En este episodio hablaremos sobre uno de los estudios más interesantes llevados a cabo durante los últimos años, THE NUN STUDY. Un estudio que trata de aportar conocimiento acerca de las causas que producen la enfermedad de Alzheimer en un grupo de 678 monjas.

Listado de referencias utilizadas:

• https://elpais.com/salud-y-bienestar/2023-02-23/un-joven-chino-de-19-anos-es-la-persona-mas-joven-con-alzheimer-y-la-causa-es-un-misterio.html
• Jia J, Zhang Y, Shi Y, Yin X, Wang S, Li Y, Zhao T, Liu W, Zhou A, Jia L. A 19-Year-Old Adolescent with Probable Alzheimer's Disease. J Alzheimers Dis. 2023;91(3):915-922.
• Age-specific death rates for leading cause of death in the older population, United States, 2010. Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System. 2014 annual mortality file.
• World Alzheimer Report 2015 The Global Impact of Dementia An analysis of prevalence, incidence, cost and trends. https://www.alz.co.uk/research/WorldAlzheimerReport2015.pdf
• Winblad B, Amouyel P, Andrieu S, Ballard C, Brayne C, Brodaty H, Cedazo-Minguez A, Dubois B, Edvardsson D, Feldman H, Fratiglioni L. Defeating Alzheimer's disease and other dementias: a priority for European science and society. The Lancet Neurology. 2016 Apr 1;15(5):455-532.
• H Braak, E Braak: Neuropathological stageing of Alzheimer disease related changes. Acta Neuropathol (Berl). 82:239-259 1991.
• Forsyth E, Ritzline PD. An overview of the etiology, diagnosis, and treatment of Alzheimer disease. Physical therapy. 1998 Dec 1;78(12):1325-31.
• Snowdon DA. Aging and Alzheimer's disease: lessons from the Nun Study. Gerontologist. 1997 Apr;37(2):150-6. doi: 10.1093/geront/37.2.150. PMID: 9127971.
• Snowdon DA, Kemper SJ, Mortimer JA, Greiner LH, Wekstein DR, Markesbery WR. Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the Nun Study. JAMA. 1996 Feb 21;275(7):528-32. PMID: 8606473.

En este episodio responderemos a la pregunta “¿cuántos pasos deberían de caminar cada día?”. Además, también discutiremos que pasa si no se alcanzan las recomendaciones que nos da la literatura científica y como monitorizar el esfuerzo que estás haciendo mientras caminas.

Listado de referencias utilizadas:

