Although molecular testing offers promising opportunities for diagnosis and targeted treatment of cancers, prostate cancer has lagged behind other types of cancer. Recently, homologous recombination repair testing in prostate cancer has provided a means to achieving targeted treatments for patients as well as opening new avenues of collaboration between pathologists and oncologists.

On this episode of Inside the Lab, hosts Ms. Kelly Swails, MLS(ASCP), and Dr. Ali Brown, MD, FASCP are joined by Heather Cheng, a medical oncologist and associate professor of hematology and oncology at the University of Washington and Fred Hutchinson Cancer Center, and Colin Pritchard, molecular pathologist and professor of laboratory science and director of the Genetics and Solid Tumors Laboratory at the University of Washington Medical Center.

Our panelists discuss the current treatment landscape for prostate cancer and how HRR testing can improve patient outcomes in this context.

Topics Covered

• An introduction to metastatic prostate cancer testing, and what types of tests are standard of care, and the rationale for targeting prostate cancer using PARP
• Key findings from recent phase III randomized clinical trials
• Standards for optimal testing in prostate cancer, particularly concerning sample sources and the choice between next-generation sequencing (NGS) and polymerase chain reaction (PCR) methods
• common pitfalls or challenges in the arena of accurately reporting and interpreting findings from HRR tests
• Practical tips for optimal coordination among a multidisciplinary, cross-departmental team of healthcare providers and laboratory professionals when utilizing HRR testing in prostate cancer management.

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Dr. Cheng on LinkedIn

Connect with Dr. Pritchard
Dr. Pritchard

Connect with Ms. Swails & Dr. Brown
Ms. Swails on Twitter
Dr. Brown on Twitter

Resources
ASCP Membership 2024
Proposed FDA Regulation of Laboratory Developed Tests
Public Comment on the FDA’s Proposed Rule
Inside the Lab in the ASCP Store

As CRC affects younger and more diverse populations, emerging tests for CRC biomarkers provide enormous utility for diagnosis. However, misdiagnosis of CRC, shifting demographics of those afflicted with CRC, and patient unfamiliarity with symptoms create challenges in identifying CRC. In this episode of Inside the Lab, hosts Dr. Ali Brown and Lotte Mulder are joined by Dr. Melissa Taggart, a board-certified pathologist at MD Cancer Center and Karla Valencia, a laboratory manager at MD Anderson Cancer Center to discuss the utility of biomarker testing for CRC.

The hosts are also joined by Sarah Claeys, who was diagnosed with Stage I CRC in 2020 and is now actively fighting Stage IV recurrence with metastatic disease primarily in the liver, and ASCP Patient Champion Heather Tucker, who suffered from misdiagnosis for years before being diagnosed for CRC. She completed treatment 5 years ago. Sarah and Heather share their experiences with seeking both diagnosis and treatment, and provide insights on what information related to biomarkers were most valuable to them.

Topics Covered in this podcast include:

• How have tests for CRC evolved recently, and which biomarkers they test for;
• How laboratory quality control is used to ensure the accuracy and reliability of colorectal cancer biomarker test results;
• Factors involved with validating and implementing new biomarker assays for CRC in the laboratory;
• Handling pre-analytical variables and potential interferences that may affect the interpretation of biomarker test results for colorectal cancer;
• How pathologists integrate molecular and biomarker findings into pathology reports;
• What information related biomarkers was most valuable from a patients’ perspective was most valuable when seeking treatment for CRC, as well as patient advice for healthcare professionals, including pathologists and laboratory professionals, regarding laboratory testing, including biomarker testing.

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ASCP

ASCP on Facebook

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Connect with Ms. Bartosh, Ms. Courtright & Mr. Bowman

University Health Laboratory Services

Ms. Bartosh on LinkedIn

Connect with Ms. Swails & Dr. Brown

Ms. Swails on Twitter

Dr. Mulder on Twitter

Resources

CAP Inspection Checklists

ASCP Patient Champions Program

Inside the Lab in the ASCP Store

Recent developments in disease modifying therapies have been proven to slow the progression of cognitive decline associated with Alzheimer’s disease. 

And yet, we can only confirm a diagnosis of AD after a patient’s death. 

But what if we could use biomarkers to identify preclinical stage Alzheimer’s and step in long before a patient exhibits dementia? 

On this episode of Inside the Lab, your host, Ms. Kelly Swails, MT(ASCP) introduces us to Dr. Shih-Hsiu Jerry Wang, MD, PhD, Assistant Professor of Pathology and Assistant Professor of Neurology at the Duke University School of Medicine, and shares his talk on emerging biomarkers for the assessment of Alzheimer’s disease from the ASCP 2023 Annual Meeting. 

Dr. Wang explains how we measure AD right now and why there’s discordance between the clinical presentation and pathology of Alzheimer’s. 

Dr. Wang walks us through the core biomarkers for identifying AD per the AT(N) framework, describing the pros and cons of current detection methodologies and offering recommendations around when to use blood biomarkers versus PET imaging or CSF. 

Listen in for insight into the ongoing search for better AD biomarkers and learn what we are doing to diagnose Alzheimer’s in its early stages and intervene accordingly. 

Topics Covered  

· The clinical definition of Alzheimer’s disease and how it impacts cognitive function
· How we measure Alzheimer’s in pathology by amyloid plaques and neurofibrillary tangles
· Why there’s discordance between the clinical presentation and pathology of AD
· The core biomarkers for identifying Alzheimer’s disease per the AT(N) framework
· Identifying the stages of AD based on amyloid plaque, pathologic tau and neurodegeneration
· Examples of PET imaging for the different stages of AD and how imaging biomarkers predict cognitive decline
· The limitations of fluid biomarkers vs. imaging biomarkers to detect Alzheimer's disease
· Some of the emerging ultrasensitive biomarker detection methods in development for AD
· Using cerebral spinal fluids (CSF) vs. plasma biomarkers to identify Alzheimer's disease
· A comparison of the mass spectrometry vs. SIMOA methods of analyzing p-tau biomarkers
· Why Dr. Wang suggests blood biomarkers for AD screening (with confirmation by PET or CSF)
· Why SNAP-25, NfL and GFAP are not considered core biomarkers for Alzheimer’s disease
· The ongoing search for better biomarkers and ultrasensitive detection methods for AD 

Connect with ASCP
ASCP
ASCP on Facebook
ASCP on Instagram
ASCP on Twitter 

Connect with Dr. Wang
Dr. Wang at Duke University 

Connect with Ms. Swails
Ms. Swails on Twitter

Resources
Dr. Wang’s Slides from the ASCP Annual Meeting 2023
‘NIA-AA Research Framework: Toward a Biological Definition of Alzheimer’s Disease’ in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association
Inside the Lab in the ASCP Store