Dan O'Neill, MVB, PhD, FRCVS is a veterinary epidemiologist who studies canine disorders that have an inherited component - what the rest of us might call "genetic diseases." He is the author of more than 95 papers, mostly on the prevalence and risk factors of disorders in dogs based on data drawn from VetCompass, the large scale veterinary database and research tool that he co-leads. Dan was awarded the Kennel Club Charitable Trust "International Canine Health Award" in 2021, and is passionate both about the health of purebred dogs and about saving breeds.

Danika Bannasch, DVM, PhD returns to the podcast to talk about the Dalmatian Outcross Project. Danika's laboratory found the genetic mutation that was targeted in this outcross, and she had a front row seat to the project's path to acceptance by the AKC and the Dalmatian Club of America. She is also herself a past breeder of Dalmatians. Danika walks us through the genetic, social, and practical implications of high uric acid in Dalmatians, why the outcross was necessary, how it worked, and which populations with different mutations could be helped today by a similar approach (spoiler - one of them is the population of dogs in breeds with high frequency of the chondrodystrophy mutation that we discussed in the previous episode).

Danika Bannasch, DVM, PhD is the owner of Pint, the famous UC Davis football tee retrieving dog. She also happens to run a genetics lab, also at UC Davis, where she studies the genetics of inherited diseases in dogs and other animals. She is known for her work associating genetic variants with a variety of traits including coat color and skull shape. On this episode we're talking about a genetic mutation that she discovered - known to genetic testing companies as CDDY - for a trait she feels passionately about, chondrodystrophy. Most of the dog world knows this mutation as "that risk gene that makes your dog more likely to get IVDD," but in this episode, Danika talks us through the difference between disc herniation and IVDD (intervertebral disc disease), noting that all dogs with CDDY have IVDD, and therefore disc degeneration, whether or not they actually herniate. I hope you learn as much from this discussion as I did.

Find this episode's transcript here.