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Neurotech Pub

By: Paradromics Inc
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  • Summary

  • Paradromics Founder and CEO Matt Angle hosts an informal salon with some of the most influential figures in neurotechnology.
    Copyright 2020 Paradromics Inc
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Episodes
  • Your Future Self Will Thank You | Connectomics Part II

    Your Future Self Will Thank You | Connectomics Part II
    Mar 22 2023
    We’re back with Part II of our two-part series on Connectomics! In part one we speculated on the legal and ethical implications of emerging technologies in the connectomics field. In part two, we don our lab coats and take a deep dive into the latest research tools, from fixation protocols for the preservation of neural tissue, to multimodal imaging techniques, to the machine intelligence designed to interpret massive data sets and reconstruct the vast neural circuits that make up the connectome. Our guests are:  Kenneth Hayworth, PhD, President and Co-Founder of the Brain Preservation Foundation, Senior Scientist at the Howard Hughes Medical Institute’s Janelia Farm Research Campus (JFRC) Robert McIntyre, CEO at Nectome Jeremy Maitin-Shepard, PhD, Software Engineer–Connectomics at GoogleIn this episode, Ken and Robert from part one return to the pub, and we are also joined by Jeremy Maitin-Shepard, an engineer and researcher at Google, who shares insights into some of the machine intelligence modalities being used to decode previously uncharted neural networks. Check out Jeremy’s recent paper on BioRxiv, as well as his published work at Google. If you missed part one, you can listen and explore the show notes here. Cheers!Show Notes: 0:00 | Intro1:03 | Kenneth Hayworth, PhD1:12 | Robert McKintyre, CEO, Nectome1:17 | Jeremy Maitin-Shepard, PhD1:51 | Setting the record straight 3:09 | The nucleotide sequence of bacteriophage φX1744:22 | Frozen Zoo at San Diego Zoo12:01| Glutaraldehyde and reduction techniques for immunolabeling 17:39 | SWITCH Framework19:14 | Population Responses in V1 Encode Different Figures by Response Amplitude Enhanced mirror neuron network activity and effective connectivity during live interaction among female subjects Permeabilization-free en bloc immunohistochemistry for correlative microscopy 19:57 | Synaptic Signaling in Learning and Memory Structure and function of a neocortical synapse Engineering a memory with LTD and LTP Synapse-specific representation of the identity of overlapping memory engrams 20:28 | Ultrastructure of Dendritic SpinesStructure–stability–function relationships of dendritic spines 24:25 | Reconstructing the connectome 24:32 | Connectomics Research Team at Google 24:55 | Google x HHMI: Releasing the Drosophila Hemibrain Connectome 28:38 | Serial Block-Face Scanning Electron Microscopy 29:22 | Automated Serial Sections to Tape29:45 | Mapping connections in mouse neocortex30:59 | A connectome and analysis of the adult Drosophila central brain 32:14 | Expansion Microscopy34:37 | The future of connectomics 45:13 | Contribution of apical and basal dendrites to orientation encoding in mouse V1 L2/3 pyramidal neurons49:49 | Mice and rats achieve similar levels of performance in an adaptive decision-making task Want More?Follow Neurotech Pub on TwitterFollow Paradromics on Twitter, LinkedIn, and InstagramFollow Matt on LinkedIn and Twitter
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    1 hr and 1 min
  • We're in Heated Agreement Over Here | Connectomics Part I

