impossible Life, tells the powerful true account of one woman's descent into depressive and manic episodes and how she found lifesaving therapy and medication to overcome and triumph.
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Discover the Hidden Strengths Within Introversion and Extroversion. Learn how to embrace your unique personality type and use it to your advantage. Understand the power of introversion and extroversion and how it shapes our relationships and professional lives.
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Ever wonder about how the federal justice system really works? Now you can experience it, really feel it, up close and personal. Welcome to Matt Connolly's world. It starts with the Libor investigation into Deutsche Bank, followed by Matts interview with the FBI. Then comes his indictment and a trial in the country's most prestigious federal court, the Southern District of New York in Manhattan. This book pulls no punches. Every rabbit hole is plumbed; every lie, backstab, and shady deal is exposed. You may be surprised at which side is pulling the strings.
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Because I Didn't Tell, Revised Edition
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In Because I Didn't Tell, author Suzanne Harmony offers a self-help autobiography detailing an account of the horrific events of her young adult life. These events fiercely unraveled her one-safe world into a dungeon of despair propelled by life-or-death threats and brain-washed promises of "not to tell". Her journey through hell, led by the devil himself, clearly demonstrates the destructive trail of deceit, including lying to herself, in her desperate attempt to save lives: her own, her unborn child's, and her family members'.
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The One Armed Whiskey Man of Jackass Canyon
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The One-Armed Whiskey Man of Jackass Canyon daylights a newly excavated vein in the Golden State of mind. It follows the unbelievably true life and times of accidental California pioneer Thomas D Carneal III. His prominent Northern Kentucky clan carved an ironic notch into the whiskey rebellion of 1790's and beyond. Out of the blue, tragedy struck, and the family legacy ricocheted off to the wilds of 1850’s Northern California, landing on a historic rancho, shortly after California statehood.
Lo que los oyentes dicen sobre A Fatal Inheritance
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Historia
- Avid reader
- 05-17-24
Powerful story told incredibly well
Cancer decimated the author's family, taking lives way too soon, way too often, as he recounts in this book. But this story is much bigger than that. It's an incredibly powerful tale, not just of his family, but of other families, of posing questions and seeking answers. The lyrical prose of his retelling reads like a novel, while his decades as a journalist with the Wall Street Journal, the New York Times, and the Los Angeles Times come through in his detailed chronicling of the journey to unwrap the medical mystery of why his branch of the family (and so many other families) have been plagued by cancer. He skillfully distills medical research into everyday language so that readers can understand the science, while he pieces in families' stories so that they can empathize with the real-life toll cancer takes on so many.
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- mmk
- 06-05-24
Fascinating history, heartbreaking story
I am affected by an inherited genetic mutation with increased cancer risk, and an advocate for expanded germline genetic testing for more people, I feel like I am pretty knowledgeable about the topic but I did not know the backstory and history of the way researchers worked to discover and demonstrate the cancer-genetic link. It was very interesting and told in a way that was technical yet understandable - and interesting! The author wove this background history into the devastating losses in his own family that came, one after another, just a bit too early in time for the discoveries of the genetic link to be beneficial for them. I listened to this audiobook twice to absorb it all. I rarely leave reviews, but this one touched me. I hope it is read widely and that even one family will take a closer look at their family experience with cancer and inquire about germline testing - it could save the lives of the current and next generations.
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- Lisa Ingrassia
- 06-07-24
Stunning story and great reporting
Beautifully reported book, wonderfully read by the narrator. The book intertwines the authors story of losing his entire family to cancer with the story of the epidemiologists who discovered a cancer gene, and the families they studied on their path. This book will be interesting to anyone who has lost a family member to cancer and grappled with fear and grief around that loss.
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- Katherine
- 05-20-24
An important book
This book blends the heart wrenching story of the Ingrassia family and how cancer shadowed three generations with chronicling the discovery of a genetic link. Superb story telling that keeps the reader engaged even as we can anticipate the devastating outcome. The science is conveyed clearly, so that non-scientists can grasp the progress to discovering the key mutation. Engrossing, illuminating and personal.
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- Linda Thompson
- 06-02-24
An Elucidating Memoir
Mr. Ingrassia has managed to write a reader friendly treatise on cancer research that reads like a novel. With a journalist’s talent for getting to the heart of a story in a clear and concise manner, he educates the reader on the process of medical research all the while interspersing the technical issues with the very touching human stories of families, including his own, plagued by recurring cancers. This memoir is truly a masterpiece of research by the author as well as a love letter to his family.
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- Georgia Reviewer
- 06-16-24
Way more focused on the medicine than the memoir.
While the topic is interesting and important, I found the bouncing back and forth between the medical research and the personal stories of many people and families to be distracting and tiring. The narration is fantastic and the medical points are explained in basic terms with good analogies. I did not appreciate the format.
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