• Neuro Mapping & Napping

  • Aug 25 2022
  • Length: 1 hr and 6 mins
  • Podcast

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Neuro Mapping & Napping

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  • Welcome back to Neurotech Pub! In this episode we’re talking about sleep–why we sleep, how sleep works on a neurophysiological level, and some of the emerging sleep technologies that are about to revolutionize this essential neural activity.  Our guests are Amy Kruse, PhD, General Partner at Prime Movers Lab, Ram Gurumoorthy, PhD, Founder and CTO of Stimscience & Somnee, and Luis de Lecea, PhD, Professor of Psychiatry and Behavioral Sciences at Stanford University School of Medicine. This episode also features a video introduction to sleep stages by Paradromics Intern Zoe Lalji. This is essential viewing if you’re unfamiliar with the stages of sleep and want to follow along later in the episode. Cheers!Show Notes:  00:00 | Episode intro with Matt Angle and Amy Kruse1:07 | StimScience in Fast Company5:05 | Learned Motor Patterns Are Replayed in Human Motor Cortex during Sleep6:43 | Connect with Prime Movers Lab7:01 | PML on Medium7:45 | Introduction to Sleep StagesReferences: Stages of Sleep Overview REM vs Non-REM SleepSleep WalkingBenefits of REM SleepConsequences of low REM sleepImportance of Deep SleepCheck out Zoe’s nonprofit organization, ALS Heroes, and her Ted Talk12:24 | Pulling all-nighters12:50 | Amy Kruse, PhD13:00 | Ram Gurumoorthy, PhD13:07 | Stimscience, now Somnee13:30 | Luis de Lecea, PhD18:26 | Gordon Rule, PhD18:40 | Knights of the Old Republic II: The Sith Lords (2004)19:50 | Why do we sleep?20:26 | Sleep drives metabolite clearance from the adult brain20:35 | Sleep & DNA Repair22:13 | Neural Activity can cause DNA damage23:22 | Jerry Seigal24:26 | DARPA Sleep Research24:55 | Fur seals and sleep25:08 | How do Whales and Dolphins Sleep Without Drowning?25:54 | Putting Humans in Stasis Is the Best Way of Getting Us to Mars27:36 | Sleep and Mortality28:09 | The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices28:27 | Giulio Tononi, MD, PhD28:45 | Sleep, Memory, and Plasticity28:52 | Sleep Cognition and Memory29:00 | Sleeping up and down the phylogenetic tree29:05 | Actually...worms do sleep29:20 | Decoding sleep29:36 | Fruit flies and their mini sleeps29:44 | Mapping sleep in the brain30:35 | Hypocretin-positive neurons31:17 | Clearly Matt slept through his midterm... again31:57 | The hypocretins/orexins: integrators of multiple physiological functions32:05 | Stress-sleep interactions33:30 | The Science of Narcolepsy35:08 | Equivalence of sleep deprivation and intoxication | Additional reference36:21 | Sleep Pressure: Homeostatic Sleep Drive 40:38 | EEG Visualization of electrodermal activity during sleep44:08 | Circuitry of Sleep Stages45:00 | Regional slow waves and spindles in human sleep | Local sleep in awake rats48:00 | Emerging Sleep Technologies1:00:56 | Hypothalamus and SleepWant More?Follow Neurotech Pub on TwitterFollow Paradromics on Twitter, LinkedIn, and InstagramFollow Matt on LinkedIn and Twitter
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