    We're in Heated Agreement Over Here | Connectomics Part I
    Mar 14 2023
    Welcome back to Neurotech Pub! In this first installment of two episodes on Connectomics, host and Paradromics CEO Matt Angle kicks off a lively discussion on the rapidly accelerating research in the mapping, preservation, and reconstruction of the human connectome. We explore the ethical and legal ramifications of disruptive technology, and some of the unique challenges faced when driving innovation in emerging industries. Our guests are:  Nita Faraheny, JD, PhD, Everett Distinguished Professor of Law & Philosophy at Duke Law School, the Founding Director of Duke Science & Society, the Faculty Chair of the Duke MA in Bioethics & Science Policy, and principal investigator of SLAP Lab.  Kenneth Hayworth, PhD, President and Co-Founder of the Brain Preservation Foundation, Senior Scientist at the Howard Hughes Medical Institute’s Janelia Farm Research Campus (JFRC) Robert McIntyre, CEO at NectomeAs an exciting new development since the recording of this episode, Nita recently published a book, The Battle for Your Brain, which examines many topics in neuroethics, from Connectomics to Brain-Computer Interfaces. It is currently available on Amazon.Keep an eye out for part two in this series, which will take a deep dive into the latest technical and engineering innovations in the connectomics ecosystem. Coming soon!Please be advised that this episode contains a brief discussion of assisted suicide in a medical setting.Show Notes: 0:00 | Episode Intro 1:16 | Nita A. Farahany, JD, PhD1:21 | Kenneth Hayworth, PhD1:27 | Robert McKintyre, CEO, Nectome1:56 | Meeting of the minds 2:53 | Aldehyde-stabilized cryopreservation wins final phase of brain preservation prize3:56 | The Brain Preservation Foundation4:09 | Documentary series on the Brain Preservation Foundation5:21 | Letter of Support for Aldehyde Stabilized Cryopreservation (and ‘next steps’ caveats)5:51 | Nita's 2018 Neuroethics Ted Talk 5:54 | International Neuroethics Society6:25 | Connectomics & new paths in neuroscience 8:10 | Allen Institute for Brain Science8:47 | A connectome and analysis of the adult Drosophila central brain9:33 | A visual intro to synaptic imaging in connectomics10:28 | The structure of the nervous system of the nematode Caenorhabditis elegans 11:16 | Mouse Connectome Project at CIC14:59 | Cryonics controversy 19:00 | Death, taxes, and synapses 20:51 | Uniform Law Commission21:08 | The Uniform Determination of Death Act24:25 | Watch Altered Carbon on Netflix25:49 | Understanding the “Loss of Chance” Doctrine 37:13 | Understanding Physician-Assisted Death, or ‘Death with Dignity’ 40:21 | Euthanasia in the Netherlands46:01 | Autonomy, Dignity, and Consent to Harm, Rutgers Law Review Want More?Follow Neurotech Pub on TwitterFollow Paradromics on Twitter, LinkedIn, and InstagramFollow Matt on LinkedIn and Twitter
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    49 mins
  • Neuro Mapping & Napping

    Neuro Mapping & Napping
    Aug 25 2022
    Welcome back to Neurotech Pub! In this episode we’re talking about sleep–why we sleep, how sleep works on a neurophysiological level, and some of the emerging sleep technologies that are about to revolutionize this essential neural activity.  Our guests are Amy Kruse, PhD, General Partner at Prime Movers Lab, Ram Gurumoorthy, PhD, Founder and CTO of Stimscience & Somnee, and Luis de Lecea, PhD, Professor of Psychiatry and Behavioral Sciences at Stanford University School of Medicine. This episode also features a video introduction to sleep stages by Paradromics Intern Zoe Lalji. This is essential viewing if you’re unfamiliar with the stages of sleep and want to follow along later in the episode. Cheers!Show Notes:  00:00 | Episode intro with Matt Angle and Amy Kruse1:07 | StimScience in Fast Company5:05 | Learned Motor Patterns Are Replayed in Human Motor Cortex during Sleep6:43 | Connect with Prime Movers Lab7:01 | PML on Medium7:45 | Introduction to Sleep StagesReferences: Stages of Sleep Overview REM vs Non-REM SleepSleep WalkingBenefits of REM SleepConsequences of low REM sleepImportance of Deep SleepCheck out Zoe’s nonprofit organization, ALS Heroes, and her Ted Talk12:24 | Pulling all-nighters12:50 | Amy Kruse, PhD13:00 | Ram Gurumoorthy, PhD13:07 | Stimscience, now Somnee13:30 | Luis de Lecea, PhD18:26 | Gordon Rule, PhD18:40 | Knights of the Old Republic II: The Sith Lords (2004)19:50 | Why do we sleep?20:26 | Sleep drives metabolite clearance from the adult brain20:35 | Sleep & DNA Repair22:13 | Neural Activity can cause DNA damage23:22 | Jerry Seigal24:26 | DARPA Sleep Research24:55 | Fur seals and sleep25:08 | How do Whales and Dolphins Sleep Without Drowning?25:54 | Putting Humans in Stasis Is the Best Way of Getting Us to Mars27:36 | Sleep and Mortality28:09 | The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices28:27 | Giulio Tononi, MD, PhD28:45 | Sleep, Memory, and Plasticity28:52 | Sleep Cognition and Memory29:00 | Sleeping up and down the phylogenetic tree29:05 | Actually...worms do sleep29:20 | Decoding sleep29:36 | Fruit flies and their mini sleeps29:44 | Mapping sleep in the brain30:35 | Hypocretin-positive neurons31:17 | Clearly Matt slept through his midterm... again31:57 | The hypocretins/orexins: integrators of multiple physiological functions32:05 | Stress-sleep interactions33:30 | The Science of Narcolepsy35:08 | Equivalence of sleep deprivation and intoxication | Additional reference36:21 | Sleep Pressure: Homeostatic Sleep Drive 40:38 | EEG Visualization of electrodermal activity during sleep44:08 | Circuitry of Sleep Stages45:00 | Regional slow waves and spindles in human sleep | Local sleep in awake rats48:00 | Emerging Sleep Technologies1:00:56 | Hypothalamus and SleepWant More?Follow Neurotech Pub on TwitterFollow Paradromics on Twitter, LinkedIn, and InstagramFollow Matt on LinkedIn and Twitter
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    1 hr and 6 mins
Science
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