• SparlingPhillip B, Howard Bethany J, DunstanDavid W, Owen Neville. Recommendations for physical activityin older adultsBMJ 2015; 350:h100
• PiercyKL, TroianoRP, Ballard RM, et al. The Physical Activity Guidelines for Americans. JAMA. 2018;320(19):2020–2028.
• Garatachea N, Pareja-Galeano H, Sanchis-Gomar F, Santos-Lozano A, Fiuza-Luces C, Morán M, et al. Exercise attenuates the major hallmarks of aging. Rejuvenation research, 2015. 18(1), 57-89.
• Warburton DE, Nicol CW, Bredin SS. Health benefits of physical activity: the evidence. Cmaj. 2006 Mar 14;174(6):801-9.
• Nelson ME, RejeskiWJ, Blair SN, Duncan PW, JudgeJO, King AC, et al. Physical activityand public healthin older adults: recommendation from theAmerican College of SportsMedicine and theAmerican Heart Association. Med Sci Sports Exerc2007 Aug;39(8):1435-1445.
• American College of Sports Medicine, Chodzko-Zajko WJ, Proctor DN, FiataroneSingh MA, Minson CT, Nigg CR, et al. American College of Sports Medicine position stand. Exercise and physical activity for older adults. Med Sci Sports Exerc 2009 Jul;41(7):1510-1530.
• QuickStats: Percentage of Adults Aged ≥65 Years Meeting 2008 Federal Guidelines for Leisure-Time Aerobic and Muscle-Strengthening Activities, by Age and Type of Activity — United States, 2000–2002 and 2013–2015. MMWR MorbMortal Wkly Rep 2016;65:1019.
• Bennie JA, De Cocker K, Teychenne MJ, Brown WJ, Biddle SJH. The epidemiology ofaerobic physical activity and muscle-strengthening activity guideline adherence among383,928 U.S. adults. Int J Behav Nutr Phys Act. 2019 Apr18;16(1):34.
• Lee IM, ShiromaEJ, KamadaM, BassettDR, Matthews CE, BuringJE. Association ofStep Volumeand Intensity With All-Cause Mortalityin Older Women. JAMA Intern Med. 2019 Aug1;179(8):1105-1112.
• Paluch AE, Gabriel KP, Fulton JE, et al. Steps per Day and All-Cause Mortality in Middle-aged Adults in the Coronary Artery Risk Development in Young Adults Study. JAMA Netw Open. 2021;4(9):e2124516.
• Reed, J. L., & Pipe, A. L. (2014). The talk test: a useful tool for prescribing and monitoring exercise intensity. Current opinion in cardiology, 29(5), 475-480.
• Ekelund U, Tarp J, Steene-Johannessen J, Hansen BH, Jefferis B, Fagerland MW, Whincup P, Diaz KM, Hooker SP, ChernofskyA, Larson MG, Spartano N, Vasan RS, Dohrn IM, Hagströmer M, Edwardson C, Yates T, Shiroma E, AnderssenSA, Lee IM. Dose-response associations between accelerometry measured physical activity and sedentary time and all cause mortality: systematic review and harmonisedmeta-analysis. BMJ. 2019 Aug 21;366:l4570.
• Grandes G, García-Alvarez A, Ansorena M, Sánchez-Pinilla RO, Torcal J, Arietaleanizbeaskoa MS, Sánchez A; PEPAF group. Any increment in physical activity reduces mortality risk of physically inactive patients: prospective cohort study in primary care. Br J Gen Pract. 2022 Dec 21;73(726):e52-e58.

Listado referencias. #1. Sarcopenia:

1. Cruz-Jentoft AJ, et al.; European Working Group on Sarcopenia in Older People. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010 Jul;39(4):412-23.

2. Cruz-Jentoft AJ, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019 Jan 1;48(1):16-31.

3. Malmstrom TK et al. SARC-F: a simple questionnaire to rapidly diagnose sarcopenia. JAMDA J Am Med Dir Assoc. 2013;14(8):531-532

4. Ishii S, Tanaka T, Shibasaki K, Ouchi Y, Kikutani T, Higashiguchi T, Obuchi SP, Ishikawa-Takata K, Hirano H, Kawai H, Tsuji T, Iijima K. Development of a simple screening test for sarcopenia in older adults. Geriatr Gerontol Int. 2014 Feb;14 Suppl 1:93-101.

5. Guralnik JM, Simonsick EM, Ferrucci L, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 1994 03;49(2):M85 M94.

6. Mathiowetz V, Weber K, Volland G, et al. Reliability and validity of grip and pinch strength evaluations. J Hand Surg Am 1984 03;9(2):222-226.

7. Sun YS, Kao TW, Chang YW, Fang WH, Wang CC, Wu LW, Yang HF, Liaw FY, Chen WL. Calf Circumference as a Novel Tool for Risk of Disability of the Elderly Population. Sci Rep. 2017 Nov 27;7(1):16359.

8. Verlaan S, Aspray TJ, Bauer JM, Cederholm T, Hemsworth J, Hill TR, McPhee JS, Piasecki M, Seal C, Sieber CC, Ter Borg S, Wijers SL, Brandt K. Nutritional status, body composition, and quality of life in community-dwelling sarcopenic and non-sarcopenic older adults: A case-control study. Clin Nutr. 2017 Feb;36(1):267-274.